EXPERIMENTAL & CLINICAL MEDICINE
2007, ¹ 4
1. CHKHIKVISHVILI I., GOGIA N., ESAIASHVILI M., GONGADZE M., KORSANTIA B.
ANTIOXIDANT ACTIVITY OF GREEN COFFEE AND VARIOUS SORTS OF ROASTED COFFEE
J. Experimental and Clinical Medicine, 2007, 4, pp. 9-11.
Institute of Medical Biotechnology, Tbilisi, Georgia
There were studied a quantitative content of Chlorogenic acid and other phenilpropanoids in green coffee and the antioxidative activity of these substances. It was established that green coffee contains a high percentage of chlorogenic acid and other phenilpropnoids that cause its high antioxidative activity. Consequently, green coffee is helpful for human health, and is recommended for any consumers as a new product.
The investigation of the quantitative content and antioxidative properties of chlorogenic acid and other phenilpropnoids in commercial black (roasted) coffee sorts showed that the results of the study could be useful for the determination of coffee quality according to the quantity of compounds useful to human health in it.
2.TODUA L., DVALI M.
CLIMACTERIC “DRY EYE” SYNDROME
J. Experimental and Clinical Medicine, 2007, 4, pp. 11-13.
Department of Ophthalmology, Tbilisi State Medical University, Georgia
“Dry eye” syndrome is one of the most frequent diseases in today’s ophthalmologic practice. It is rarely associated with systemic diseases. Hormonal changes during and after the menopause represent the most frequent cause associated with “dry eye”.
Purpose: Investigation of ophthalmologic complaints and stability of precorneal tear film 4-6 years after the menopause.
Methods: The study was carried out In 92 patients 4-6 years after the menopause.
Results and conclusions: The study shows that long-term estrogen deficiency causes the development of such dystrophic changes as in case of “Dry eye” syndrome.
3. AKHMEDOV E.
MODERN ASPECTS OF THE TREATMENT OF ARTHROSIS WITH INTERNAL DERANGEMENTS OF THE TEMPOROMANDIBULAR JOINT
J. Experimental and Clinical Medicine, 2007, 4, pp. 13-16.
Department of Oral and Maxillofacial surgery, Azerbaijan Medical University, Baku
Complex treatment of temporomandibular joint pathology is one of the actual and main problems in modern dentistry and maxillofacial surgery. We have used the Dona preparations (glucosamine sulfate) and Kortospan intraarticularly for the complex treatment of patients with simultaneous arthrosis and internal derangements. After the treatment, the condition of these patients normalized. Our tactics brought us to the positive clinical effect and improvement of patients’ life activity.
4. LOMSIANIDZE T.
DIAGNOSIS AND EFFICIENCY OF TREATMENT OF CHRONIC INFLAMMATORY DISEASES OF FEMALE SMALL PELVIS ORGANS IN OUT-PATIENT DEPARTMENT
J. Experimental and Clinical Medicine, 2007, 4, pp. 16-19.
A.Tsereteli Kutaisi State University, Georgia
Among the women who were admitted to the female consultation over the 2000-2006 period a significant place occupy inflammatory processes of the female sexual sphere.
265 women were diagnosed and treated in the gynecological out-patient department and were studied concerning chronic inflammation of small pelvis organs.
Diagnosis and treatment were carried out individually and according a certain algorithm.
The received results showed:
1. The treatment of chronic endometritis and chronic salpingitis is effective only during the complex approach.
2. A high level of recovery is marked only in the group of women who underwent purposeful antibacterial therapy.
3. The treatment was highly efficient in the women with one leading nosology.
4. A large importance has the process of rehabilitation and treatment of the sexual partner.
5. SHADLINSKAYA S., MOVSUMOV N., KERIMOVA L.
MICROSCOPIC DESCRIPTION OF LYMPHOID STRUCTURES IN FALLOPIAN TUBES DURING TUBAL PREGNANCY
J. Experimental and Clinical Medicine, 2007, 4, pp. 19-23.
Azerbaijan State Medical University, Department of Obstetrics and Gynecology
The purpose of this research was to detect morphological peculiarities of lymphoid structures in the fallopian tubes during tubal pregnancy (5-7 weeks).
The tubal mucous membrane was researched by means of macroscopic and histological methods (6 cases of surgery material). To compare of the received data lymphoid structures from 8 non pregnant women (group of comparison) were examined. After standard processing, the cuts for microscopic examination were stained with hematoxylin-eosin, picrofuchsin by Van Gison, by Kreiberg, azur-2-eosin, rezorcin-fuchsin by Veigert. The data were analyzed by Student’s t-criterion.
The results of research showed that during tubal pregnancy (5-7 weeks’ period) there occurs an activation of the lymphoid apparatus of the germinal centre development, and an increase in cell quantity of all the lymphoid structures of the organ, increase of juvenile forms of lymphoid row, plasmocytes, macrophages combined with the enlargement in thickness of mucosal and muscular membranes of the fallopian tube.
6. KVEZERELI M. 1, 3, PANTSULAIA I.1, 2, KIKODZE N.1, 2, IOBADZE M.1, CHIKOVANI T.1, 2
MATURATION OF BONE MARROW-DERIVED DENTRITIC CELLS
ENHANCED BY PLAFERON-LB
J. Experimental and Clinical Medicine, 2007, 4, pp. 23-25.
1Institute of Medical Biotechnology; 2Tbilisi State Medical University, Georgia;
3Stanford University School of Medicine, USA
Dendritic cells are specialized, bone marrow-derived leukocytes critical to the onset of both innate and adaptive immunity. The divisions of labor among distinct human DC subtypes achieve the most effective balance between steady-state tolerance and the induction of innate and adaptive immunity against pathogens, tumors, and other insults. Maintenance of tolerance in the steady state is an active process involving resting or semimature DCs. Breakdowns in this homeostasis can result in autoimmunity. Plaferon LB is a mixture of peptides derived from human placenta, which has the anti-inflammatory, antiviral and immunomodulatory effects. Based of above-mentioned, the main aim of our study was to evaluate the influence of PLB on the phenotype bone marrow–derived murine DCs.
We showed that Plaferon LB-treated DCs up-regulate the expression of major histocompatibility molecule I-Ab. Furthermore, the PLB treated DC population expressed even higher level of I-AB than LPS stimulated DCs. Thus, PLB activates DCs and promotes the maturation of DCs. Taking into consideration our and previous results, PLB might be a potential immonomodulatory drug not only against infection, but also tumor.
7. GUSEYNOV B.
MACRO-MICROANATOMIC DESCRIPTION OF THE TRACHEAL AND BRONCHIAL GLANDS
J. Experimental and Clinical Medicine, 2007, 4, pp. 25-29.
Azerbaijan Medical University, Department of Human Anatomy, Baku
The aim of the present research was to analyze microstructural peculiarities of the tracheal and bronchial glands in persons of different age.
Tracheal glands and glands of bronchus principles were studied in the corpses of 126 persons of different age who had no pathology of respiratory organs, chronic venous congestion.
Microanatomy was studied on the miscroscopical slides. 5-7 µ thick cuts were colored with hematoxylin-eosin, by the method of van Guison, reaction of silvering by Grimelius.
The conducted research showed that glands of membranaceous and cartilaginous parts of the trachea and bronchus principalis, being tubuloalveolar in composition, differ in form and topography. While the glands located in the membranaceous part are oblong, round, oval and irregular in shape, the initial parts in the cartilaginous wall are oval, fan-shaped and flattened.
Glands that have the smallest parts are located in the cartilaginous wall. Glands that have lager initial parts are observed in membranaceous wall of the trachea and bronchus principles.
It is revealed that the initial parts of the glands and both bronchi consist of the parenchymal and stromal components. Parenchyma of the glands is presented by the initial and proximal parts of the duct. Stroma is presented by loose fibrous tissue; in the reaction of silvering the argirophilic fibers are revealed.
8. CHKHIKVISHVILI I., GOGIA N., GONGADZE M., ESAIASHVILI M., KORSANTIA B.
CONTENT OF RESVERATROL AND ANTOCYANS IN VARIOUS SPECIMENS OF GEORGIAN WINE
J. Experimental and Clinical Medicine, 2007, 4, pp. 29-31.
Institute of Medical Biotechnology, Tbilisi, Georgia
For display of a sort of wine, it is worldwide accepted to study polyphenol (anthocyanins etc.) and resveratrol content in it, because these compounds determine the preventive and curative properties of wine. The aim of our study was to investigate anthocyanins and resveratrol percentage in some specimens of Georgian wine and to establish its correlation with a comparative antioxidative activity. Our results has shown that Dirgula and Pino contain high quantities of resveratrol (5.22 and 3.96 mg/l respectively); next are Saperavi and Aladasturi (1.44 and 0.98 mg/l respectively); Tavkveri, Adesa and Rkaciteli contain low quantities of resveratrol. Resveratrol content correlates with wine antioxidative activity, what we can not say about anthocyanins content. We can conclude that resveratrol is a major cause of the antioxidative effect of Georgian wines - their health-giving content is competitive with the wine sorts well-known in the world.
9. BABAEV E., SLINKO E., ZOLOTOVERKH A.
POSTERIOR MICROFORAMINOTOMY AS A METHOD FOR THE OPERATIVE TREATMENT OF CERVICAL RADICULOPATHY
J. Experimental and Clinical Medicine, 2007, 4, pp. 31-34.
P.Shupik National Academy of Post-Graduate Education
Over the 2001-2006 period, 10 patients with cervical stenosis were treated surgically. They were diagnosed on the basis of clinical data, myelography, CT and MRI. All the patients underwent microforaminotomy. In the early postoperative period there was noted a reduction or disappearance of pain in 10 patients, reduction of segmental and radicular disorders - in 8 patients. 1 patient suffered from a permanent aggravation of neurologic semiology, while such semiology in 2 patients was improving rapidly.
10. CHIKVILADZE D., METREVELI D., MIKELADZE M., GACHECHILADZE KH., IOSEBASVILI T.
BACTERIAL-FUNGAL ASSOCIATIONS IN THE INTESTINE UNDER THE CONDITIONS OF COLON IZATION BY YEAST-LIKE FUNGI OF THE GENUS CANDIDA
J. Experimental and Clinical Medicine, 2007, 4, pp. 34-38.
Tbilisi State Medical University, Department of Microbiology and Immunology, Georgia
There have been analyzed a composition of fecal microflora in somatic patients and patients with enteric infections under the conditions of surplus colonization by yeast-like fungi of the genus Candida. The study revealed that a high level of fungal contamination was linked with decreased resistance to bacterial colonization in the intestine (deficiency in bifidoflora), and with the presence of opportunistic microorganisms: Staphylociccus aureus, hemolytic and lactose-negative Escherichia coli, as well as nonfermenting gram-negative bacteria. The antilysozyme activity of enterobacteria was found to increase in the course of their joint cultivation with fungi of the genus Candida that may be regarded as one of the mechanisms of the formation and maintenance of pathobiocenosis.
11. KURBANOVA H.
USE OF COMPUTER TOMOGRAPHY AS A MODERN DIAGNOSTIC METHOD FOR WOUNDS OF POSTERIOR POLE OF EYE
J. Experimental and Clinical Medicine, 2007, 4, pp. 38-40.
A.Aliev Institute of Post-Graduate Education, Department of Eye Diseases, Azerbaijan, Baku
Aim of investigation. To study the possibilities and perspectives of CT use in diagnosing traumatic damage to the posterior pole of the eye.
Material and methods. The study was conducted on 20 patients who were treated in the department of traumatology and reconstructive surgery of Helmholtz Moscow SRI of Eye Illnesses over the 2002-2003 period with suspicion of non-diagnosed disruption of the external coat in the posterior pole part of the eye.
Results. Fresh and partly treated disruptions of the external coat in the posterior pole part of the eye were diagnosed due to the data of CT, and allowed us to choose an adequate tactics for surgical and conservative treatment and to gain an organ-protecting effect in 98.5% of the patients with more serious pathology as a result of mechanical trauma of the eye.
12. ASLAMAZISHVILI T., KORDZAYA D., SHAISHMELASHVILI G., PHARCAKHASHVILI J., KURELI I., JANGAVADZE M.
PROLIFERATION OF BILIARY EPITHELIAL CELLS IN EARLY SRAGE OF CHOLESTASIS
J. Experimental and Clinical Medicine, 2007, 4, pp. 40-43.
Al. Natishvili Institute of Morphology
Ductular reaction was studed ½, 1, 2, 3, and 6 hours after common bile duct ligation (BDL) in Wistar rats. Cholangiocyte-like cell proliferation was revealed in the periportal area one hour after the BDL, and was maintaned throughout the study. At the same time, no mitotic figures were found.
Evidently, rising biliary pressure induces ductular reaction. The possible reasons for the formation of bile ductular-like structures may be: 1. Bone marrow derived stem cells transition into the liver tissue with further differentiation into ductular cells; 2. Proliferation of liver stem cells and their transformation into the biliary epithelial cell linage (possibly, via passing the oval cell stage); 3. Transformation of “small hepatocytes” or endotheliocytes into ductular epithelial cells; 4. Proliferation of the existing cholangiocytes.
The absence of mitosis may be caused by changing of the terms and conditions of the early response genes expression in ductular epithelial cells due to biliary hypertension, as it takes place in hepatocytes after simultaneous partial hepatectomy and BDL.
According to these data, there is supposed a further investigation of pathogenesis of ductular reaction within the first hours after BDL with immunohistochemichal markers for celltyping and proliferation.
13. JABBAROVA N.
COMPARISON OF AREAS OF INITIAL PORTIONS OF GLANDS IN DIFFERENT PARTS OF FEMALE URETHRA
J. Experimental and Clinical Medicine, 2007, 4, pp. 43-46.
AMU Department of Human Anatomy, Baku
The goal of the given work was to study the area of the initial portion of the urethral glands. There was used material taken from the corpses of 26 persons of different age and the resorcin-fuchsin staining method, the Van Gieson and Kreyberg methods, and the Veygert method of staining with hematoxylin-eosin.
It was stated that the area of the gland initial part enlarges in the distal middle portion irrespective of the age. It must be noted that the area of the glands initial portion in the internal sphincter is less than in the area of external sphincter. Age-dependent changes of the given index are as following: the area of the initial parts of the urethral glands gradually enlarges over the I period of childhood, reaches its maximum in mature women, and gets considerably smaller at older age.
14. GIORGADZE I., GAPRINDASHVILI N., TOPURIA N., TKEMALADZE L., GIORGADZE M., SABAURI N., AKHALAIA E., TKEBUCHAVA K.
THE ROLE OF ADENOVIRUSES IN EYE INFECTIOUS PATHOLOGY
J. Experimental and Clinical Medicine, 2007, 4, pp. 46-49.
G.Eliava Institute of Bacteriophage, Microbiology and Virology, Ltd ”Diagnosis-90”;
N.Kipshidze Central University Clinic, Tbilisi, Georgia
Viruses and Bacteria cause acute and chronic conjunctivitis. Acute viral conjunctivitis essentially has an adenoviral etiology. Adenoviruses have the capacity to exist long and latently, and to exert an immunodepressive effect on the organism. The main goal of our work was differential diagnosis of adenoviruses in the patients infected with acute conjunctivitis and to reveal the leading and important associations of pathogenic microorganisms in the case of mono, as well as mixed infections. This study was conducted to plan etiotropic treatment. According to the received results, adenovirus has been revealed in 51.55% of cases (women and patients above 30 made up more than half of this contingent). Adenovirus is well treated via interferon and its inductors, bacteriophages and antibiotics. These preparations should be selected individually to allow the doctor to achieve a high therapeutic effect.
15. MIKADZE M., TCHARKVIANI T.
DIAGNOSIS AND TREATMENT FOR RARE FORMS OF CANCER OF THE UTERINE BODY
J. Experimental and Clinical Medicine, 2007, 4, pp. 49-52.
Gvamitchava oncology Center of Georgia, Tbilisi
In the gynecological department of the Oncology Center over the 2000-2004 period were being treated 41 women with rare forms of cancer of the uterine body. During that period there were 407 patients being treated with the diagnosis of cancer of the corpus uteri (ratio 1:6.1).
Though it is accepted that rare forms of cancer (papillary cancer, in particular), unlike the endometrial forms, are more characteristic of the older women.
Attention has been drawn to the fact that in Georgia there is a notable age rejuvenation in patients with rare forms of cancer of the corpus uteri.
The peak of morbidity, according to the research data, comes between the ages of 55 and 67.
But among the patients with diagnosis of cancer of the corpus uteri, who sought medical help in the Oncology center, the youngest patient was 34 years old (papillary center of the corpus uteri), and the oldest – 68 (papillary center of the corpus uteri). In Georgia, the average age when it is possible to develop the rare forms of cancer of the uterine body is 59 (less than the age typical for the deceased).
16. TURMANIDZE T. R., CHIKVILADZE D. P., GACHECHILADZE KH. E., MIKELADZE M.L., METREVELI D.A.
MICROBIAL COLONIZATION OF ORAL CAVITY IN PATIENTS WITH HEMOBLASTOSES
J. Experimental and Clinical Medicine, 2007, 4, pp. 52-56.
Tbilisi State Medical University, Department of Microbiology and Immunology;
Stomatologic Clinic “G&N-dent”, Tbilisi, Georgia
There was microbiologically investigated the oral cavity of 54 patients with hemoblastoses (19 men and 35 women, aged 16 to 75).
47 patients (87.03%) with confirmed clinical diagnosis of hemoblastoses of different types had the inflammatory process in the oral cavity. Quantitative and qualitative microbiological analysis revealed marked changes in the oral cavity microbial flora biocenoses, imbalance between normal and conditionally pathogenic microorganisms. Ps. aeruginosa (16%), K. pneumoniae (12.2%), H. influenzae (7.6%), E. coli (6.1%), S. aureus (20.6%), Str. pneumoniae (14.5%), Str. pyogenes (12.9%), and Candida albicans (9.9%) were isolated. In some cases microorganisms were isolated in different microbial associations. Gram-positive microorganisms exceeded gram-negative ones 1.4 times. The degree of microbial colonization was high – it ranged between 104-107 CPU (colony producing unit in 1 ml of saliva).
Determination of the antibiotic sensitivity of an isolated microorganism revealed the following: the most effective are ceftazidim, amikacin, piperacilim, avelox, meronem, ciprofloxacin.
Microbiologic investigation of the oral cavity of patients with hemoblastoses is a valuable diagnostic criterion which enables rational prophylaxis and treatment of such pathologic processes without any complications like secondary immune deficiency related with the main pathology.
17. RAMAZANOV Z., ABIDOV M., ESAIASHVILI M., CHKHIKVISHVILI I.
EFFECT OF BLUDIABIN ACTION ON BLOOD PLASMA GLUCOSE (DOUBLE BLIND PLACEBO CONTROLLED METHOD)
J. Experimental and Clinical Medicine, 2007, 4, pp. 56-59.
1National Bioscientific Corporation USA;
2Center for Modern Medicine, Ministry of Health of Russia, Moscow;
3Institute of Medical Biotechnology, Ministry of Education and Science of Georgia
Clinical researches were carried out to study the influence of the herbal preparation Bludiabin and blueberry leaf extract containing low 4% concentration of chlorogenic acid on the glucose in human blood plasma. It was established that Bludiabin is able to affect glucose in the blood plasma – reduce its level after meals: this property is determined by 18% content of chlorogenic acid in it. We can conclude that the sugar-lowering effect of blueberry leaf extract depends on the concentration of chlorogenic acid in it.
18. TSABUTASHVILI A., BARABADZE K., AKHVLEDIANI I.
TROPONIN-I AND CARDIAC AUTOANTIBODIES VALUES FOR DETECTION CARDIOVASCULAR SYSTEM DAMAGE IN CHILDREN SUFFERING FROM CHRONIC TONSILLITIS
J. Experimental and Clinical Medicine, 2007, 4, pp. 59-61.
Tbilisi State University, Chear of Pediatric
80 patients were observed not older than 15 years. Cross-sectional study was held. The patients were divided into main and control group; cardiac Troponin-I was measured in serum applying ELISA. Cardiac autoantibodies- applying immunofluorescence method. Significant rise in level of biochemical marker Tp-I was observed in serum; Cardiac autoantibody test was positive in 44%, which indicates on the autoimmune feature of the disease. The study allows to use investigated markers as the diagnostical criteria at the time of tonsillogenic cardiovascular pathology in children, to held timely and adequate treatment in aim of prevention of the disease.
19. GABUNIA L., ARZIANI B., PETRIASHVILI SH., SHANIDZE L., VARDISANIDZE T.
COMPARATIVE INFLUENCE OF LISINOPRIL AND LOSARTAN ON RAT HEART ISOLATED BY THE LANGENDORFF METHOD IN THE CONDITIONS OF ISCHEMIA AND REPERFUSION
J. Experimental and Clinical Medicine, 2007, 4, pp. 61-65.
TSMU Central Clinic, Georgia
Nowadays it is known that ACE inhibitors are gold standards of treatment of the arterial hypertension and heart failure disease but the outlook of Renin - Angiotenzin System s inhibitors is interesting in treatment and prevention of heart ischemic disease and it’s complications.
The aim of our research was to learn the comparative influence of Lizinopril and Lozartan on myocardial resistance on the different parameters of the isolated heart of the rat .(the frequency of heart’s contraction , rhythm, volume speed of coronary stream ) in the condition of ischemia and reperfusion. The research was carried out by the method ot Langendorf.
In our experiment we used the bred less, white rats (n=30; weight 250-300g) on the 21st day after cutting the rat’s chest we separated the heart under the anesthesia and heparin administration. Then we removed it quickly and hanged it on the specially modified device and started perfusion by Krebs-Hencelait’s solution. After the stabilization of the isolated heart’s work we modificated low-stream global ischemia by the above mentioned method with reperfusion . The received results were elaborated by the PC program “Biostatistics”. The reliability of the results were calculated by the “Student” according to the criteria – t.
Our experience shows that Lozartan increases the resistance of the myocardium against the ischemia and reperfusion.
20. PURTSELADZE N.
INFLUENCE OF TREATMENT WITH VARIABLE MAGNETIC FIELD OF LOW FREQUENCY ON BIOCHEMICAL INDEX OF PATIENTS WITH ESSENTIAL HYPERTENSION
J. Experimental and Clinical Medicine, 2007, 4, pp. 65-68.
Tbilisi Balneological resort, Scientific-practical centre of balneology, physiotherapy, rehabilitation and medical tourism of Georgia, Tbilisi
68 patients with essential hypertension were investigated. From this amount of patients in 32 discovered disease of I stage and in 36 patients – the II stage.
The conducted studies with patients with mentioned pathology uncovered weakening of system of antioxidant protection, strengthening of processes of peroxide description of lipids and disturbance of lipid exchange. These processes were progressive among weighting of disease.
The treatment by variable magnetic field of low frequency (50 Hertz) and by induction in 30 MTL in patients with essential hypertension caused the strengthening of system antioxidant protection, oppression of peroxide oxidation of lipid and normalized disturbance of lipoids. The mentioned progresses which were more expressed in I stage of pathology were attended by increasing of catalage activity, decreasing of amount of malonie diadehyde in blood plasma and cholesterol in β lipoproteins; by decreasing of substance in scrum of blood of total cholesterol, total lipids, triglycerides and in β lipoproteins; by increasing in scrum of blood in frame of norm, substance of lecithin.
21. RUSADZE N., GALDAVA G.
PHARMACOECONOMICAL ASPECTS OF TREATMENT FOR UROGENITAL CHLAMYDIOSIS IN ANDROLOGY PRACTICE
J. Experimental and Clinical Medicine, 2007, 4, pp. 68-73.
Tbilisi Research Institute of Dermatology and Venerology,
Medical Faculty of Tbilisi State Medical University, Department of Dermatology and Venerology
Urogenital chlamydiosis is one of the most common sexually transmitted diseases. 50-70% of urogenital tract diseases are caused by Chlamydia and Ureaplasma. The problem of treatment of such a pathology still remains complex.
187 men aged 19 to 46 with chronic urogenital chlamydiosis were under observation, duration of the disease - 2 to 8 years. We compared three most commonly used treatment methods.
Method 11(36 patients) - Glutoxim 1% 1,0ml N10-1 vial daily, Vilprofen-500 N30- 1 tab twice a day.
Method 12 (71 patient) - Cycloferon N10 (widely recognized technique), Cyprobay -500 N30 1 tab twice a day.
Method 13 (80 patients) - Cycloferon N10(widely recognized technique), Sumamed 0,25 N20 1 tab twice a day.
Research has shown that a) - an absence of side effects and complications with antibiotic therapy proves the ability of Glutoxim to prevent an immunosuppressive effect of antibiotics; b) - an absence of the signs of chlamydiosis in laboratory reports (bacteriologic analysis, PCR, serology) due to the affect of Glutoxim on intacellular bacterial forms (apoptosis) and reinforcement of the effects of antibiotic therapy (suppression of resistance).
Thus, the use of Glutoxim-Vilprofen in the treatment of urogenital chlamydiosis is most effective, considering clinical and pharmacoeconomical data.
22. CHKHAIDZE Z., TOMADZE G., SOLOGASHVILI T., PARTSAKHASHVILI D., KHODELI N.
USE OF UNCONVENTIONAL PERFUSION SYSTEM IN EXPERIMENTAL LOBULAR TRANSPLANTATION OF LIVER
J. Experimental and Clinical Medicine, 2007, 4, pp. 73-77.
Scientific Center for Experimental Surgery, Training and Education, A.Natishili Institute of Morphology, Tbilisi, Georgia
There have been developed the unconventional perfusion system (UPS) and method of circulatory support of the recipient organism and donor organ durIng lobular transplantation of the liver in the experiment. There were offered circuits of connections of UPS to the transplant, with the purpose of its preservation, as well as to the recipient for the optimal circulation support of the recipient’s organism (CSRO).There were registered temperature, blood flow outlay, arterial and venous pressure in different segments of perfusion system.
In the process of preservation of donor’s liver lobe, normal hemodynamic parameters were registered, testifying the maximal physiological total blood flow in the transplantat during normothermia. Due to CSRO, the necessity of jugular veins canulation disappeared and full return of blood was provided during intraoperational bleeding of any intensity with preservation of an adequate blood-flow in the remained lobe of liver.