EXPERIMENTAL & CLINICAL MEDICINE
1.MACHAVARIANI P., GUSEV S., KORDZAIA D., DEKANOSIDZE T., BURKADZE G., JORBENADZE T., ALIBEGASHVILI T., SHAISHMELASHVILI G.
ASSESSMENT OF THE RISK OF ATHEROGENESIS IN NEWBORNS BY STUDYING THEIR UMBILICAL CORD BLOOD VESSELS
J. Experimental and Clinical Medicine, 2006, 8, pp. 9-12.
Institute of Cardiology, Tbilisi, Georgia; 2Institute of Physical-Chemical Medicine, Moscow, Russia;
Natishvili Institute of Morphology, Tbilisi, Georgia; 4Tbilisi Scientific-Practical Center of Pathology, Tbilisi, Georgia;
Maternity Welfare Clinic 18, Tbilisi, Georgia
Lipoprotein profile was studied in the serum of 52 selected pregnant women and in their umbilical cord blood. All 52 umbilical cord vessels were investigated by histological and immunohistochemical methods. In 32 cases the cholesterol was labelled in the endothelial cell plasmalemma via the specific cholesterol markers (SCM) consisting of polystyrene microspheres with digitonin on the surface. Quantity and distribution of cholesterol were examined by Scanning Electron Microscopy (SEM).
Two groups were selected according to the level of low-density lipoproteins (LDL): I) normal (LDL<3.0 mmol/dl) and II) risk group (LDL³3.0 mmol/dl). No other differences related to the parameters of histological and immunohistochemical studies were found in these groups.
In the normal group SEM investigation of SCM revealed low to moderate amounts of cholesterol of the endothelial plasmalemma in 88%; excessive amount - in 12%. The same data for the risk group represented 44 % and 55%.
2.RAHIMOV V., MUSAEV SH., GASANOV A.
PATHOMORPHOLOGICAL CHANGES IN LUNGS OF PATIENTS WITH SEVERE CRANIOCEREBRAL INJURY
J. Experimental and Clinical Medicine, 2006, 8, pp. 12-16.
Association “Forensic Medical Expertise and Pathologic Anatomy” of the Ministry of Health of Azerbaijan Republic; Clinical Medical Centre, Baku
To study the role of disseminated intravascular coagulation (DIC) in lung injury, and to determine the stages of respiratory distress-syndrome in patients with severe craniocerebral injury, there were investigated the corpses of 30 patients who died of severe craniocerebral injury. The researches showed that alterations in the microcirculation and aerodynamic barrier take the leading role in the development of respiratory distress syndrome in patients with severe craniocerebral injury. The circumscribed morphological picture confirmed the development of blood DIC in the first days after brain injury and the necessity of early intensive therapy.
3.KHOMERIKI I., SHIOSHVILI T., KIKACHEISHVILI E., BUKIA T., APRIDONIDZE K., JAMASPISHVILI T.
ETIOLOGICAL STRUCTURE OF INTRACELLULAR INFECTIONS IN CASES OF MALE URETHRITIS (WITHIN 2000-2004)
J. Experimental and Clinical Medicine, 2006, 8, pp. 16-19.
Departments of Urology, Microbiology – Epidemiology and Clinical-Laboratorial Diagnostics of Tbilisi State Medical Academy, Georgia
The aim of the research was to study the etiological role of Chlamydia, Mycoplasma, Ureaplasma, Herpes simplex virus, and CMV in cases of male urethritis from 2000 to 2004.
As a result of our research we conclude that Chlamydia trachomatis and Ureaplasma urealyticum are etiologically most important. At the same time the Mycoplasma hominis, Herpes and CMV play the role of additional pathologies.
The obtained results prompt the necessity of including anti-chlamydial and anti-aplasma preparations in the scheme of urethritis medical treatment.
INFLUENCE OF CALCILATE ON REGENERATION OF SOFT AND HARD TISSUES OF EXPERIMENTAL ANIMAL LOWER JAW
J. Experimental and Clinical Medicine, 2006, 8, pp. 22-26.
Tbilisi State Medical University, Georgia
There was studied the effect of daily injection of calcilate in different doses on the regeneration of the damaged soft tissues of adult white rats. Regeneration proceeded faster in comparison with the control group and formed cicatrix (scar), the volume of which was adequate to the volume of the lost tissue. This process was most optimally expressed in a series of experiments, when laboratory animals were receiving daily 300 mg of calcilate. For medical treatment of a defect of soft and hard tissues it is reliable to introduce calcilate daily. It is assumed to receive positive results using calcilate with the view of prevention and treatment (therapy) of diseases occurring during calcium deficit in the organism, especially periodontitis. For solution of expediency of experiment results extrapolation regarding humans, it is necessary to compare (confront) clinical and experimental data.
5. IMAMVERDIYEV S., AHADOV A., EFENDIYEV E.
THE URINARY DIVERSION PERFORMED FOR PATIENTS WITH MUSCLE INVASIVE BLADDER CANCER AFTER RADICAL CYSTECTOMY
J. Experimental and Clinical Medicine, 2006, 8, pp. 22-26.
Department of Urology of AMU, Baku
Bladder cancer is one of the most frequent tumors of the urinary system. For the most patients with muscle invasive bladder cancer radical cystectomy is performed. For the last 15 years there were performed 64 radical cystectomies in the Department of urology of the Azerbaijan Medical University. We performed urinary diversion into the sigmoid colon for 12 patients. The results of the operations were good so we recommend this method of urinary diversion after radical cystectomy to practicing surgeons.
6.SHENGELIA D., KARANADZE N., BALIASHVILI V.
THE USE OF ANTIOXIDANTS IN OPHTHALMOLOGY
Department of Ophthalmology, Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2006, 8, pp. 26-28.
Antioxidants play a major role in the maintenance of oxidative balance homeostasis. There are different ways of drug delivery in ophthalmology. Topical ophthalmic antioxidant drug delivery is most effective therapeutic way. Antioxidants are believed to protect humans from disease and aging.
7.LURSMANASHVILI Z., MZAREULISHVILI N., GVASALIA T., SUJASHVILI L., SHANAVA K.
EXPERIMENTAL MODELING OF CALCULOUS CHOLECYSTITIS USING MEDICAMENT “CLOFIBRAT”
J. Experimental and Clinical Medicine, 2006, 8, pp. 28-31.
Chair of Clinical Anatomy of Georgian State Medical Academy, Tbilisi
The diseases of cholecyst are characterized with high spread among the population, and their amount is permanently increasing. We must remark that reducing the frequency of these diseases is possible via complex prevention. This prevention must be done for the people who belong to the risk group of calculous cholecystitis development.
One of the risk-factors associated with calculous cholecystitis is the use of medicines to treat hypercholesterolemia, in particular, “Clofibrat”.
We decided to establish experimental model of calculous cholecystitis by using “Clofibrat”. Our main task was to find out the role of hypercholesterolemia medicines in the formation of cholecyst stone.
The researches revealed that using “Clofibrat” during cholestasis and using excessive cholesterol in the food caused stone formation in the cholecyst in 90% of cases. Using only “Clofibrat” and excessive cholesterol in the food without cholestasis caused 60% of the disease cases.
It is clear that using “Clofibrat” in certain conditions promotes stone formation in the cholecyst and represents a rather high risk-factor in calculous cholecystitis formation.
In conclusion, it is clear that using “Clofibrat” in certain conditions promotes to format stones in cholecyst and represents rather high risk-factor in formatting of calculous cholecystitis.
8. RAHIMOV V.
ROLE OF PLASMAPHERESIS IN INTENSIVE THERAPY OF ACUTE DISSEMINATED INTRAVASCULAR COAGULATION DURING SEVERE BRAIN INJURY
J. Experimental and Clinical Medicine, 2006, 8, pp. 31-36.
Azerbaijan Medical University, Baku, Azerbaijan
There were studied indexes of hemostasis in 45 patients in order to learn the influences of plasmapheresis used in addition to intensive therapy for patients with severe brain injury (SBI) and disseminated intravascular coagulation (DIC) which developed on 1, 3, 5, 7 and 9 days after the injury. It was found that using plasmapheresis in addition to intensive therapy for patients with SBI and developed DIC was conducive to rehabilitation of the level of anticoagulants (AT-III, Pr C), trombocytes, and reduction of microthrombs formation in organ and tissue vessels at the expense of product resolution of cells, aggregation of cells, product degradation of fibrin-fibrinogen complexes elimination.
9. SHANIDZE L.
PHARMACODYNAMICS OF HALOPERIDOL AND CYCLODOL
J. Experimental and Clinical Medicine, 2006, 8, pp. 36-39.
Institute of Psychiatry, Tbilisi, Georgia
The appointment of Cyclodol, as well as Haloperidol influence as that of a counteractive medicine should not coincide with the use of preparation Neurolepsy. It is advisability to give Cyclodol lately, only then, when it will be arised the incipience development of the Parkinson’s syndrome, light symptom.
10. KIRVALIDZE I., KHETSURIANI R., JORBENADZE T., SHUKAKIDZE A., ARABULI M.
THE INFLUENCE OF MEDICAMENT PREDUCTAL ON THE ULTRASTRUCTURE OF CARDYOMIOTITES DURING EXPERIMENTAL CARDIOMYOPATHY
J. Experimental and Clinical Medicine, 2006, 8, pp. 39-42.
Tbilisi State Madical University;
Scientific Practical Center of Clinical Pathology, Tbilisi, Georgia
The aim of the work was the inspection of the influence of medicament preductal on miocard ultrastructure during experimental autoimmune cardiomyopathy. Experiments were carried out on 30 male rats (180-200 g weight).
Their own researches have shown, that preductal has the positive effect to the miocard ultrastructural organization during experimental cardiomyopathy, which appeared in cardiomiotites, with the existence of a lot of quantity of unchangable structures, in comparision with non treated occasions. Also, the injure of mitochondries, miofibroses andoplasm radicals, mainly has hearth nature from above mentioned it may be concluded, that during the experimental cardiomyopathy, the improvement of miocard ability press, one of the effective means represents preductal.
11. DATESHIDZE L.
FOR FOUNDATION OF GEORGIAN MEDICAL DIALECTOLOGY
J. Experimental and Clinical Medicine, 2006, 8, pp. 42-54.
Institute of Medical Linguistics, Tbilisi, Georgia
The article is a formal declaration about foundation of a new direction Georgian Medical Dialectology (linguistics). The article has the references by Ph. D. Mikheil Kurdiani and Ph. D. Teimuraz Chigogidze.
Here is reviewed actuality, aims, objects, research methods, prehistory of the new directions foundation. This is a concluding article by Lali Dateshidze in medical linguistic field carried during 10 years in the framework of program Informational-Consulting System Georgian Medical Encyclopedia. These works are deposited in the previous magazine and is published with the electronic (CD) version.
12. DUNDUA T.
THE CONTENT OF HORMONES IN BLOOD PLASMA OF PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES MELLITUS
J. Experimental and Clinical Medicine, 2006, 8, pp.54-57.
Al.Natishvili Institute of Experimental Morphology, Tbilisi, Georgia
The level of somatotropin, tireotropin hormones and prolactin were measured in blood plasma of patients with non-insulin-dependent diabetes mellitus (NIDDM).
62 patients (28 males and 34 females) with NIDDM were examined. Their age ranged from 50 to 70 years. The patients were divided into two groups: the first group included 31 patients with NIDDM without diabetic retinopathy (DR); the second group included the same number of patients with NIDDM complicated by DR. At the time of investigation, their condition was decompensated (the blood level of glucose was increased at fasting). The control group included 31 healthy persons.
The research showed that NIDDM with DR is characterized by the expressed changes of pituitary hormones levels; NIDDM without DR - somatotropin and prolactin concentrations are increased, tireotropin is decreased. The data suggest that somatotropin, prolactin and tireotropin contribute to the development of diabetic microangiopathy in humans.
13. DOLIDZE N., KILASONIA L., BAGISHVILI N.
LOW NORMAL TSH LEVELS IN ASSOCIATION WITH BONE LOSS IN HEALTHY POSTMENOPAUSAL WOMEN
J. Experimental and Clinical Medicine, 2006, 8, pp. 57-59.
Bureau of Endocrinology and Metabolic Disorders at Medical company “TEST-House of Doctors”, Tbilisi, Georgia
Thyroid diseases and their treatment may be affective for the osseous system. The diagnosis of subclinical hyperthyroidism is based on the laboratory parameters meaning normal Free Triiodthyronine (FT3), normal Free Tetraiodthyroxine (FT4) and decreased Thyroid Stimulating Hormone (TSH). The influence of mild subclinical thyrotoxicosis on bone metabolism is still a matter of debate. Low normal TSH levels (examined by ultra-sensitive third generation methods) might also be related to bone loss. In this study we have assessed how low normal TSH levels affect bone mineralometric data. 95 caucasian healthy postmenopausal women divided into 5 groups according to TSH levels were assessed mineralometrically by DEXA HOLOGIC Explorer Series at the lumbar spine and femoral neck segments. Results showed that the occurrence of osteoporosis and osteopenia is greater with decreasing TSH levels.
14. DUNDUA T., SUMBADZE TS., JOJUA T., PAPAVA M.
ROLE OF GROWTH HORMONE IN PATIENTS WITH DIABETIC RETINOPATHY
J. Experimental and Clinical Medicine, 2006, 8, pp. 59-61.
Al. Natishvili Institute of Experimental Morphology of the Georgian AS;
Tbilisi State Medical University, Department of Ophthalmology, Tbilisi, Georgia
58 patients (26 males and 32 females) with non-insulin-dependent diabetes mellitus (NIDDM) were examined to determine the role of growth hormone (GH) in the development of diabetic retinopathy (DR). Their age ranged from 50 to 70 years, illness duration - from 1 to 3 years. The patients were divided into two groups. The first group included 29 patients (13 males and 16 females) with NIDDM without DR. The second group included the same number of patients with NIDDM complicated by DR.
15. ARUSTAMYAN K., BABAYAN K.
UROGENITAL CHLAMYDIOSIS IN WOMEN OF DIFFERENT SOCIAL GROUPS
J. Experimental and Clinical Medicine, 2006, 8, pp. 61-65.
Research Center of Maternal and Child health protection,
Medical Scientific Center of Dermatology and Sexually Transmitted Infections, Ìinistry of Health, Republic of Armenia, Yerevan
The aim of the study is to assess the frequency and clinical peculiarities of urogenital chlamydiosis (UGC) in women of different social groups.
Material and methods. 208 women aged 16-44 attended for termination of pregnancy (the 1st group) and 96 women were commercial sex workers (the 2nd group) (CSWs). They were investigated and questioned.
Results. The frequency of UGH among women of the 1st group was 9,6%, among CSWs - 18,2%( p<0,05). The abortion patients with UGC were urban citizens with high education, married. In this group of women infertility, spontaneous abortion (p<0, 05), two and more episodes of PID (p<0, 02) and STDs were registered. In the CSWs group the early beginning of sexual life, large number of sexual partners, low rate of contraceptive use, two and more episodes of PID and STDs, UGH association with other STDs were registered. High rate of UGH complications were registered in the 2nd group.
There is a need to increase the knowledge about STDs, their complications and consequences among the population. It is necessary to elaborate programs for early detection, adequate treatment and chlamydial infection control in the Republic.
Endocrinological and ophthalmological investigations were carried out. After that we measured the level of plasma GH by IFA. The data showed that the concentration of this hormone was increased. It suggests that GH contributes to the development of diabetic retinopathy in humans.
16. KEKELIDZE N., CHARKVIANI L., TSINTSADZE I., CHARKVIANI T., XARAISHVILI C., BUTSKHRIKIDZE V.
LYMPHOCYTES MANAGEMENT ACCORDING TO THE FORM OF UTERAL
J. Experimental and Clinical Medicine, 2006, 8, pp. 65-69.
A.Gvamichava National Center of Oncology, Tbilisi, Georgia
In the Gynecological Clinic of the Oncological National Center of Georgia frim 2002 to 2005 was performed 202 extended hysterectomy due to the carcinoma of cervix uteri. Retroperitoneal lymphocysts were revealed in 7,4%. Lymphocysts developed in 1,9% after non-peritonization of pelvic, and with peritonization in 5,4%. This complication is correlated with lymph nodes metastatic damages. Lymphocysts developed most often in III stage (16,6%), that in I (5,3%), II (10,3%) stages. Mostly lymphocysts are treated conservative therapy (53,3%). 20% of patients were punctured, microdrainage was performed and cocktail injection into the cyst cavity was made. In case of suppuration of lymphocysts resection and drainage was carried out.
17. TSISKARISHVILI N., KATSITADZE E., TSISKARISHVILI TS., TSISKARISHVILI N.
SOME PHYSIOTHERAPEUTIC METHODS FOR TREATMENT OF CHRONIC DERMATOSIS
J. Experimental and Clinical Medicine, 2006, 8, pp. 69-73.
TSMU, Department of Dermatology and Venerology, Tbilisi, Georgia
Physiotherapeutic methods of expose for treatment of skin diseases (Drug electrophoresis, Electric sleep, UHF, Ultrasound, Aerosol therapy, Phototherapy, Photochemotherapy, Combined methods of physiotherapy) were reviewed. General and particular contraindications of physiotherapy are observed, our own observations regarding efficacy of pulse current in complex therapy of patients suffering from alopecia areata are also cited as an example.
18. BUTSKHRIKIDZE M., VADACHKORIA G., MONIAVA E., KHANAEVA Z., SVANIDZE M.
MORPHOLOGICAL FEATURES OF NEURONAL ORGANIZATION OF SUPRAOPTIC AND PARAVENTRICULAR HYPOTHALAMIC NUCLEI UNDER WATER DEPRIVATION AND FOLLOWING WATER SATIATION OF AN ORGANISM
J. Experimental and Clinical Medicine, 2006, 8, pp. 73-76.
I.Beritashvili Institute of Physiology, Tbilisi, Georgia
The obtained data testify various reactions of neuronal populations of SO and PV nuclei in response to different periods of water deprivation. The recovery levels of structural metabolic components are different and depend on the functional peculiarities and on cellular compound of these nuclei.
19. SHKRIABAI V., KVARATSKHELIA T., GIORGADZE G., LAPAURI D., DATUASHVILI G., PIRVELASHVILI T., IASHAGASHVILI Z., LOBJANIDZE M.
TORSIONAL GENERATORS IN PROPHILAXY AND TREATMENT OF CHRONIC FATIGABILITY SYNDROME IN LIQUIDATORS OF CHAES
J. Experimental and Clinical Medicine, 2006, 8, pp. 76-79
Surgical Clinic of Tbilisi 14 Clinical Hospital, Georgia
Syndrome of chronic fatigability is revealed in the liquidators of Chernobyl atomic catastrophe. The effective means for treatment and prophylaxis of this syndrome is the “Torsion generator of longevity” of tertiary period.
20. MOSEMGVDLISHVILI M., METREVELI D., BAKURADZE L.
MICROBIAL SRTUCTURE OF THE ORAL CAVITY IN PATIENTS WITH GENERALIZED SEVERE PERIODONTITIS
J. Experimental and Clinical Medicine, 2006, 8, pp.79-83.
Stomatological Clinic of TSMU;
Department of Microbiology at TSMU
The cited data proves that the microflora of the oral cavity represents the most complex form of biocenosis, in which constantly coexist aerobes, facultative and obligate anaerobes presented by plentiful and varied species of gram-positive and gram-negative bacteria. Reasoning from the fact that any, even insignificant microbial imbalance can lead to the occurrence of different pathological conditions, the quantitative assessment of microbial associations seems to be a highly reliable criterion during differentiation of the oral cavity condition.
A comparison of the data obtained among the patients with periodontitis with the data in the control group (practically healthy persons) showed a significant difference in the microbial structure in the qualitative as well as quantitative correlation.
Thus, the concerned pathology most probably is conditioned by the consecution of the processes taking place in the oral cavity: disorder in colonizing resistance leading to microecological disorders on the teeth surface and gum mucosa; the intense reproduction of pathogens as a result of microecological imbalance causes the development of inflammatory-destructive processes in the mucous and root system of teeth, and the inhibition of immune reactions is accompanied by the pathologic process chronization and loss of teeth.
21. VASHADZE SH., KAPANADZE L.
ABOUT PANIC ATTACKS
J. Experimental and Clinical Medicine, 2006, 8, pp. 83-86.
Rustaveli State University, Batumi, Georgia
Ongoing processes in Georgia during last years caused intensive growth of number of psychophysical, dissadaptive patients. As human development is taking place in the constantly changing environment to which he has to adapt including social field. Among the most important reasons that cause the diseases are determined by the social, sociological, economical factors. The problem of vegetative nerve system pathology is always in the center of attention of neuropathology, psychologists and neurophysiologists, because any symptom-complex of any disease carries some sort of vegetative disorder of different intensiveness. The idea behind the article is via Hamilton scale to evaluate type of panic attacks and their ingredients in 50 healthy persons, as well as to assess serotonin indicator in the blood serum. We intend to discuss their connection and find the ways of prevention. Research was done by participation of 25 women and 25 men. Their age was between 18-70. 35 (70%) of them showed air shortage, pulsation increase in 24 (48%)-s, pain in the chest -15(30%), dizziness 25 (50%), loosing balance was noticed in 14 (28%), feeling of unreality in 15 (30%), parenthesis 35 (70%), filling of hotness in -33 (66%), sweatiness in -40 (80%), weakness up to the unconsciousness in -15 (30%), shivering in -33 (66%)s, fear of death of loosing mind, actions directed against their own will was observed in -5 (10%). Low level of serotonin was indicated in 60% researched patients, average in -8^%, and high only in 32%. From this we may conclude that during the inner anxiety and stresses panic attacks are perceived with the low level of serotonin and in case of depression - the high number of serotonin.
Therefore, physiological, physical, social and economical standards are putting high demands in front of the person. When the demands are higher than person can actually provide, which itself causes the dysfunction of adaptation, pathological reactions are developed. These reactions result creation of vegetative dysfunction, intensiveness of which is the reason of vegetative attacks number. In order to finalize the research of panic attacks it is essential to use serotonin analyzes in the clinics. This will help make the curing process easy and identify the preventive ways.
22. ROINISHVILI T., MARDALEISHVILI K., METREVELI D., NEMSADZE G.
THE ROLE OF TSH IN DEVELOPMENT OF MAMARY GLAND DISEASE
J. Experimental and Clinical Medicine, 2006, 8, pp. 90-91.
A.Gvamichava National Center of Oncology;
V.Iverieli Center of Endocrinology and Metabology, Tbilisi, Georgia
Thyroid gland (TG) has grate influence on female reproductive system. There is some clinical evidence of correlation between thyroid gland and breast diseases. It is well established that TG pathologic conditions increases risk of mastopathy, but mechanisms of such influence is not clear.
Aim of our study was to determine Thyroid Stimulation Hormone (TSH) parameters in women with mastopathy.
We investigated 90 women (47 with different TG pathology and 43 without). Different clinical and laboratory investigation was evaluated.
Our study reveals correlations between TSH, FT4, thyroid antigens and mastopathy. Risk of mastopathy is 2 fold increased in hypothyroid patients with high levels of TSH. We suggest that disturbances in TG hormonal balance causes pathophysiologic changes in breast tissue.
23. GAPRINDASHVILI N., TKEBUCHAVA K.
TREATMENT OF AMBLYOPIA WITH ELECTROSTIMULATION
J. Experimental and Clinical Medicine, 2006, 8, pp.90-91.
TSMU, Department of Ophthalmology, Tbilisi, Georgia
Patients with amblyopia were treated by the method of noninvasive electrostimulation and occlusion. The findings show a high efficiency of this combination.
There is no pain and no negative psychological effect for the patient. It is important to say that the result of treatment depends on the age of the patient.
24. ZAKARAIA C., GIGAURI T.
ECG CHANGES DURING VISCERAL LEISHMANIASIS
J. Experimental and Clinical Medicine, 2006, 8, pp.91-92.
S.Virsaladze Research Institute of Medical Parasitology and Tropical Medicine;
Union “Healthy Future”, Tbilisi, Georgia
Visceral leishmaniasis is a wide-spread parasitic disease in East Georgia. The authors have studied ECG in VL (100 cases). By investigating ECG, there were exposed some nonspecific changes of ECG: sinus tachycardia (91), prolonged PQ (38),T-depression (71).
25. NAVDARASHVILI A., ZAKARAIA C., GIGAURI T.
EBOUT SEVERAL ASPECTS OF BRUCELLOSIS TREATMENT
J. Experimental and Clinical Medicine, 2006, 8, pp.92
S.Virsaladze Research Institute of Medical Parasitology and Tropical Medicine;
The Union “Healthy Future”
Brucellosis still is a wide-spread zoonosic disease in Georgia. The authors have studied the role of Glucosamin and Chondzoitin sulfate in the treatment of human brucellosis (30 man). This research indicated the positive effect of Glucosaminsulfate application on the outcome and course of the disease, diminished relapse cases. During 6 month has not been fixed any deterioration of the osteoarticulare system. Remission in 6 months was 33,3%, in the control group - 11,5%.