1. KAVTIASHVILI K., MACHAVARIANI T., GVAMICHAVA T., GACHECHILADZE I.
VASCULAR-TISSUE RELATION AND COMPENSATORY-REGENERATIVE PROCESSES IN THE LIVER AGAINST THE BACKGROUND OF BIOLOGICAL STIMULATION
J. Experimental and Clinical Medicine, 2006, 6, pp.9-12.
A.N.Natishvili Institute of Experimental Morphology, Tbilisi, Georgia
The efficiency of the newborn allogenic hepatocytes (NAH), liver homogenate and extract in the treatment of acute liver failure (ALF) in rats has been studied histologically, histochemically and ultrastructurally by the autoradiographic method.
The administration of NAH liver homogenate and extract prevents in part the ischemic cell death and is efficient for the stimulation of the liver regeneration in ALF; it increases metabolic and proliferative activity of hepatocytes as well as of reticulo-endothelial cells, facilitates the morpho-functional restoration of the recipient damaged liver.
MODERN ASPECTS OF SURGICAL TREATMENT FOR ESOPHAGEAL CANCER
J. Experimental and Clinical Medicine, 2006, 6, pp.12-15.
Department of General Surgery, Azerbaijan Medical University, Baku
The study reflects the results of surgical treatment in patients with esophageal cancer who survived avter the Lewis type procedure acomplished by two-or three field limphodissection.
PREDICTORS OF SEVERE MATERNAL MORBIDITY: CASE-CONTROL STUDY
J. Experimental and Clinical Medicine, 2006, 6, pp.15-18.
Department of Obstetrics and Gynecology ¹2, Institute of Postgraduate Education and Continuous Professional Development, Tbilisi State Medical University
Objectives: To reveal the predictors of severe maternal morbidity in Tbilisi by developed criteria. Material and methods: Case-control study of severe maternal morbidity in all maternity units of Tbilisi and D.Bochorishvili National Antisepsis Centre delivering 18 852 women from January 1, 2004 to January 1, 2005. The main group consisted of 267 patients, control – 1068. Results: The results showed that significant predictors of severe maternal morbidity are: past (OR 21.54) and current hypertension (OR - 7.60), lupus erythomatosus (OR - 20.36), admission to hospital during pregnancy (OR - 10.04), feto-placental failure (OR - 7.13), renal diseases (OR - 6.36), delivery by emergency caesarian section (OR - 3.14), stillbirth in the past (OR - 2.62), myoma uteri (OR - 2.54), anemia (OR - 2.35), fetal hypotrophy (OR - 2.33), obesity (OR - 2.29), spontaneous abortion (OR - 2.10), patient age over 35 years (OR - 1.86), abnormalities of palcenta (OR - 1.96), caesarean section in the past (OR - 1.79). Conclusions: The application of predictors obtained by our investigation will be useful to reveal a group of patients requiring additional attention. There is planned the development of evidence - based guidelines for cases of severe maternal morbidity throughout Georgia.
4. AKHUNBAYLI A., KERIMOV A., RACHIMOV V., ISMAILOV I., MIRZOEVA V.
DYNAMICS OF TROMBOCYTES CONTENT AND THEIR AGGREGATION IN BLOOD OF PATIENTS WITH SEVERE CRANIOCEREBRAL INJURY DURING “SHOCK” LUNG DISEASE
J. Experimental and Clinical Medicine, 2006, 6, pp.18-22.
Department of Internal Diseases and Reanimatology of AMU;
Department of Reanimatology and Itensive Therapy of Clinical Medical Centre, Baku, Azerbaijan
In order to diagnose the content of thrombocytes and their aggregation in the blood of patients with severe craniocerebral injury and developed “shock” lung, there were studied thrombocytes and their capacity for aggregation. The researches have shown that in the lung capillaries of the patients with severe craniocerebral injury there is a quantitative reduction of thrombocytes and the intensification of their aggregation. Depending on the stage, these changes are of a progressive character. Thus, thrombocytes can be one of the factors eliciting “shock” lung, and changes in their quantity and aggregation can have a prognostic character.
5. PANCULAIA I., TUKHASHVILI K., ABZIANIDZE E., ORJONIKIDZE C., KALANDARISHVILI F.
GENETICAL ABILITY TO TRANSMIT ANXIETY CONDITION FROM RATS WITH CHRONICA PSYCHOGENIC STRESS TO THEIR OFFSPRINGS
J. Experimental and Clinical Medicine, 2006, 6, pp. 22-24.
There are received 5 generations of rats (370 rats) via using close-relative crossing between 8 pairs of rats. Before crossing all of parential individual had been kept under chronical psychogenic stress conditions, which was revealed in the emotional anxiety.
To following generations revealed a high - degree anxiety before the formation of chronic psychogenic stress. We supposed, that in this occasion genetic ability for the anxiety condition increases.
HELICOBACTER PYLORI INFECTION IN PATIENTS WITH EARLY GASTRIC CANCER AND PRECANCEROUS DISEASES
J. Experimental and Clinical Medicine, 2006, 6, pp. 24-28.
National Center of Therapy, Tbilisi, Georgia
The discovery helicobacter infection has been recognized by many authors as one of the most significant achievements within the past 15 – 20 years. Helicobacter pylori proved to play an important part in the development of chronic gastritis, gastric ulcer, duodenal ulcer, extranodal B-cellular mucosa associated lymphoid tissue MALT-lymphoma and gastric adenocarcinoma. In 1994, the International Agency for Research of Cancer (IARC) categorized the helicobacter infection as a first-order carcinogen.
This article presents specific interactions between host and microorganism; the molecular bases of pathogenicity are described. The mechanisms of the development of chronic gastritis, gastric peptic ulcer, adenomatous polyposis and early gastric cancer are discussed. The significance of pre-cancerous Helicobacter pylori-associated diseases as premalignant pathology and probable perspectives of the development of complex preventive measures on prophylaxis of gastric carcinoma are surveyed.
7. PKHALADZE N., MAMAMTAVRISHVILI I., KALANDADZE I., DZNELADZE D.
PROGNOSTIC SIGNIFICANCE OF DETERMINATION OF PRO-INFLAMMATORY CYTOKINES IN WOMEN WITH ANTENATAL DEATH OF FETUS
J. Experimental and Clinical Medicine, 2006, 6, pp. 28-32.
K.Chachava Scientific Research Institute of Perinatal Medicine, Obstetrics and Gynecology;
I.Beritashvili Institute of Physiology, Georgian AS, Tbilisi, Georgia
The pro-inflammation cytokines of the IL-1, IL-6 and TNF-a types were studied by the method of immune-ferment analysis (IFA) in the blood serum and the isolated cervical canal in women with antenatal death of fetus. 40 patients suffering from this pathology were examined (the principal group) and 100 patients - of adequate age groups and periods of gestation, but with the presence of live fetus (control group). The results of the studies showed that the content of the pro-inflammation cytokines IL-1, IL-6 and TNF-a in the women in case of antenatal death of fetus was significantly higher in the blood, as well as in the isolated cervical canal than in the women with physiological progress of pregnancy. It should be stated that in the isolated cervical canal these indices were markedly higher compared with the cytokine concentrations in the blood, speaking of the appearance of the initial local response in the fetal-placental complex, after which the markers of these immune processes are exposed in peripheral blood.
The obtained data prove that the studies of cytokines of the isolated cervical canal may become an important method for the prognosis of antenatal death of fetus.
8. SIKHARULIDZE I., MAMPHORIA N.
PECULIARITIES OF WOMEN’S PHYSICAL DEVELOPMENT AND PELVIS FORM
J. Experimental and Clinical Medicine, 2006, 6, pp. 32-36.
A.Natishvili Institute of Experimental Morphology, Georgian AS, Tbilisi
K.Chachava Research Institute of Perinatal Medicine, Obstetrics and Gynecology, Tbilisi, Georgia
On the basis of K.Chachava Research Institute of Perinatal Medicine and Obstetrics/Gynecology, there have been studied peculiarities of physical development and pelvis form of 450 parturients. Physical development showed the signs of acceleration. The majority of the examined women belonged to the leptosomic type of the body constitution, comparatively rarely - to the mesosomic and leptosomic types. The pelvis of the gynecoid type had 218 women, pelvis contracted to different extents – 232 women. According to the constitutional type, the pelvis of the gynecoid type had mostly women of the mesosomic constitution, and contracted pelvis – women of the leptosomic constitution. Difficult confinement caused by pelvis form was noted in 50 cases and consequently cesarean section operations were performed. It’s necessary in obstetrical practice to fully examine a pregnant woman, work out a correct tactics for pregnancy observation and delivery management.
9. GABUNIA U., GARDAPKHADZE M.
THE IMPACT OF INFRARED CONTACT COAGULATOR ON THE ORAL CAVITY MUCOUS MEMBRANE
J. Experimental and Clinical Medicine, 2006, 6, pp. 36-38.
Department of Maxollafacial Surgery and Stomatology of Tbilisi Medical Academy, Georgia
In spite of various pharmacological preparations and methods used in the treatment of oral cavity mucous membrane wounds, physical approaches are not too numerous. In the current situation, when the sensibility of human body towards various pharmacological preparations has markedly increased, we aim to study the influence of the infrared contact coagulator on the oral cavity mucous membrane. The experiment was conducted an 10 male rabbits. Symmetric artificial lesions of mucous membrane using general anesthesia were performed. IKK was used only on the right side. The material was taken on the 2-nd,3-d,5-th,7-th day from the beginning of the experiment. The biopsies sectioned and prepared for histo-morphometric evaluation were studied using the light microscopy. Morphologic study demonstrated that in the group of animals treated with IKK application better restoration of all mucous membrane strata (epithelium, proper mucous membrane and undermucous layer) took place. The obtained results allow to claim that the application of IR contact coagulator does not hinder but to the contrary even favors the processes of the oral cavity mucous membrane regeneration and shortens the time needed for treatment.
IMMUNOLOGICAL PARAMETERS DURING POSTVACCINATION REACTIONS AND COMPLICATIONS
J. Experimental and Clinical Medicine, 2006, 6, pp. 38-40.
Pediatric Clinic of TSMU; Faculty of Specialization in Pediatry, Tbilisi, Georgia
The purpose of the work is to define immunological parameters during postvaccinal reactions and complications. The work has been executed on the basis of the retrospective analysis of immunologic parameters among 87 children at the age from 3 months to 14 years from the children’s pediatric clinic and 108 control persons of the same age. The statistical processing of the quantitative data included calculation of average arithmetic sizes and standard deviation. The authentic distinctions between the groups were made by Student’s coefficient . Mathematical support was carried out with the help of the applied programs package SPSS 11.5.
We have studied immunological parameters during postvaccinal reactions and complications. Our results have shown that during respiratory system complication, in comparision with control, there is observed the decrease in parameters CD3, CD4, B limphocytes, index immunoregulation. In the immunity there was marked an increase in concentration of IgG and IgM, and IgA decrease. In case of activation or at the beginning of reumatic diseases, comparatively decrease the parameters of CD3, and increase CD4, CD8 and immunoregulation index.
11. KALATOZISHVILI PH., GOGUADZE N., KOPLATADZE K., PAGAVA K.
PSYCHOLOGICAL INDICES IN CHILDREN WITH SHORT STATURE SYNDROME
J. Experimental and Clinical Medicine, 2006, 6, pp. 41-45.
Institute of Medical Biotechnology, Academy of Sciences of Georgia; Tbilisi Institute of General and Applied Psychology; Department of Endocrinology, Tbilisi State Medical University; 4Georgian-German Association of Pediatric Endocrinology, Tbilisi, Georgia
The aim of our study was determination of possible distinctive features in children with growth delay.
We studied 47 children having delayed growth (24 boys and 23 girls). Control group consisted of 45 children of normal height (16 boys and 29 girls). Age varied from 9 to 13 years.
The study was carried out using Lusher color test. The obtained data were analyzed by clinical features and sex. Results showed that there was no significant difference in dispositional psychological characteristics in children of both groups. Both groups equally needed outside support, approval and sympathy. Nevertheless, in spite of their importance, in children with growth delay these needs were suppressed. This may be accompanied by strain and impairment of attention and working capacity.
In both groups boys had well defined striving for autonomy and self-assertion. It was less expressed in girls with growth delay that was reflected in their low level of anxiety. It is possible to conclude that age-related “normal” difficulties are less important for girls with growth delay.
12. KAPANADZE N., CHICHINADZE N., SUMBADZE C., AMIRANIDZE M.
MORPHOFUNCTIONAL CHARACTERISTIC OF ADRENAL CORTEX DURING EXPERIMENTAL VIBRATION DISEASE
J. Experimental and Clinical Medicine, 2006, 6, pp. 45-47.
Al. Natisvili Institute of Experimental Morphology, Georgian AS, Tbilisi
After experimental vibration disease, on the 20th, 40th and 60th days of the experiment Disturbance, discirculation and and necrobiosis were observed. The part of the cortex where dystrophic changes are less observed is able to be functionally active that is confirmed by the hormonal study.
13. supatashvili t., gabunia u., mchedlishvili m.
ULTRASTRUCTURAL characterization OF BREAST CANCER PARENCHYMAL CELLS
J. Experimental and Clinical Medicine, 2006, 6, pp. 47-50.
A.Natishvili Institute of Experimental Morphology, Georgian AS, Tbilisi, Georgia
We studied the ultrastructural features of the breast cancer parenchimal cells in concordance with the cancer histogenesis, histological forms and malignancy rate. There are two types of the cancer cells by there ultrastructural study: first group of the cells has more differentiated forms than the second group. The first group of cells contains the ultrastructural features common to the normal breast epithelial cells: intracellular channels, secretory granules and myoepithelial cells.
For the second type of cells, in comparison with normal breast epithelial and differentiated forms of cancer cells are not characteristic premised ultrastructural features, but this type of cell cytoplasm is rich or poor in organelles.
14. KHATIASHVILI N., KVEZERELI-KOPADZE A., ERMAK I.
FUNCTIONAL CHANGE OF THE LIVER DURING TREATMENT OF HEMOLYTIC DISEASE OF THE NEWBORNS WITH INTERCHANGEABLE TRANSFUSION
J. Experimental and Clinical Medicine, 2006, 6, pp. 50-53.
G.Zhvania Pediatric Clinic of TSMU, Tbilisi, Georgia
The purpose of the given work is to study functional changes of the liver in newborns with hemolytic disease during treatment with replaceable transfusion.
The work is executed on the basis of a research of 87 newborns with hemolytic illness from the Pediatric clinic of STMU. On the basis of an open, unrandomized controllable research, there were biochemical parameters of a protein synthetic function of the liver investigated: AST/ALT, ALT/gGT, ALT/ALP, Al/g, Al/a2, Al/a1+a2, Al/a1+a2+g, Al/b, AST/gGT, AST/ALP, gGT/ALP, Al/a2+g. Defined absolute and relative risk of complication, number needed to harm - NNH. Mathematical support was accomplisched with the help of a package of the statistical programs SPSS 11-5. The received data showed, that after treatment, the biochemical parameters of a protein synthetic function of the liver decreased ALT/gGT, ALT/ALP, Al/g, Al/a2, Al/a1+a2, Al/a1+a2+g, Al/b, AST/ gGT, AST/ALP, Al/a2+g. Risk ratio of protein synthetic function insufficiency of liver RR = 9.17 (95%CI:1.2-66.2), ARI=0,25 (95%CI:0,11-0,38) NNH=1.98 (95%CI: 1.2-4.5), that specifies the liver of dysfunction.
15. MAKARADZE J., CISKARIDZE A., JANELIDZE M., SHAKARISHVILI R.
ANALYSIS OF EARLY CEREBRAL POST-STROKE CASE FATALITY ACCORDING TO THE BATUMI 1/9-98–1/01-2000 REGISTRY
J. Experimental and Clinical Medicine, 2006, 6, pp. 53-57.
P.Sarajishvili Institute of Neurology, Tbilisi, Georgia
Cerebral strocke is the most frequent cause of case fatality in the world’s adult population. The analysis of early post-stroke case fatality is important for the prevention of fatal stroke cases among the population.
Purpose: The purpose of our study was to analyse early post-stroke case fatality according to Batumi 1/9-98–1/01-2000 stroke registry.
Methods: We studied all the cases of primary stroke in Batumi for the period of 1/9-98–1/01-2000 by the method of prospective populative clincal-epidemiological study.
Results: One-month indices of the case fatality caused by primary ischemic stroke, intracerebral and subarachnoid hemmorhages, and undifferentiated stroke proved to be 26%, 81%, 46% and 53% accordingly. Early post-stroke case fatality for all the stroke types proved to be 41,5% which exceeded the so far existing analogical indices of the similar studies.
High indices of the case fatality caused by stroke among the Batumi population must be explained by the low level of stroke prevention, increase of the proportion of severe strokes, belated hospitalization, absence of specialized stroke service, low level of knowledge among the population about stroke as an urgent pathology.
16. SABAKHTARASHVILI T., GVENETADZE A.
DETECTION OF ECTOPIC PREGNANCY BY USING MODERN TECHNOLOGIES
J. Experimental and Clinical Medicine, 2006, 6, pp. 57-60.
Zhordania Institute of Human Reproduction, Tbilisi, Georgia
There were122 women aged 16 to 42 with the diagnosis of ectopic pregnancy under the observation, who in 1999-2004 addressed the I. Zhordania Institute of Human Reproduction.
All the patients, besides the general clinical – laboratory investigations, were examined for the amount of gonadotropin in the blood or urine, as well as underwent ultrasound examination and laparoscopy of the small pelvis cavity.
On the basis of the study results, it may be concluded that (a) the ultrasonic scanning as a non-invasive research method is highly informative in the ectopic pregnancy detection, especially as it enables a repeated observation; (b) laparoscopy represents the most informative and efficient low-damaging method; (c) the determination of gonadotropic khoriogonin in the urine or blood and consistent utilisation of ultrasonic scanning and laparoscopy provides a possibility of a guaranteed accurate detection of ectopic pregnancy.
17. GORGOSHIDZE B., KHARISCHARISHVILI I.
ISSUES OF MEDICAL ELEMENTOLOGY AND IMPORTANCE OF EXAMINATION OF TRACE ELEMENTS IN BIOSUBSTRATS FOR EARLY DIAGNOSIS, PREVENTION AND TREATMENT OF DISEASES
J. Experimental and Clinical Medicine, 2006, 6, pp. 60-64.
I.Zhordania Institute Of Human Reproduction, Tbilisi, Georgia
Here is presented the review of the physiological role of microelements in human health support, mechanism of action and reasons of exchange disorder. The general aspects of microelmentosis development and the importance of trace elements examination for early diagnosis, prevention and treatment.
18. SANIKIDZE E., VASHAKIDZE L., GHURTSKAIA N.
DETERMINATION OF HIGH-RISK GROUPS OF TUBERCULOSIS DEVELOPMENT IN THE POPULATION UNDER THE CONDITIONS OF MODERN SYSTEM OF TB CONTROL
J. Experimental and Clinical Medicine, 2006, 6, pp. 64-68.
National Centre for TB and Lung Disease,
Polyclinic for the Refugees from Abkhazia, Tbilisi, Georgia
Aim. To define high risk factors and their importance in development of TB in Georgia. To investigate distinct categories of population manifesting high risk groups of TB marking elaboration of practical arrangements.
Materials and methods. Medical documentation, 2 categories of population; straight interview, retrospective analysis, quantitative analysis of cause and effect relationship.
Resalts. During discussion of patient histories and estimation of questionnairs, there were cases singled out when the development of TB was ahead of existence of some risk-factor. According to the creation of the system for estimating risk, five groups of TB development were singled out. 2 categories of population were selected-1) employed intelectuals, 2) compactly settled refugees.
The risk-groups were defined by means of test-questionnaires. According to the pointing system It turned out, that there were some suspicious persons as a result of examination 3 person among them were fallen ill with TB. 3 years later, 3 representatives of high risk group were also taken ill with TB in the same category of population. Thus, mass screening of population by means of test-questionnaire is a cheap, convenient and informative method for manifesting risk groups. Preventive measures must be carried out in the bounds of different projects.
19. MIKABERIDZE D., CHICHINADZE N.
HORMONAL CHANGES TAKING PLACE DURING HEMORRHAGIC SHOCK
J. Experimental and Clinical Medicine, 2006, 6, pp. 68-71.
Al.Natishvili Institute of Experimental Morphology, Georgian AS, Tbilisi, Georgia
An experiment was performed on 35 adult dogs to determine male mammal’s reproductive system changes during hemorrhagic shock and results were studied. The conditions of experimental hemorragic shock were achieved in the animals by a graduate loss of 30% of the circulatory blood in an hour volume; microscopic sections made from the seminal glands were studied by various methods; the ultrastructur studies were performed by electronic microscopy; testosterone and follicle stimulating hormone plasma levels also were studied.
During experimental hemorrhagic shock, according to the animals’ different reactions three, groups were revealed: Group I – lethal outcomes: Group II – animals with increased reactivity, and Group III – animals with strong adaptive mechanisms. Hence we can resume that organism’s reaction on the aggressive factors, specifically on hemorrhagic shock, depends on individual compensatory mechanisms responses, which, in heir part, are due to the hypothalamo-pituitary-gonadal system state.
20. PACHKORIA V., BURKADZE G., KARAZANASHVILI G.
FREQUENCY OF PREDICTIVE FACTORS IN LOCALIZED AND NONLOCALIZED FORMS OF PROSTATE CARCINOMA ACCORDING TO HER-2/NEU POSITIVITY
J. Experimental and Clinical Medicine, 2006, 6, pp. 71-74.
Department of Tophographic Anatomy, Tbilisi Sate Medical University; Department of Pathological Anatomy, Tbilisi State Medical University; Department of Urology, Tbilisi Sate Medical University, Georgia
We have investigated 144 males with prostate cancer by radical prostatectomy. According to the postoperative materials of patho-morphological researches, the patients were devided into two groups: 1) 68 patients with prostate cancer of localized form 2) 76 patients with nonlocalized forms.
As the results of the immunohystochemical studies showed, HER-2/neu was not found in 47 patients of I group (69,1%) and in 14 patients of II group (18,4%).
Rates of proliferation markers, Ki-67 expression and other predictive factors were evaluated in the patients, classified by HER-2/neu positivity. In the Group I, Ki-67 was positive in 33 patients (48.5%), including 55.3% of the HER-2/neu-negative patients, 44.4% of the 1+ HER-2/neu-positive patients, 28.6% of the 2+ HER-2/neu-positive patients, and 20% of the 3+ HER-2/neu-positive patients. In the Group II, Ki-67 was positive in 44 patients (57.9%), including none from the HER-2/neu-negative patients, 11.8% of the 1+ HER-2/neu-positive patients, 85.7% of the 2+ HER-2/neu-positive patients, and all from the 3+ HER-2/neu-positive patients (p<0.05).
HISTOENZYMOCHEMISTRY AND ULTRASTRUCTURE OF YOUNG RATS CARDIOMYOCYTES IN SINGLE MAXIMUM-TOLERATED AND MODERATE PHYSICAL LOAD (RAPPORTE 2)
J. Experimental and Clinical Medicine, 2006, 6, pp. 74-76.
Azerbaijan State Medical University, Baku
The aim of the study is the assessment of morpho-functional changes in the cardiac muscle of various young age group animals under the conditions of different regimes of physical load.
Materials and methods of examination. The experiments were performed on white mongrel male rats. The age periodization was according to Zapadniuk V.P. classification (1971): 1) young age (5-10 months): a) preadolescent (22-50 days), mass 25,0-65,0 gr.; b) pubertal age (5-10 months, mss 120,0-250,0 gr.). Each age group included 30 rats, 120 animals in all. Physical load was modeled by forced swimming in a tall jug (t water 31-330C).
The following physical load regimes were used – a single maximum-tolerable load – swimming in a tall jug for 5 hours; multiple moderate physical load – swimming 2 times a week for 1,5-2 hours 1,3 and 5 months in the same conditions.
Results. In a single maximum physical load, young age (pubertal) (5-10 months, mass 120,0-250,0 gr) rat myocardium revealed an irreversible damages in sarcomeres including Z-bands fragmentation.
After 3 months of a moderate physical load the myocardium showed the increased and thickenned myofibriles, numerous ribosomes, glycogen wich indicates to the increase of energetic and plastic processes in cardiomyocytes.
22. G.KURASHVILI, M.K0KHTASHVILI, M.TODUA, K.SAGHRISHVILI, I.JAPARIDZE
CONTRIBUTION OF PHENE DIVERSITY OF GENETIC AND ECOLOGICAL FACTORS TO THE FORMATION DEVELOPMENT OF SONE INDICES OF CARDIOVASCULAR SYSTEM IN 12 TO 17 YEARS OLD TEENAGERS (TWINS STUDIES)
J. Experimental and Clinical Medicine, 2006, 6, pp. 76-82.
I.Javakhishvili Tbilisi State University, Faculty of Medicine.
198 couple twins between the age of 12 - 17 had been investigated. A Zygote was defined with the help of Siemens-Ferschwer’s polysymptomic method, blood investigation systems ABO, Rh, MN, P, Hp (haptoglobin) and also dermatogliphic and portrait identification method. 37 couple twins turned out to be monozygoted (10 couples masculine, 27 – feminine) and 62 couples – dizygoted (35couples masculine, 27-feminine). Also were investigated following activities: pulse frequency, an average arterial pressure, blood shock volume, blood minute volume, common peripheral resistance etc. Phenotypical dispersion of an aforesaid operation factor had been calculated on the basis of an inside class correlation calculations for mono- and diszygoted twins. It was discovered, that Genetic factor and specifically additive genetic component (G) plays a big role in forming of the investigated activities of the cardiovascular system.
Among the ecological factors, family factor (E) plays a decisive role. The coefficient of intercouple correlations between monozygoted boys were much higher, than between monozygoted girls; but between diszygoted couples- vice versa, what can point to the evolution direction of investigated characteristics.
23. NATROSHVILI N., NATROSHVILI T., MENABDE G.
COMPARATIVE ANALYSIS OF THE EFFECTIVENESS OF OZONE OIL - “OZONIDE” AND NON-STEROID ANTI-INFLAMMATORY DRUG - ORTHOPEN
J. Experimental and Clinical Medicine, 2006, 6, pp. 82-84.
Georgian Medical Academy, Tbilisi, Georgia
The abovementioned work was conducted on 55 patients who were separated into 2 groups. 20 patients of the I group were treated with Orthopen ointment - non-steroid anti-inflammatory substance. 35 patients of the II group were treated with the “Ozonide” - the ozone oil.
The conducted researches showed the results of treatment by Orthopen ointment and ozone oil.
The results proved the advantage of the ozone oil in comparison with the Orthopen ointment. It is expressed by the sharp improvement of clinical picture in 3-4 days. The indexes of HI, PMA, PI decreased, the bleeding from gums stopped, the teeth became more stable, the number of parodontic microbes also decreased.
The abovementioned clinical results were achieved by the treatment with Orthopen ointment in nearly 7-8 days.
24. MERMANISHVILI T., GABUNIA U.
MORFOLOGIC METHOD FOR ASSESSMENT OF INTRACRANIAL MENINGIOMAS GRAIDING
J. Experimental and Clinical Medicine, 2006, 6, pp. 84-86.
P.Sarajishvili Institute of Neurology, Tbilisi;
A.Natishvili Institute of Experimental Morphology, Georgian AS, Tbilisi, Georgia
The diagnostic criteria for histologic graiding and prediction of intracranial meningiomas behaviour are not clearly identified.The aim of the present study is an attempt to correlate the mitotic activity with meningiomas graid and recurrence. We reviewed 134 cases (87 women and 47 men) of completely removed intracranial meningiomas. !0-year recurrence was found in 46 cases (21 women and 25 men). The grade of tumor was assessed according to the World Health Organization classification (1997). We reviewed mitotic figures in 10 high-power field and calculated the mitotic index (MI). MI was identified as a number of mitosis in 1000 tumor cells. Our data suggest that MI is a significann criteria for the assessment of meningiomas grading and may be of value in predicting the behaviour of these neoplasms.