J.EXPERIMENTAL & CLINICAL MEDICINE
2010, ¹ 1
1. Azmaiparashvili E., Geldiashvili M., Chkhaidze Z., Khodeli N.,
Pilishvili O.,Tomadze G., Jangavadze M., Partsakhashvili J., Kordzaia D.
Optimization of Venous Return during the Anhepatic Phase of Experimental Liver Transplantation
J. Experimental and Clinical Medicine, 2010, 1, pp. 9-14
Center for Research, Education and Training in Experimental Surgery, Al.Natishvili Institute of Morphology; Department of Clinical Anatomy and Operative Surgery, Faculty of Medicine, I. Javakhishvili State University, Tbilisi, Georgia
To assess the effectiveness of different schemes of veno-venous bypass during the anhepatic phase (AP) of experimental liver transplantation, experiments have been performed on 8 male dogs weighing 15–20 kg. After hepatectomy, a pump-driven venous bypass from the infrahepatic segment of the caudal vena cava and portal vein was conducted into the brachiocephalic vein (I group; n=4) or the suprahepatic segment of the caudal vena cava (II group; n=4). Hemodynamics was monitored for 3 hours.
During the entire AP in the I group the pressure in the cranial venous system was increasing (p>0.05), while the blood flow index was decreasing (p<0.05); the same parameters in the II group were maintained unchanged.
The obtained results confirm that veno-venous bypass into the suprahepatic segment of the caudal vena cava can be considered as more physiologic and can prolong a safe AP up to 3 hours.
2. Bayramov G.
STRUCTURE AND ETIOLOGICAL IMPORTANCE OF PERIODONTOPATHOGENIC MICROFLORA IN THE FORMATION OF INFLAMMATORY DISEASES OF PARODONTIUM
J. Experimental and Clinical Medicine, 2010, 1, pp. 14-19
Department of Therapeutic Stomatology, AzSMU, Baku
A microbiological research has been conducted among the patients with different clinical forms of inflammatory diseases of parodontium (IDP) and persons with healthy oral cavities. It was established that normal as well as periodontopathogenic microflora is formed by associations of different types of microorganisms distinguished by high priority and planting. Allocation of prepotent kinds of activators for each clinical form allows choosing the optimal selective tactics effectively providing eradication of activators. Specification of prepotent representatives of normal microflora opens wide prospects in the increase of the efficiency of conservative treatment for IDP. Artificially introducing these dominants into the oral cavity by means of bacteriofags, it is possible to create intolerable ecological conditions for the vital functions of periodontopathogenic microflora.
3. Israfilova S., Gafarov Ch., Mamedov R.
Preventive maintenance and complex therapy foR tracheaL cicatricial stenosis usING diprospan and infrared low-intensity laser radiation
J. Experimental and Clinical Medicine, 2010, 1, pp. 19-22
Department of General Surgery, Azerbaijan Medical University, Baku
The frequency of cicatricial stenosis of the trachea continues to grow, which can be explained by a wide application of long-term artificial ventilation of the lungs. However, the consequences of this manipulation very negatively affect the tracheal wall, which subsequently cause the formation of cicatricial stenoses. The methods offered earlier are not successful in relieving this complication. Depending on the terms of postintubation and posttracheostomy stenosis, our patients have been divided into 2 groups: early complications – about 3 months (38 patients) and later complications – more than 3 months (10 patients). In both groups of the patients, diprospan along with the application of low-intensity infrared laser irradiation reduced the formation of cicatricial tissue which could lead to tracheal stenosis and to the lesion of the external breath function, and considerably reduced the number of patients requiring repeated reconstructive operations.
4. Zhvitiashvili N., Khvitia N., Zhvitiashvili T., Danelia G.
DENTAL DEMYELISATION AND ITS ASSOCIATION WITH CARIES
J. Experimental and Clinical Medicine, 2010, 1, pp. 22-23
Biology Department of Tbilisi State Medical University,
Zugdidi Independent University, Kutaisi Dental Clinic ¹1, Georgia
The dental pulp has been studied during caries. Myelin fibers are damaged and morphologically changed, and shvann cells undergo the cytopathogenic effect.
5. Aliyev O.
Lymphatic link of microcirculation in THE pathogenesis of parodontitis
J. Experimental and Clinical Medicine, 2010, 1, pp. 23-27
Departments of Orthopedic Stomatology and Pathological Physiology,
Azerbaijan Medical University, Baku
The purpose of the present research was to study blood and lymph coagulability, and also the condition of lymphatic drainage of tissues during parodontitis in a rabbit model. Experiments were carried out on 21 “Chinchilla” rabbits of both sexes weighing 2.5-3.0 kg. Solutions of Kalipsolum (8mg/kg) and Dimedrolum (0.15ml/kg) had been introduced intravenously as narcotic agents before the experiment. The research results have shown that modeling of parodontitis in rabbits leads to a rather expressed activation of intravascular coagulation not only in the blood, but also in the lymph against the background of an appreciable oppression of lymphatic drainage of tissues. Comparing our data with the literary data, we drew the conclusion that the activation of intravascular lymph coagulation eventually promotes the impairment of lymphatic drainage of tissues (particularly of parodontium tissues) and plays an important role in the pathogenesis of parodontitis.
6. Feyzullayev M.
IncreaseD lipid peroxidation inhibitS regulation OF erythropoiesis IN patients WITH pancreatic diabetes
J. Experimental and Clinical Medicine, 2010, 1, pp. 27-30
Department of Internal Diseases, AMU, Baku
There were observed 23 insulin-dependent patients with pancreatic diabetes and 20 healthy donors (13 men and 10 women aged 16 to 60). The illness duration varied from 1 month to 20 years. The investigation results showed that during hyperglycemia (20.5mmol/l) an increase of the quantity of lipid peroxidation (POL) was marked in the patients with ID PD in comparison with the control (0.19/0.49st.unit). The results of the analysis showed some increase in the POL concentration which caused damage to the structure of the erythrocytes, and the decrease in the hemoglobin quantity from 140g/l to 128g/l (p<0.05). Blood diffluence resulted in the impairment of erythrocyte differentiation and in the further maturation of the peripheral blood elements. Due to this unusual method of therapy, the compensation of carbohydrate metabolism and normalization of erythropoiesis have been achieved in the patients with ID PD.
7. Safarov A.
BIOCHEMICAL INVESTIGATION OF ORTHODONTIC COMPLICATIONS
J. Experimental and Clinical Medicine, 2010, 1, pp. 30-32
Department of Orthopedic Dentistry, AMU
The study of literature shows that pathological processes resulting from the use of orthopedic constructions prevail in the oral cavity. The quantitative and qualitative content of the oral cavity changes because of the negative action of orthopedic constructions.
8. Aliyev E.
Lymphatic drainage of tissues and blood and lymph coagulability DURING mandible fractures
J. Experimental and Clinical Medicine, 2010, 1, pp.32-36
Department of Oral and Maxillofacial surgery, Department of Pathological Physiology of Azerbaijan Medical University, Baku
The purpose of the present research was to study blood and lymph coagulability, and also lymphatic drainage of tissues during mandible fracture in rabbits. Experiments were carried out on 17 “Chinchilla” rabbits under narcosis. The research results have shown that modeling of a mandible fracture in rabbits leads to the activation of intravascular coagulation not only in the blood, but also in the lymph. The received data comparison has shown that between the activation of blood and lymph coagulability there is an accurate interrelation to what testify unidirectional changes of coagulation indicators (the system of coagulation, anticoagulation and fibrinolysis) both in blood and lymph. Moreover, it is revealed that intravascular activation of blood and lymph coagulability is accompanied by rather expressed oppression of lymphatic drainage of tissues. It all testifies to the necessity of taking into account the lymphatic link of microcirculation in treatment and prophylactic actions for a mandible fracture.
9. Khvitia N., Davarashvili Kh., Zhvitiashvili T., Danelia G.
DENTAL CARIES AND ITS CONNECTION WITH DEMYELINISATION
J. Experimental and Clinical Medicine, 2010, 1, pp. 36-38
Biology Department of Tbilisi State Medical University,
Zugdidi Independent University, Kutaisi Dental Clinic ¹1, Georgia
We used light and electron microscopy to study the dental pulp during caries. The study has shown that some parts of the myelin fibers get damaged, this factor negatively influencing their conductivity. Clinically the process is understood as pain. Changes were also found in the cylinder: there was detected a great number of small vesicles and destructed mitochondria there.
10. Faradjeva N.
THE Efficacy of treatment for chronoc nonspecific lung Diseases by THE methods of non-drug therapy according to follow-up studies
J. Experimental and Clinical Medicine, 2010, 1, pp. 38-41
A.Aliyev State Institute for Advanced Medical Studies, Baku, Azerbaijan
131 patients have been examined: 69 patients with infection-dependent bronchial asthma (IDBA); 37 – with moderately severe, 32 - with severe and persistent illness; 63 patients – with chronic bronchitis (CB); 31 patients with chronic purulent non-obstructive bronchitis (CPNOB), and 32 - with chronic purulent obstructive bronchitis (CPOB).
67 patients of the basic group (35 with IDBA and 32 with CB) received the combination of medicamentous therapy (MT), halotherapy (HT) and endobronchial exposure (EBE) with sessions of various durations, and a general course of treatment depending on the form and severity of the clinical course of the disease. The control consisted of 65 patients receiving only MT.
The analysis of follow-up studies has shown a considerable clinical effect in both nozological groups under the combination of MT and HT/EBE.
11. Zeynalov A., MekhTiyev U., Masimov J., Humbatova A.
A Comparative analysis of THE main risk factors OF coronary heart disease in THE Baku male POPULATION aged 15-18 and 20-59
J. Experimental and Clinical Medicine, 2010, 1, pp.41-45
Therapy Department and Cardiology Department, A.Aliyev State Institute for Advanced Medical Studies, Ministry of Public Health of Azerbaijan Republic, Baku
Data concerning the prevalence of the main factors of coronary heart disease (CHD) among the Baku males aged 20 to 59 (1996) and 15 to 18 (2008-2009) were obtained. There were applied strictly standardized methods of examination and criteria of their evaluation recommended by the WHO for epidemyological researches. Statistical treatment was conducted in accordance with the current requirements for analyzing parametric and nonparametric data.
It was established that CHD risk factors promoting formation of the metabolic syndrome prevail among the Baku male population aged 20 to 59. Metabolic syndrome risk factors were also observed among the males aged 15 to 18. We can consider as positive the fact that more than half of males in Baku aged 15 to 18 go in for sports and have low-rate smoking behavior. Every tenth of 15-18 years old examined males had hypertrophy of one or both ventricles. The latter pathology was registered 10 and more times as often as compared with its isolated forms.
A conclusion was drawn about the necessity of development of the National program aiming at CHD risk factors prevention, starting from school-age persons.
12. Safaraliyeva A.
Prevalence of CHD risk factors separately and in various combinations among the Baku population AGED over 20
J. Experimental and Clinical Medicine, 2010, 1, pp.45-49
Mir Kasimov Republican Clinical Hospital,
A.Aliyev State Institute for Advanced Medical Studies, Baku, Azerbaijan
A representative sampling of unorganized male and female inhabitants of Baku aged over 20 has been studied. Strict standardized methods of investigation and evaluation were applied when coronary disease and its main risk factors were detected. The studied risk factors were hypertension, body-weight index, strenuous physical activity, smoking, alcohol drinking, hypercholesterolemia, hypertriglyceridemia or hypo-cholesterin of high-density lipoproteins. Statistic handling of the received results has been conducted taking into consideration modern requirements.
The received results indicated that the number of males and females aged over 20 being studied upon the risk factors was approximately 100% in the absence and presence of coronary disease. In the absence and presence of coronary disease risk factors were assigned as a reason for the metabolic syndrome formation. This is a negative prognostic indicator which may cause a subsequent development of the disease and mortality for the reason of cardiovascular pathology.
As a negative result, we can state the fact that the majority of both genders had combined four risk factors. The conclusion was drawn that the most acceptable strategy for the population over 20 is mass prophylaxis.
13. Zamanov N.
Spread of the risk factors of coronary heart disease AMONG the patients with rheumatoid arthritis
J. Experimental and Clinical Medicine, 2010, 1, pp. 49-53
Department of Internal Diseases and Reanimatology ¹1 of AMU, Baku
125 patients with rheumatoid arthritis (RA) were involved in the investigation. Among the classical risk factors of coronary heart disease (CHD) smoking was not marked among the woman, and among the men has made 90%. Arterial hypertension was found in 44.4% of the patients with RA.
Serious changes were determined in the lipid-protein blood spectrum. The risk factors of CHD are marked basically in patients with seropositive form of RA. A positive correlative communication was detected between such CHD risk factors as anemia, arterial hypertension, C-reactive protein level. CHD risk factors in a greater degree were increased in the patients whose RA continued more than 5 years.
The level of fibrinogen depends more on the duration of the disease, and the level of C-reactive protein – on the degree of RA activity.
14. Davarashvili Kh., Zhvitiashvili T., Khvitia N., Danelia G.
TO THE PROBLEM OF DEMYELINISATION IN THE DENTAL PULP
J. Experimental and Clinical Medicine, 2010, 1, pp. 53-55
Tbilisi State Medical University, Zugdidi Independent University,
Kutaisi Dental Clinic ¹1, Georgia
A great attention is paid to the peripheral nervous system when the dental pulp is studied. For this study we have used light and electron microscopy. Demyelinisation is connected with the cytopathogenic effect in the Shvann cells. There should be mentioned the occurrence of myelin depolarization.