1. N.KARANADZE, T.JIKUTASHVILI, E.KHOMERIKI, T.IMERLISHVILI
CONSERVATION OF THE AMNION IN HONEY
J. Experimental and Clinical Medicine, 2005, 1, pp.8-12.
Chair of Ophthalmology, Tbilisi State Medical University, Georgia
Treatment of visual impairment caused by the diseases of the ocular fundus is still an actual problem of ophthalmology. Nowadays, different methods of treatment are used: laser photocoagulation, photodynamic therapy, transpupillary thermotherapy and radiation treatment, vitamins, different biostimulators, sub-Tenon and suprachoroidal implantation of various synthetic and biological preparations etc.
We propose a new method of treatment: implantation of meliterized amniotic membrane into the sub-Tenon capsule.
The aim of our investigation was to study the morphologic structure of the amniotic membrane stored in 100 % bee honey during different periods of conservation (3, 5 and 7 months).
Proceeding from the results, we can state that honey is an ideal, safe product for the conservation of the amniotic membrane, and that meliterized amniotic membrane maintains its main histomorphologic features, and it can be used for transplantation.
ESTIMATION OF THE RESULTES OF MELLITERED SKIN TRANSPLANTATION
J. Experimental and Clinical Medicine, 2005, 1, pp.12-15.
A.Natishvili Institute of Experimental Morphlogy Georgian AS, Tbilisi, Georgia
We morphologically investigated the results of transplantation of rat skin grafts preserved at 4°C in natural honey per 3,7,14,30 days. Graft attraction from host tissues before the 14th day after transplantation was considered to be a false healing, after this time – to be the true one. 3-7 day-old grafts uptake rate is normal. The uptake of skin grafts preserved per 14 days was false in 25%.On the 30th day of preservation healing didn’t occur.
Based on these results, we can conclude that skin grafts preserved in natural honey may be used for transplantation before the 14-17th days of conservation. After this time, grafts can be used as a temporary biological cover, because they can stimulate normal reepithelization in skin defects.
3. M.CHKHIKVISHVILI, R.KAPANADZE
THE CONSTRUCTION OF LINGUAL LYMPH VESSELS AND ITS AGE-RELATED CHANGES
J. Experimental and Clinical Medicine, 2005, 1, pp.15-17.
Georgian State Medical Academy, Pathology Department of the Institute of Cardiology, Tbilisi
Basing on the comparison of microanatomical and micrometrical researches, it’s possible to conclude that with aging the lymphatic capillary network of the tongue becomes looser and the diameter of the capillaries of all sizes is reduced (narrowed). That narrowing starts from the age of 60, and network loosening – from the beginning of senility.
For the microtopography of the lymphoid formations of the esophagus
J. Experimental and Clinical Medicine, 2005, 1, pp.17-21.
The Department of Human Anatomy, Azerbaijan Medical University, Baku
There was studied the microscopic anatomy and topography of the lymphoid structures of the esophagus from 96 corpses of individuals of both sexes and various ages.
It is ascertained that definite microtopographic associations of lymphocytes with macrophages and plasmocytes are present in the all-lymphoid formations of the esophagus.
OSMOLALITY OF BIOLOGICAL LIQUIDS – BLOOD SERUM AND URINE - DURING PREGNANCY COMPLICATED BY EDEMA AND PRE-ECLAMPSIA
J. Experimental and Clinical Medicine, 2005, 1, pp.21-24.
Tbilisi State Medical University, Chair of Midwifery–Gynecology ¹2, Chair of Internal Medicine ¹5, Georgia
The aim of our research was measuring of osmolality of biological liquids – blood serum and urine - during edema of pregnancy and pregnancy complicated by pre-eclampsia in the II and III terms of pregnancy by a fundamentally new conductance-measuring method of osmolality; study of the interdependency of developed changes, interpretation of received data. The research was carried out with 93 women at the age of 16 to 38. According to our results, in the II and III groups similar changes took place in the osmolality of biological liquids – blood serum and urine.
6.N.BAKRADZE, S.PETROSYAN, M.GELASHVILI, KH.DIDEBELI, L.TODUA, M.OKRUASHVILI, E.KITIASHVILI
ELUTING STENTS WITH ANTIRESTENOSIS COVERS – A NEW DIRECTION IN INTERVENTIONAL CARDIOLOGY
J. Experimental and Clinical Medicine, 2005, 1, pp.24-27.
Medical Institute “Tbilisi”, Georgia; San-ko Medical Centre, Gaziantep, Turkey
Struggle against the development of the neo-intima is one of the most actual problems for interventional cardiology. Eluting Stents with anti-neointima curative covers having antiproliferative effects on the intima are very important for avoiding the occurrence of restenosis. Preparations of three different groups - Paclitaxe (Taxol), Rapamicin (Sirolymus) and Everolymus - used as stent covers actually reduce the risk of the development of the neo-intima inside the stent and the occurrence of restenosis.
The obtained results indicate that in future, after the doses of covering preparations, the density of the cover and the speed of their separation becomes more precise, and the outcome will certainly be better.
7. VELIEVA G.D.
ELECTRICAL ACTIVITY OF THE BRAIN AND CORRELATION OF SOME VEGETATIVE PARAMETERS UNDER DIFFERENT FUNCTIONAL CONDITIONS OF THE BRAIN IN CHILDREN AGED 7-14 YEARS
J. Experimental and Clinical Medicine, 2005, 1, pp.27-29.
Chair of Normal Physiology of Azerbaijan Medical University, Baku
The current work is regarding the study of the parameters (EEG, EKG, pletizmogram, pneumogram, KGR – skin galvanic reaction) of 48 healthy people aged 7 to14 in a normal condition (relaxed vigil) and under modeled tension (mental activity) - positive and negative emotional conditions. There were analyzed the indices of beta-, alfa-, and teta- rhythms of brain electrical activity. The correlation analyses of the researched vegetative parameters also were carried out.
8. N.T.LORTKIPANIDZE, T.M.LORTKIPANIDZE
COMBINATION OF ALOPECIA AREATA AND OTHER AUTOIMMUNE DISEASES
J. Experimental and Clinical Medicine, 2005, 1, pp.29-32.
Scientific-Research Institute of Dermatology and Venereology, Chair of Internal Diseases, Medical Faculty of Iv. Javakhishvili Tbilisi State University, Georgia
The aim of the study was to ascertain the reliability of the combination of alopecia and other autoimmune diseases (systemic lupus erythematosus, systemic scleroderma, myasthenia gravis, psoriasis, autoimmune thrombocytopenic purpura). These diseases were diagnosed in leading medical centers of Georgia. Selection of patients was held via the method of simple random sampling (randomization): reliability was being defined by the x²_test. In 200 persons of the control group (ambulatory reception of a surgical profile) alopecia areata was found in one; out of 200 diseased by myasthenia - in 4; out of the diseased by lupus erythematosus and systemic scleroderma (200 patients) correspondingly – in 3 and 2; among the diseased by psoriasis – one person, and among 100 diseased by autoimmune thrombocytopenic purpura – also one. Therefore, during the studied autoimmune diseases alopecia areata is found more frequently than in the control group, but the x²_test didn’t confirm the presence of a reliable difference in any of these cases.
9. M.DVALI, E.MSHVIDOBADZE, N.TSINTSADZE, B.SIRBILADZE, S.MIRTSKHULAVA
LASER TREATMENT OF STRABISMUS AND REFRACTIVE AMBLIOPIA IN ADOLESCENTS
J. Experimental and Clinical Medicine, 2005, 1, pp.32-35.
Our experience shows that hyperopic Lasik can be successfully used not only for the correction of visual acuity, but also as a treatment for ambliopia and strabismus.
10. T.KILASONIA, I.KUZANOV, S.KUTUBIDZE
VASCULARIZED FLAP PREFABRICATION AND BIOCOMPATIBLE MATERIALS IN TISSUE BIOENGINEERING
J. Experimental and Clinical Medicine, 2005, 1, pp.35-38.
Georgian Medical Academy, Chair of Aesthetic and Plastic-Reconstructive Surgery, Tbilisi
Visualization increase using the method of prefabrication is a new way in vascularized flap surgery.
Purposes of the research: 1) creation of a vascularized flap; 2) ascertain of possibilities, effectiveness, indications, contraindications and expediency of prefabrication methods; 3) usage of biocompatible materials for prefabrication.
The term “prefabrication”, in its broad sense, implies reshaping, remodeling or artificial creating a vascularized flap. Silicone and carbon materials are mostly used as biocompatible materials. If vascular growth occurs in the artificial implant, compound flaps are created, which subsequently are used for the reconstruction of cutaneous and osteocutaneous defects.
Experiments have been made on white laboratory rats. We have some experimental models where we create arteriovenous vascularized flaps. During vascularized flap prefabrication, we made caudal artery and vain transposition by 180o, subcutaneously in rat back area. We made the cutaneous and osteocutaneous flap models. For results we used micro-angiographic, morphological and immunohistochemical analyses.
Obtained morphological results: an increase in neoangiogenesis and vascularization in parallel to prefabrication.
The use of this method assumes the possibility of an increase in vascularization of flaps, creation of new donor zones for vascularized flaps, and therefore, an improvement in the results of reconstructive-plastic operation.
CLINICAL-EXPERIMENTAL STUDY OF CROSS-MODAL NEUROPLASTICITY
J. Experimental and Clinical Medicine, 2005, 1, pp.38-40.
Department of Ophthalmology, Tbilisi State Medical University, Georgia
The latest data testify a sufficient amount of information (mostly electrophysiological) concerning neuroplastic properties of the brain, but we don’t know much about biological meaning of this phenomenon, and practically nothing – about the mechanisms of its development. Here is given brief information concerning clinical and experimental evidences of cross-modal neuroplasticity during early blindness.
DENSITY OF THE LYMPHOID TISSUE IN DIFFERENT SECTIONS OF THE FEMALE URETHRA DURING ONTOGENESIS
J. Experimental and Clinical Medicine, 2005, 1, pp.40-44.
Department of Human Anatomy, Azerbaijan Medical University, Baku
The density of the lymphoid tissue of the female urethra was studied in various age groups by the macro-microscopic method.
The analysis showed available tendency of the lymphoid nodes distribution density in the main age groups to increase in the proximal direction.
13.D.SHENGELIA, N.KARANADZE, M.CHIKOVANI, T.GABASHVILI, EL.BALIASHVILI, M.CHAVCHANIDZE
TREATMENT OF GLAUCOMATOUSE ATROPHY OF THE OPTIC NERVE
J. Experimental and Clinical Medicine, 2005, 1, pp.44-47.
Chair of Ophthalmology, Tbilisi State Medical University, Georgia
Purpose: The research aimed to study the antioxidant and biostimulating effects of Meliterized brephosclera and amnion enriched with antioxidant extract in the treatment of complicated glaucomatous optic nerve atrophy.
Methods: The procedures were performed by sub-Tenon implantation of Meliterized Brephosclera and amnion. The period of the observation was not less than six months.
Results: All patients were pleased with their visual acuity. It was showed that a long-term exposition of Meliterized brephosclera and amnion provides antioxidant effect and increase of local blood circulation.
Conclusions: Owing to this method, prognosis of glaucoma isn’t so pessimistic. The observation is continued in hope of blindness prevention.
See further results in next editions.
14. N.T.MOVSUMOV, I.A.GIYASBEYLI
morphological characterization of the lymphoid apparatus of the female urethra during postnatal ontogenesis
J. Experimental and Clinical Medicine, 2005, 1, pp.47-50.
Chair of Human anatomy, Azerbaijan Medical University, Baku
We showed the characterization of some morphological features of the lymphoid apparatus of this organ during ontogenesis as we were studying total preparations of the female urethra taken from corpses of women of various ages. We determined that all-lymphoid formations of the female urethra during postnatal ontogenesis are concentrated around the excretory ducts and the initial sections of the urethral glands.
15. N.KARANADZE, M.CHIKOVANI, K.TKEBUCHAVA, E.CHOPIKASHVILI
THE USAGE OF THE PREPARATION TRAUMEEL S IN THE PERIOD FOLLOWING THE CATARACT OPERATION
J. Experimental and Clinical Medicine, 2005, 1, pp. 50-54.
Chair of Ophthalmology, Tbilisi State Medical University
The anti-homotoxic preparation Traumeel S is an effective and economical medicine, which shortens the period of rehabilitation of a patient after cataract extraction and avoids difficulties accompanying long-term use of steroid and non-steroid anti-inflammatory preparations.
16. V.B.SHADLINSKY, N.H.ALIEVA
AGE PECULIARITIES OFDISTRIBUTION DENSITY OF LYMPHOID NODES IN THE WALLS OF THE HUMAN ESOPHAGUS
J. Experimental and Clinical Medicine, 2005, 1, pp. 54-57.
Chair of Human Anatomy, Azerbaijan Medical University, Baku
Lymphoid nodes were studied in total preparations of the human esophagus (117 corpses of individuals of various ages). The density of distribution of lymphoid nodes implies the quantity of these anatomic formations corresponding to the area of 1sm2 of the esophagus wall.
It is ascertained that distribution density of the lymphoid nodes significantly changes during postnatal ontogenesis.
17. M.CHKIKVISHVILI, L.CHELIDZE
SOME DATA REGARDING ODONTOGENIC INFLAMMATORY PROCESSES OF THE TONGUE
J. Experimental and Clinical Medicine, 2005, 1, pp. 57-60.
Tbilisi State Medical Academy, Georgia
The frequency of odontogenic inflammation of the tongue increases in the patients aged 45-59 and progresses with aging, that must be connected with age related changes in the organism, and particularly in the tongue and its adjacent tissues.
MORPHOMETRICAL INVESTIGATION OF SKIN BURN WOUND HEALING WITH “PHAGOBIODERM” IN THE EXPERIMENT
J. Experimental and Clinical Medicine, 2005, 1, pp. 60-63.
A.Natishvili Institute of Experimental Morphology, Georgian AS, Tbilisi, Georgia
The role of artificial skin substitutes in treatment of burn wound is constantly evolving. The purposes of this study are, first, to examine “Phagobioderm” effects on the healing of skin burns, and second, to compare that with other artificial skin substitutes (polymer with silver sulphadiazine). Materials were examinated in three groups by morphometry to estimate the level of angiogenesis and mast cells at various periods. The results of this study have shown the advantage of “Phagobioderm” in comparison to other specimens (in our case - silver sulphadiazine).
19. R. MIKELADZE, S. KOUPRADZE, N. KORSANTIA
THE ACTION OF PHENOWINE AND PLAFERON-LB ON RAUSCHER VIRUS REPRODUCTION AND IMMUNE INDICES IN WHITE MICE
J. Experimental and Clinical Medicine, 2005, 1, pp. 63-65.
Institute of Medical Biotechnology of the Georgian Academy of Sciences, Tbilisi, Georgia
Experimental viral Rauscher leukemia in BALB/c mice is very convenient model for study of cure and prophylactic properties of plaferon and phenowine (preparations possessing imuno-modulating, antioxydant and apoptos-enhancing effects). Plaferontherapy was followed by twofold increase of time of survival of animals (death in control group – on 21-th day of infection). However, the next development of leukemia occured in the same way as in control and in 68% ended with death of mice. Hence, the inhibition of leukosigenic process in early stages of infection does not mean fool neutralization of virus reproduction. A comparative immunological analysis allows us to suppose that exactly the activation of the immune factors is basic in the mechanism of the protective action of plaferon and phenowine.