J.EXPERIMENTAL & CLINICAL MEDICINE
2010, ¹ 3
1. Bakuridze A., Yakobadze B., Shavdia N., Mikeladze N.
THE ACTION OF BIFLAZIM ON THE HYPOPHYSEAL-GONADAL AND HYPOPHYSEAL-ADRENAL SYSTEMS DURING NON-GONORRHEAL URETHRITIS
J. Experimental and Clinical Medicine, 2010, 3, pp.9-12
Medical Department, Batumi Sh. Rustaveli State University, Georgia
To investigate the efficacy of thrombin-Biflazim, the preparation was given per os after meals to 34 patients with non-specific urethritis complicated with scrotal inflammation. Biflazim was effective to resolve gonadal inflammation and pathospermia. Biflazim didn’t affect prolactemia, reduced follitropin and luteotropin to the normal level; increased the level of testosterone and estradiol in the blood, regulated the function of gluco- and mineral cortical hormones.
2. LATSABIDZE I.
MORPHOLOGICAL CHANGES DEVELOPED IN RAT PANCREATIC ISLETS DURING ALLOXAN DIABETES AND AFTER THE EFFECT OF PLAFERON
J. Experimental and Clinical Medicine, 2010, 3, pp.12-15
A.Natishvili Institute of Morphology, Tbilisi, Georgia
We have studied sclerotic changes developed in rat pancreatic islets at different stages of alloxan diabetes and after treatment with Plaferon. At the later term of alloxan diabetes, the infiltration of islets with fibroblasts, lymphocytes, plasmocytes, and collagen fibers takes place. In animals treated with Plaferon the activation of macrophages occurs and at the same time collagen lysis is marked. It facilitates the movement of insular granules towards the capillary, which is revealing of the compensatory-adaptation process.
3. Guliyev N., Makashvili L., Kobeshavidze D.
Possible criteria for early diagnosis of endometrial hyperplastic processes (EHP)
J. Experimental and Clinical Medicine, 2010, 3, pp.15-20
Institute of Obstetrics and Gynecology, Azerbaijan, Baku
Maternity Home “IMEDIS CLINICA”, Tbilisi, Georgia
Our aim was to develop a systematic approach to early diagnosis for correction of EHP (150 women, in the early reproductive period were 64 (42.7%), in the late reproductive - 86 (57.3%)). Disease duration in 54.8% of cases ranged from 3 months to 1 year.
The patients were divided into 3 groups: I group - 70 patients (46.7%) with glandular and glandular-cystic hyperplasia of the endometrium; II group - 65 (43.3%) - with endometrial polyp; III group - 15 (10%) - atypical endometrial hyperplasia (clinical, cyto- and histological techniques, ultrasound and hysteroscopy were used). Based on the results, the following algorithm of examination was made: clinical-anamnestic examination, evaluation of patients’ complaints, the overall clinical and biochemical analysis of the blood (Tumor marker CA-125, CA 19-9), cytological and histological examination, pelvic echography. A systematic approach to the correction of endometrial hyperplastic processes will be developed.
4. Porchkhidze L., Khvitia N., Zurabashvili S., Zhvitiashvili T.,
Danelia G., Davarashvili Kh.
ENDOTHELIUM IN PARODONTITIS AGAINST THE BACKGROUND OF CARDIOISCHEMIA
J. Experimental and Clinical Medicine, 2010, 3, pp.20-24
Department of Biology, TSU, Department of Stomatology, ZIU, Georgia
A study of the endothelium against the background of ischemia showed that both diseases – parodontitis and cardioischemia are sinergetic. These diseases are widely spread pathologies. The treatment of these diseases is very difficult as it requires the medicine which injures none of them.
5. Shengelia M., Chikvaidze E., Kiladze M., Sanikidze T., Gogebashvili N.
EPR study of bile stones in menopausal women
J. Experimental and Clinical Medicine, 2010, 3, pp.24-27
Tbilisi State Medical University,
I.Javakhishvili Tbilisi State University, Georgia
The aim of the study was to establish bile stones content in menopausal women by EPR method. The bile stones of 30 women aged 52.4±9.7 years were studied (2 women with surgical menopause (33-35 year); 19 women with menopause (39-56 year); 9 women in postmenopause (59-79 years)). Stone EPR spectrum was registered on the EPR spectrometer ESR-V. In EPR specter of the stones the intensive signal of oxidized bilirubin (g=2.003, DH=1.0mmTl) was revealed; statistically important difference between the intensity of this signals in the stones of the patients of different age groups was not revealed. In EPR specter of some bile stones 6-component EPR signal of Mn2+ ions was registered.
It was concluded that the deficiency of estrogens in menopausal women induces decrease in the antioxidant defense mechanism of the patient’s body and thus, in the condition of oxidative stress (connected with different endogenous and exogenous factors), promotes the oxidation of bilirubin and bile stone formation.
6. Geydarova K., ShamKhalova I., Makashvili L.,
CHIGLADZE P., KOBESHAVIDZE D.
Dopplerometric description of the uterOplacentaL-fetal circulation in pregnancies with fetOplacentaL dYsfunction
J. Experimental and Clinical Medicine, 2010, 3, pp.27-32
Scientific Research Institute of Obstetrics and Gynecology, Baku, Azerbaijan
Maternaty Home “Imedis Klinika”, Georgia, Tbilisi
The major aim of the investigation was to study the uteroplacental circulation specificity in pregnant women with fetoplacental dysfunction and early pregnancy loss in anamnesis. Equally important was the determination of the fetoplacental circulation in pregnancy loss.
Doppler velocimetry was performed in 122 pregnancies: in the basic group n=82 and in the control group n=40. The age of the women was between 22-33 years.
In 51 (62,2 %) women with I-II level arterial circulation dysfunction systolic ratio was increased by 7.7% as compared to the control group, early diastolic ratio – by 17.3 % and medium reverse flow – by 6.4%.
Common changes in venous circulation of the women with fetoplacental failure increased systolic flow during a decrease in the systolic period in the atriums. The highest systolic flow was determined in 21.9% of the pregnant patients without disturbances in the arterial part of the fetoplacental system. Doppler index was lower than the control group or equal to it.
During hemodinamic dysfunction in the arterial part of the fetoplacental system, an index of resistance progressively increased in the venous flow and reached the maximal level in 15,7% of the women.
Doppler velocimetry index of the inferior vena cava changes simultaneously with the increase in arterial flow dysfunction and severity level of fetal condition.
7. BAKURIDZE A., YAKOBADZE B., SHAVDIA N., MIKELADZE N.
Treatment of chronic prostatitis in the light of concomitant cardiovascular disease
J. Experimental and Clinical Medicine, 2010, 3, pp.32-36
Batumi Sh. Rustaveli State University, Georgia
Given the favorable impact of á-adrenoblockers on the prostate function in order to improve blood cirulation in the organ, the preparation “Kardura” (2 mg once per day) was prescribed to 20 patients with chronic elderly prostatitis, associated cardiovascular problems and disuretic disorders. In the complex treatment of uretroprostatitis, the activity of the immune system increased, indicators of the pituitary-gonadal system became settled, which makes it possible to recommend Kardura for the treatment of prostatitis in the elderly.
8. Ismailova M., Shamkhalova I., Makashvili L., bajelidze i.
Up–TO-daTE correction methods foR Climacteric SyndRome
J. Experimental and Clinical Medicine, 2010, 3, pp.36-40
G.Gasymova Maternity Hospital ¹ 1, Baku, Azerbaijan
Maternaty Home “Imedis klinika”, Tbilisi, Georgia
Pathological conditions caused by the age-specific changes accompanied by hormonal reconstruction are considered in the article. The climacteric syndrome in combination with metabolic disorders requires obligatory correction not only via hormonotherapy, but using exchange processes as well. The literary data of different researches devoted to the study of the efficiency of the substitutive hormonotherapy (SHT) implementation with climacteric syndrome are described in this article.
Numerous researches have proved that the use of substitutive hormonal therapy in combination with different analogues of sexual steroid hormones and medicines improves exchange processes in the basic procedure of menopause prophylaxis and treatment, thus improving living activities of women at this age-specific period.
Presently, various phytotherapeutic medicines are widely introduced into practice and implemented along with SHT.
9.Arabuli M., Khetsuriani R., Shukakidze A., Topuria D., Tchlikadze N., Kirvalidze I.
AGE-RELATED CHANGES OF CHOLESTEROL INDEX IN ERYTHROCYTE MEMBRANE AND THEIR INFLUENCE ON DEFORMABILITY OF ERYTHROCYTES
J. Experimental and Clinical Medicine, 2010, 3, pp.40-43
Tbilisi State Medical University, Georgia
The research objective was to study age-related changes of the index of erythrocyte membrane cholesterol and their influence on the deformability of erythrocytes. Studies have been performed in 3 age groups: newborns (umbilical cord blood), adults (22-30 years old) and elderly people (75-89 years old). Based on the results, we can assume that erythrocyte deformability depends on the cholesterol index of the erythrocyte membrane, and with less cholesterol the deformability of erythrocytes increases. Erythrocyte deformability in newborns is high, which is due to the low content of cholesterol in their membranes. Deformability is higher also in the elderly, because in their membranes cholesterol is less then in the membranes of adults.
10. Davarashvili Kh., khvitia n., zhvitiashvili T., Danelia G.
NORMAL DENTAL PULP
J. Experimental and Clinical Medicine, 2010, 3, pp.43-45
Department of Biological Medicine, Tbilisi State Medicl University, Georgia
Normal dental pulp has been studied with the help of light and electron microscopy. The structure of the pulpal innervation and vascularization were investigated. A great deal of attention was also paid to the pulp structure.
11. Chachibaia T., Aptsiauri E., Bulia I., Aleksidze A., Aleksidze I., Gabashvili T.
PILOT STUDY OF PRIMARY PREVENTION AND SCREENING ON ENVIRONMENTAL FACTORS IN PATHOGENESIS OF SJOGREN’S SYNDROME ASSOCIATED SALIVARY AND LACRIMAL GLAND LESIONS
J. Experimental and Clinical Medicine, 2010, 3, pp.45-50
Georgian Sjogren Association; Rare Diseases Alliance; O.Gudushauri National Medical Centre, Ophthalmology department; Ophthalmological Clinic “Optimed”, Tbilisi, Georgia
Sjogren’s syndrome is chronic autoimmune inflammatory rheumatic disease, attacks exocrine, i.e. salivary and lachrymal glands, causing complication such as dryness of mouth and eye in affected individuals. Mainly is diagnosed among women population in 90% of cases. Sjogren’s syndrome affects mainly women in their 40-50s, though younger age onset is also characteristic. Later disease is progressed and other organs are involved as well. There is substantial risk of development of malignant lymphomas and characterized by 44-fold increased risk compared to general population.
Environmental factors are thought to trigger inflammation in individuals with a genetic redisposition for the disease.
Primary prevention of Sjogren’s syndrome is directed to increase awareness of harmful environmental conditions, which may be avoidable, also to educate recognition of early warning symptoms of this condition. Timely diagnosed lesion is better treatable and late onset complications are also preventable.
The aim of “Georgian Sjogren Association” is to perform screening and provide prevention of Sjogren’s syndrome in Georgia. In cooperation with the “Alliance for Rare Diseases of Georgia” we apply our joint efforts in the prevention of this disease among women population in Georgia.
With the support and assistance from the specialized ophthalmologic clinics we plan to perform primary prevention and screening (pilot study) of susceptible individuals on 12 June 2010 during Rustavi Women’s Health Fair - Celebrating Healthy Women. Event was organized by Peace Corps Georgia Volunteers and Rustavi NGO Young Initiators.
Objectives. The goal of primary prevention is to avoid the development of cancer by reducing or eliminating exposure to cancer-causing factors.
Primary (1o) prevention at the population, as well at individual i.e. patient-doctor communication level is to avoid initiation of pSS by means of declining impact of harmful environmental factors, such as smoking, air conditioning, etc. Activities for primary prevention were undertaken, particularly:
I. Short presentation on the following topics: Age related hormonal changes, environmental factors and genetic predisposition in triggering primary Sjogren’s syndrome. Environmental factors in pathogenesis of Sjogren ’s syndrome associated salivary and lachrymal gland lesions, primary prevention. Recommendations and measures on primary prevention. Role of stress in the development of autoimmune diseases. Stress management techniques. What is the benefit of prevention of autoimmune diseases for the women in their peri/post menopausal periods of life.
II. Training - Primary prevention for Sjogren’s syndrome – recognition of the causes and outcomes of dry eye and mouth symptoms.
III. Health consulting - Examination of dry eye and dry mouth complaints in susceptible population. Individual and population level primary prevention and screening (pilot study).
Conclusion: Based on the results of pilot study for the further study was chosen individual-level, i.e. secondary screening and prevention at the patient-physician level versus population-level approach.