2010, ¹ 4



1. B. Zurashvili,  M. Giorgobiani

Ecological problems Caused by Global Warming and

health Risks of population

J. Experimental and Clinical Medicine, 2010, 4, pp.14-17


Tbilisi State Medical University, Faculty of  Public Health,  G. Natadze Scientific-Research Institute of Sanitary and Hygiene, Georgia


Climate change is a change in the statistical distribution of weather over periods of time that range from decades to millions of years. The Earths climate has changed throughout history. From glacial periods (or “ice ages”) where ice covered significant portions of the Earth to interglacial periods where ice retreated to the poles or melted entirely – the climate has continuously changed.

Factors that can shape climate are climate forcing. These include such processes as variations in solar radiation, deviations in the Earths orbit, mountain-building and continental drift, and changes in greenhouse gas concentrations. Levels of carbon dioxide, methane and nitrous oxide gases are rising, mainly as a result of human activities. Carbon dioxide is being dumped in the atmosphere at an alarming rate. Since the Industrial Revolution, humans have been pumping out huge quantities of carbon dioxide, raising carbon dioxide concentrations by 30% and average global temperature appears to have risen between 10C and 20C.

Obviously, climate has a big influence on plants and animals in the natural environment, on oceans, and on human activities, such as agriculture, water supplies, and heating and cooling. The effects of climate change depend upon how much change there is, how fast it occurs, and how easily the world can adapt to the new conditions.

These problems are mortified and needs them to be solved. This needs different specified professional relations for example the scientists which are working for this medical sphere. G. Natadze Scientific-Research Institute of Sanitary and Hygiene and on its base was created scientific practice center for global warming and for the health of the population. The target of these two is to avoid the changing of the climate and the risks, treatment and rehabilitation of the  deceases  which can be created.



2. T. Shishniashvili, N. Suladze

Atmosphare air feature indicators and their influence on the toot  hard tissues mineralization

J. Experimental and Clinical Medicine, 2010, 4, pp.17-21


Tbilisi State Medical University, department of children and adults stomatology and stomatological desease prophylaxis, Georgia


The influence of quality indicators of atmospheric air on junior children’s dental status was studied by us on 3-4 years old 350 children examined by standard methods provided by Health Care Organizations (tooth caries spread, intensity and non-caries damages).

According to our study high indicator of tooth caries (averagely 89.9%) was manifested in all districts of city of Tbilisi and several occasions (8 in total) of tooth non-caries damages, especially hyperplasia that to our opinion, is not depended on coefficient of pollution of atmospheric air. Simultaneously, ecological indicators make important influence on intensity of tooth caries and it is higher in the districts where the level of pollution of atmospheric air exceeds by several times to the limit established by international standards than in ecologically more reasonable districts    and respectively amounts to 6.0 and 3.9.

As a result of data analysis we can make conclusion that high composition of ecotoxint in the atmospheric air makes significant influence not only on organs and systems of human organism, but represents serious risk-factors of dental pathologies generation and development too. 


3. Arziani B.A., Lekishvili G.N., Chikhladze Ts.K., Nadirashvili M.D.

Biodegradation of Egsogenous Phenol in Organism of Rat

J. Experimental and Clinical Medicine, 2010, 4, pp.21-24


Tbilisi State Medical University, Georgia


Biodegradation process of 1-6-14C-phenol in organism of rat has been studied. It was established that metabolism of its molecule proceeds at high rates at intraperitoneal injection of the aforementioned xenobiotic. Extent of degradation of the aromatic ring was also high. Major contribution to radioactivity has to be attributed to the conjugation product of phenol with glucuronic acid. Phenol sulfate as an outcome of biotransformation was not found among conversion products. Part of the injected phenol is excreted untransformed.




4. LobZHanidze N.,  Chavchanidze N.,  Giorgobiani T.,  Rusieshvili L.,  

KOurdadze E.

Toxicological Issues Connected with  Substances Containing Lead

J. Experimental and Clinical Medicine, 2010, 4, pp.24-27


Direction of Clinical Toxicology, Department of Critical Medicine, TSMU, Tbilisi, Georgia


The harmful effects of lead intoxication were well-known as early as in the 1940 years. Nowadays,  lead is still the leading substance among those causing industrial poisoning. This article reveals and discusses a clinical case of intoxication by  lead. Several recommendations for prevention and treatment of such cases are also provided.



5. Mchedlishvili T., Gelovani D., Imnadze P., Mchedlishvili I.

The dynamics of incidence of Salmonellosis  in Georgia

J. Experimental and Clinical Medicine, 2010, 4, pp.27-29


Department of public health of Tbilisi State Medical University,

National Center For Disease Control and Public Health ,Tbilisi, Georgia


We have studied the dinamics of incidence of Salmonellosis in Georgia for years 1960-2009. Before 1973 incidence rate was relatively low which subsequently had a significant increase and it continued till 1988. Afterwards increase turned into decrease and in 21th century incidence rate was determined as 6,2±1,05 per 100 thousand population. The changes in the dynamics of incidence rate of Salmonellosis is characterised by the changes of etiological structure of the disease. Earlier the disease was almost always caused  by  S. typfhimurium, although currently the cause of the infection is S. enteritidis. As a result chicken meat, eggs and products made from them have a bigger role in the distribution of the disease.





J. Experimental and Clinical Medicine, 2010, 4, pp.29-31


Tbilisi State Medical University, Georgia


Aim of the study was to investigate the etiological structure of vaginitis dynamic 2006-2009. Vaginal flora in 250 females during the inflammatory vaginitis was investigate by bacteriological analysis.

By the rate of excretion, staphylococci came the first, the second was T. vaginalis, Ñ albicans deing the third.

one third of the microorganisms was detected in a form of monocultures, two-thirds as associations, the most frequent combinacions amoug which were: S.epidermidis+T.vaginalis, T.vaginalis+C.albicans, T.vaginalias+E.coli. Among the combinacions were manifested in afrom veginites of mix-infectious etiology caused by the presence of three or more symbionts.





J. Experimental and Clinical Medicine, 2010, 4, pp.31-34


Tbilisi State Medical University, Georgia


By means of sociological inspection and an expert estimation stomatologic desease among 3000 respondents of frontier areas of Georgia has been studied. By virtue of distinction and features risk-factors, heavy social and economic situation in country and absence of specialized (stomatologic) social programs and the insurance, the noted population, especially in zones of the conflict, is deprived the qualitative and accessible stomatologic help.

In prevention a stomatologic pathology it is important to involve various mechanisms of medical and social aid. In particular, carrying out of the primary stomatologic help within the framework of humanitarian actions for inhabitants of frontier areas can partially solve this problem. 


8. M.Tsitsagi,  G.Kvartskhava,  M.Chkhaidze,  I.Jinikashvili, M.Khachidze

Supercritical Co2 Extraction Of Food Colorants From

Vegetable Matrices

J. Experimental and Clinical Medicine, 2010, 4, pp.34-38


Petre Melikishvili Institute of Physical and Organic Chemistry, Tbilisi, Georgia


Natural food colorants are favored over the synthetics in recent years. Productions of synthetic dyes is cheaper, has bright, vivid colors and are stable, but natural ones considered as healthy products. The most abundant natural food colorants are anthocyanins, b-carotene and lycopene. Grape skin, mandarine, orange and persimmon peels, tomato paste waste are good source of natural colorants in Georgia. Supercritical fluid extraction is advanced separation technique for receiving food colorants.



9. Kavtaradze N., Alavidze A., Mikadze I., Uridia R., Dolidze A.

Rational use of plant raw materials for obtaining medical means

J. Experimental and Clinical Medicine, 2010, 4, pp.38-41


Laboratory of chemical ecology problems, P. Melikishvili Institute of

Physical and Organic Chemistry,  Tbilisi, Georgia


Getting compounds on the basis of plant metabolites and their derivatives isolated from local plant raw materials (groundsel, coniferous plants, alpine sorrel, grape stones) makes possible to obtain and use new natural hydrocarbon, anthraquinone and alkaloid block-syntones. It gives an opportunity to receive variety of interesting biologically active substances. Obtaining of new medical preparations on the basis of them is possible.


10. Bokuchava N.V., bibileishvili D.V., Berdzenishvili I.G., Ebanoidze L.O.


J. Experimental and Clinical Medicine, 2010, 4, pp.41-44


The aim of this work is the use of natural resources of Georgia - mud (pelloidy), bentonite clay, mineral water, alcoholic and oil extracts of medicinal plants for cosmetic purposes. Based on these ingredients for the first time to obtain new formulations of cosmetics - cream-mask, toothpastes and shampoos.


11. Karalashvili I., Klarjeishvili N., Jabishvili N., Urotadze S., Javashvili I.

Study of antimicrobian properties of iron polyphosphate and perspective of its usage

J. Experimental and Clinical Medicine, 2010, 4, pp.44-47


Petre Meliqishvili Institute of  Physical and Organic Chemistry, Georgia, Tbilisi


Antimicrobian and viral properties of inorganic polymer compound’s of  iron polyphosphate have been studied. In order to detect bactlericidal and viral properties, there was  studied an enfluens of deferent concentation of iron poliphosphate solution on viruses and microorganizms.According to results was determined, that solution of iron poliphosphate is carachterized with antimicrobian property and dezodoration ability. Iron poliphosphate is ecologicaly harmless, contains iron and phosphate ions and represents pink solution with no smell.


12. Antelava N., Okujava M., Pachkoria K., Ghonghadze  M.

Biologic Activity of Grape Products

J. Experimental and Clinical Medicine, 2010, 4, pp.47-50


Department of Pharmacology and Pharmacotherapy, Tbilisi State Medical University, Georgia


In the article is discussed antioxidant role of grape polyphenolic compounds in prevention of free radical related diseases. The review of the literature data of red wine polyphenols protector activity on molecular, submolecular levels and whole human body depending on wine brand, preparation technology and volume of consumption was performed.

According to reviewed literature polyphenolic extracts and separate compounds (resveratrol) of wines are  used as medicines in clinical practice for prevention of free radical diseases, as well as in cosmetology and spa therapy.

As Georgia is rich with grapes, further investigation of  biological activity of  different brands of wines, wine extracts, grape compounds and alcohol free beverages is desirable.


13. Tsitsishvili V., Dolaberidze N., Alelishvili M., Tsintskaladze G., Mirdzveli N., Nizharadze M.


J. Experimental and Clinical Medicine, 2010, 4, pp.50-53


P.Melikishvili Institute of Physical and Organic Chemistry, Tbilisi, Georgia


Natural and synthetic zeolites are used in medicine as sorbents and ion exchangers in different forms, in the US, Japan and several other countries “liquid zeolites” are marketed mainly, Megamin – “tribomechanically activated” clinoptilolite-containing preparation is popular in Europe, China prefers traditional powders, in Russia original Litovit in many modifications has been developed. Georgia is rich by natural zeolites (clinoptilolite, phillipsite, etc.), their physical and chemical properties are well studied, showing possibility of application for medical uses. 


14. Tsintskaladze G., Gersamia M.*, Tsitsishvili V., Ebralidze K., Burjanadze M.


J. Experimental and Clinical Medicine, 2010, 4, pp.53-56


Petre Melikishvili Institute of Physical and Organic Chemistry, Tbilisi

*Chear of  TSMU Surgical Dentistry and Maxillofacial Surgery, Tbilisi 4th Clinical Hospital, Georgia


Clinoptilolite, natural zeolits located in Georgia, enriched by phosphorus and calcium has been studied. Investigations on the rabbits shows possibility of use of this materials in clinical practice for treatment of osteomelite, odontogenic cist, for completion of defects of jaw bones.



15. I. Beshkenadze, M. Gogaladze,  N. Zhorzholiani, N. Osipova, I. Lomtadze,



J. Experimental and Clinical Medicine, 2010, 4, pp.56-59


P.Melikishvili Institute of Physical and Organic Chemistry; Tbilisi State Medical Universitety, Tbilisi, Georgia


Proceeding from the above stated have we synthesized the chelate type compounds which contain glutaminic acid and minerals. Synthesized compounds were identified and a series of physical and chemical properties (melting, solubility in various solvents, nature of metal-ligand bond) were defined. Powder form biologically active additive was prepared on the base of the synthesized compounds. It can be used as dietary supplement and it can provide for: Nutrition  rationalization (compensation of mineral deficit); Psycho stimulation effect and heightening of capacity for work, improvement of mood    and sleep; Decrease of ration caloric content, decrease of body weight; Satisfaction of physiological demands of a man for food; Restoration of reduced immune system in men.






J. Experimental and Clinical Medicine, 2010, 4, pp.59-62


Tbilisi Balneology Resort- Scientific/Practical Center Of Health Resort Managing, Physiotherapy, Rehabilitation And Medical Tourism Of Georgia; TSMU; Georgia


Camelyn is biology active preparate, produced by Georgian famous surgery Benediqt Maglakelidze in the middle of XX century,from special, ecology clean, Kolkhis honey.

After a lot of clinical and experimental trials, was determined, that Camelyn has immunomodulate, antioxidant and antiinflamatory action.

As osteoarthritis and osteochondrosis are most common medical problems in the world. It’s the number one cause of disability in America. Nearly 40 million Americans have some forms of arthritis.Althought acure has yet to be found, effective treatments and other strategies are readily available.

That’s why, we decided to consider the need of usage of the ultraphonophoresis of “Cameyn M3” (20 patients) and electrophoresis of  “Camelyn Ml” (20 patients), for treatment of some forms of osteoarthritis and osteochondrosis.

As we have managed high therapeutic effect and improving of the quality of life in both groups, we recommend to use these new effective methods widly in clinical, physical medicine and rehabilitation.



17. T.Tchumburidze, Z.Bendeliani, N.Nemsitsveridze, A.Isakadze, T.Zarkua


J. Experimental and Clinical Medicine, 2010, 4, pp.62-64


Tbilisi State Medical University, Department of Social and Clinical Pharmacy


Epiedemiological data reflects significantly increased percentage of population suffering by allergic diseases, Especially it concerns to allergic reactions influenced by industrial and biological factors.

Allergic reaction plays leading role in phatogenesis of dermatitis and mechanism of such reactions are based on release of histamine and serotonin. Development of drug with both antihistamine and antiserotonine activity was the goal of this study. Drugs with close chemical structure and pharmacological activity where selected from derivates of quinuclidin carbinols. This differences in pharmacological activity of different compounds makes Dualler-G a new antiallergic drug with antihistamine and antiserotonine activity. The goal of the study was clinical trail of Dualler-G in patients with dermatitis. Obtained data suggests that Dualler-G shows high effectiveness in treatment of different types of dermatozis.

The effect of Duralles-G, an original antiallergic drug, was evaluated in patients displaying different kinds of dermatozis (urticarea, neirodermatitis, lichen rubber planus, eczema).  A total of 22 patients diagnosed with dermatitis were randomized to receive in an open fashion 60 mg of Dualler-G per day, for 2 weeks. Efficacy was assessed according to the global improvement rating of elements on skin or itching as symptoms or signs. Patients treating with Dualler-G (cases of urticarea, neirodermitis and lichen rubber planus) had superior improvements in there symptoms (elements on skin and itching) compared to controls overall across the 2 week trial, bat not in cases of eczema. However, evening cases of eczema level of eosinophils was reduced and severity of symptoms as well. Clinical course of patients treated with Dualler-G  tended to be significantly better then the patients treated with other antiallergic prep rats, and the symptoms were significantly correlated in the dualler-G treated group.

These Data suggest that Dualler-G provide direct efficacy on the symptoms (skin elements and itching) in patients with different kinds of dermatozis, and its mach higher  other drugs.


18. Tabidze G., Tsibadze T., Kobaladze N., CHkuaseli N.

Metabolic effects of Nebivolol in patients with type-2 Diabetes

J. Experimental and Clinical Medicine, 2010, 4, pp.64-68


Georgian Academy Preventive Medicne; M.Tsinamdgzvrishvili Scientific-Research Institute for Cardiology; Tbilisi Iv. Javakhishvili State University, Georgia


A novel super selective b-blocker with NO-modulating activity nebivolol used as an antihypertensive drug in patients with non-insulin-dependent diabetes exerted good hypotensive effect which was not associated with negative changes of the lipid spectrum.




J. Experimental and Clinical Medicine, 2010, 4, pp.68-71


TSMU, Department of Propedeutics, Tbilisi, Georgia


The purpose of the research was revealing the peculiarities of course of  community acquired  pneumonia. During 2007-2010 y  427 patients were studied. The main group of the patients were dated from III class of  PORT- scale. Were revealed, that the number of  community acquired  pneumonia cases has increased for years. In 2008 was diagnosed 15,98% from all admitted patients. The number of both sided pneumonia was 17,36%. In  2009 25,82% and 40,76%. In 2010, during three month 40,34% and 55,20%. Was determined increase of complications of community acquired  pneumonia also, especially by the pleurisy. By  the bacteriological investigations was shown,  that the spectrum of pathogenic organisms was not changed in last ten years. These findings are shown in statistically trustworthy studies also.


20. A. TSibadze2,  L. Basiladze1,  T.  Kavtaradze,  T. GotSiridze2,  L. KhutSishvili2

Influence of coronary bypass surgery on autonomic regulatory mechanisms of Heart rhythm

J. Experimental and Clinical Medicine, 2010, 4, pp.71-73


1G..Chapidze Emergency Center of Cardiology. Department of Cardiac Surgery;

2Tbilisi State Medical University, Departament of Functional Morphology, Tbilisi, Georgia.


It’s been concluded that decrease of heart rhythm variability in patients with chronic heart failure is conditioned by raised activity of the highest vegetatory regulation centers. In early post CABG period this activity owing to increased parasympathetic stimulation is getting raised. Such  alteration indicates postoperative cardiac rhythm balance changes and possibility of  complications.

Monitoring of the patients by above mentioned values is advisable to avoid postoperative complications.


21. Katamadze N., Beridze S.

Arterial hypertension at women

J. Experimental and Clinical Medicine, 2010, 4, pp.73-77


TSMU Department of Internal Medicine ¹2, Tbilisi, Georgia;

RSU Faculty of Public Health, Batumi, Georgia


Arterial hypertension, as one of the important cardiovascular risk-factors, still remains one of the most important medical subjects, including women. Only small percentage of patients knows that they have hypertension, and even less number of people are treated appropriately. Healthy lifestyle is the most important for primary and secondary prevention of cardio vascular diseases. Desired effect is often reached with complex medical treatment. Despite of women’s systematic involvement in clinical trials, it still remains difficult to formulate specialized recommendations, because the percentage number of woman is still not represent table.  Better knowledge of the pathological mechanisms leading the postmenopausal women to hypertension provides to elaborate more adjusting and rational treatment. 


22. Isakadze  A., Shurgaia  Sh., Burkadze  N., Noniashvili  M.

Dislipidaemia   in  a  family  physician  practice

J. Experimental and Clinical Medicine, 2010, 4, pp.77-80


The Science Academy of  Preventive  Medicine  of  Georgia, Tbilisi


Dislipidemia  is  one of  the most important risk factors of  cardiovascular diseases. The  priority  of  prevention of cardiovascular diseases is to reduce the number of  patients with high cholesterol levels. A  way  of  solving  this  task is to enhance  the  patients  awareness  of  the  target  levels  of  lipid  metabolic parameters and  the  necessity of  their  regular monitoring. The  awareness of the  level of  cholesterol and its atherogenic fractions was assessed in a group of 222 patients who  considered themselves apparently healthy. In these patients, the parameters of lipid and carbohydrate metabolism were determined  and  blood  pressures  and anthropometric indices  were  measured. The study group demonstrated high prevalence of dyslipidemia and metabolic syndrome  and low awareness of  the values of  the lipid spectrum, which generates the necessity of  performing futher studies to develop goal-oriented preventive programs, including educational ones.



23. Dolidze I.

Role of Rehabilitation and Valeology in the Health Management System

J. Experimental and Clinical Medicine, 2010, 4, pp.80-83


Tbilisi  State  Medical  University, Faculty of Physical Medicine and Rehabilitation, Georgia


The development  of  health Management System requires integrated collaboration of  scientists from various fields, including  of  rehabilitologists,  valeologiests, with participation of pathologists and sanologists. The First  problem  is  organization of the collaboration between the scientists from deferent fields, who are working on the problematic issues of healthy and ill people. Secondly, with integrated method of approach have to be worked out criterions of scientific  knowledge systems, and on the bases of these, should be determined the special purpose and development strategy of field.


24. N.Burkadze, A.Isakadze, Sh. Shurgaia

Correction non-modifiable risk-faktors in adults

J. Experimental and Clinical Medicine, 2010, 4, pp.83-85


The Science Academy of Preventive Medicine, Tbilisi, Georgia


 Article presents:

1. Identification of arterial hypertension, overweight, low physical activity, smoking, alcohol and salt over usage, psycho-emotional stress and drug addiction in the same populations.

2. Stratification of examined populations to risk-groups (low, middle and high risk groups).

3. Development and implementation of differentiated preventive intervention programs for middle and high risk groups.

4. Development of measures for healthy lifestyle principles promotion (development and distribution of educational literature taking into consideration specific features of the population, trainings with active participation of adults, information and involvement of mass media).

5. Dynamic supervision of the whole population (with examination of focus groups) and implementing preventive activities.

6. Assessment of regular dynamic supervision and active intervention significance for risk-factor correction (repetitive testing of population, examination to detect risk factor frequency).

7. Development of the model for youth education on healthy lifestyle principles and its recommendation for implementation in public health





J. Experimental and Clinical Medicine, 2010, 4, pp.85-89


Ilia Chavchavadze State University, Sport Departament, Georgian Dzudo National Federation, Tbilisi, Georgia


In the article there are described the methods of observing sportive results for youth in future. One part of the children who were examined, had been exercising by the meanings of general physical preparation, other group – by the specific preparation, and the dynamics of developing their physical and functional systems, which was made by observing these two groups – gave us the abilities for interesting and helpful recommendations to couches for correcting the process of exercising.


26. T. Gabelia, L. Japaridze, E. Saluqvadze, T. Kvernadze, N. Burkiashvili

Fe-askangel and its Application for Treatment of Iron-Deficiency Anemia

J. Experimental and Clinical Medicine, 2010, 4, pp.89-92


Petre Melikishvili Institute of Physical and Organic Chemistry, Tbilisi, Georgia


Physicochemical method of adsorption modification of superfine askangel (Askana, Ozurgeti, Georgia) with the coordination compound Fe (II)-fructose has been developed. The results of the investigation show that the adsorption of Fe (II)-fructose on the superfine askangel has a  physical character.

On the basis of the clinical tests, possibility of application of Fe-askangel as an effective blood restorative agent for treatment of iron-deficiency anemia has been shown. 



27. Khunashvili N., Kverenchkhiladze R., Tsimakuridze M., Bakradze L.

State of Physical Factors of Environment of Tbilisi Subway

J. Experimental and Clinical Medicine, 2010, 4, pp.92-98


Department of Environmental Health and Occupational Medicine, Tbilisi State Medical University,  Georgia


Based on complex investigations there is established the unfavorable state of environment physical factors of Tbilisi subway –  noise, vibration, lighting. Parameters of noise and common vibration in most of cases exceed the acceptable levels.  The noise is broadband, exceeding  the level, basically, on middle and high frequencies of the spectra. The degree of  exceeding the noise level depends on noise regime  of  premise - at movement of rolling-stock the noise level  reaches up to 108 dB, exceeding the limit acceptable level by 28 dB. The parameters of common vibration at movement of rolling-stock exceeds the limit acceptable level by  9 – 20  dB. State of lightening is characterized by unfavorable   parameters that requires the significant effort of visual analyzer function. The level of satisfaction of the lightening standards in average consists 88-95%. Investigations conducted became the basis of elaboration of complex sanitary measurements on regulation of the noise, vibration  and lightening in  premises of Tbilisi subway.


28. Meskheli M., Antelava N., Bakuridze A., Bakuridze K., Berashvili D.

Effect of Berberin obtained from Ðhållodendron Lavalei, introduced in sub tropic areas of Georgia on Blood Glucose level and Glucose Tolerance in Experiment

J. Experimental and Clinical Medicine, 2010, 4, pp.98-101


Tbilisi State Medical University, Georgia


The effects of Berberin were studied on blood glucose level and on glucose tolerance in experiment in mice. Berberin is obtained from Ðhållodendron Lavalei, this plant is introduced in subtropic areas of Georgia – Kobuleti region. Measurement of blood glucose level was carried out on fasting animals using glucose meter “GlucoLab” – auto-coding. The study revealed that preparation has a hypoglycemic activity, especially improves glucose tolerance in mice and lowers blood glucose level in normoglycemic mice. In conclusion the possible use of Ðhållodendron Lavalei as a plant raw material for obtaining Berberin Hydrochloride for its hypoglycemic activity needs to be decided after further study of efficacy, mechanism of action of extracts and active components of Ðhållodendron Lavalei on experimental models of diabetes mellitus.



29. Chikviladze D. P., Gachechiladze Kh. E., Metreveli D. A., Mikeladze M.L.

Microbiological investigations while suppurative infections of the skin

J. Experimental and Clinical Medicine, 2010, 4, pp.101-104


Tbilisi State Medical University, Department of Microbiology and Immunology, Georgia


In this article there are represented results of investigations of feasible agents of suppurative skin infections (furunculosis, carbunculosis) and there sensibleness/resistance to various groups of antibiotics. During investigation were studied 95 strains of  S. aureus, obtained from patients (age ranged from 25 to 60 yaers) which suffered from furunculosis and carbunculosis and were treated in 2005-2008 years. Sensibleness and resistance of obtained strains to antibiotics of different groups was stadied using method of serial delutions in agar. High frequensy of sensibleness of obtained S. aureus strains was found to vancomycin (98,8%), linezolid (96,4%), netilmicin (94,4%), trimetroprime/ sulphametocxazol (93,8%) and also to antibiotics for local use - fusidic acide (97,9%) and mupirocin (98,5%). High frequensy of resistance of obtained strains was found to ciprofloxacine (42,1%), tetracycline (51,8%), chloramphenicole (38,5%), clindamicine (28,2%), erithromycine (53,8%), gentamicine (60,3%), oxacilline (46,3%), levofloxacine (43,6%), lincomycine (53,8%), rifampicine (40,1%). 55,5% were methicillin-resistance Staphylococcus (MRSA). Polyresistante were only 47,3% of obtainded S. aureus strains.

Effectiveness of empiric antibioticotherapy of skin infections depends on local datas about antibioticoresistance.





J. Experimental and Clinical Medicine, 2010, 4, pp.104-107


Surgical Department of N. Kipshidze Central University Clinic Ltd, Tbilisi State Medical University, Georgia


It must be mentioned that one patient had antibiotic idiosyncrasy. In spite of this , his abscess cavity was closed later against the background of corticosteroid involvement. Out of 23 pacients of the given group, 3 were taken to the ambulatory regimen 7-8 days after the treatment had been started. One of them continued treatment in another hospital and two - at home. During the process of treatment two catheters were transfered from the abscess cavity and because of that it became necessary to carry out the reposition of the catheters. Prolonged transnasal drainage of the lung abscess saves patients from the repeated and frequent bronchoscopy examinations, reduces the period of recovery and treatment expences.


31. Benashvili N., Gvakharia V., Machitadze N., Gelashvili N., Khomeriki L., Khukhunia Ts.

Bottom Sediments in the Downstream Sections of the Black Sea Basin Rivers of Georgia

J. Experimental and Clinical Medicine, 2010, 4, pp.107-112


Al.Janelidze Institute of Geology; St.Andrew the First-called Georgian University of the Patrichy

of Georgia; Scientific Firm “GAMMA”, Tbilisi, Georgia


Bottom sediments of the rivers of the Georgian Black Sea basin have been studied. The grain size parameters, the content of metals (Fe, Mn, Cu, Zn, As, Ni, Cr), organic carbon and total petroleum hydrocarbons have been determined. On the basis of a comparison with previous studies, tendencies in the alteration of the content of metals have been established; a linkage between the lithology and the chemical composition of the bottom sediments has been established.         


32. Lebanidze B., Papashvili I., Gvakharia V.

Modern Dynamics of the Eastern Coastal Zone of the

Black Sea at Poti City

J. Experimental and Clinical Medicine, 2010, 4, pp.112-117


A.Janelidze Institute of Geology; St.Andrew the First-called Georgian  University of the Patrichy of Georgia; Scientific Firm “GAMMA”, Tbilisi, Georgia


The Black Sea coastal zone character near Poti-city varies strongly, which is caused by significant amounts of sediments brought in by the river and by frequent changes of riverbed locations during certain historical periods. Especially notable changes took place during the 20th century, as the hedging breakwaters of Poti port had been constructed and Poti city began to develop.  After 1939 the main branch of the river was removed from the underwater canyon source and directed to the north of the port. As the result, the south coast of the port began to suffer under washing erosion, and the sea covered 300 ha of the land. North to the port a new delta was created and the total growth of seashore territory, up to the river Khobi tributary, reached 1 100ha.  Comparable lifting of sea level, considering the land descending (39cm) and the Black Sea eustatic elevation, reached in the mentioned period 53cm. Nevertheless, accumulation at the whole territory of Poti seacoasts is predominant, which indicates at the strong positive influence of the river brought sediments. 



33. Gelashvili N.G, Maisuradze G.V, Gvakharia V.G.

Determination of Petroleum Hydrocarbons in Georgian sector

of the Black Sea

J. Experimental and Clinical Medicine, 2010, 4, pp.117-121


A.Janelidze Institute of Geology; St.Andrew the First-called Georgian  University of the Patrichy

of Georgia; Scientific Firm “GAMMA”, Tbilisi, Georgia


The article delivers materials which may be useful for people involved in surveys of oil and oil products in the environmental elements and assessment of their ecological role. It also delivers findings of our researches relating to oil pollution level within Georgian sector of the Black Sea, as well as pollution sources and nature (technogenic, natural).



34. Zedginidze A., Antelava M., Gvimradez Kh., Gagoshidze M., Manjavidze N .

Particularities of Cytogenetic Disorders  at the Impact of the Ecological Chemical Mutagens on the Human Organisms

J. Experimental and Clinical Medicine, 2010, 4, pp.121-124


Tbilisi State Medical University, Georgia


The investigation of the chemical mutagens impact on the organisms of children and adolescents living in the arsenic polluted environment gave us the opportunity to detect that the character of the cytogenetic disorders differs from the earlier detected disorders at the  impact of the physical mutagens. The level of acrocentric chromosomal associations didn’t give us the chance to ascertain the fact of the mutagen impact. Chromosomal aberrations are presented mainly as the exchange disorders, and as   micronuclei only  detects  the fact of the mutagen impacts,  not giving the chance to judge their quantitative parameters.


35. Gagoshidze M., mandjavidze N., Aladashvili L., Gogberashvili K., Shanidze V.

Estimation of risk factors at children’s age in the conditions

of action Arsenic

J. Experimental and Clinical Medicine, 2010, 4, pp.124-128


Tbilisi State Medical University, Georgia


The work purpose is: studying of influence of the environment polluted by arsenic on indicators of health and disease of children and teenagers and an estimation of risk factors. Research of children and teenagers has been carried out a current of 10 years for the purpose of studying of influence of the environment polluted by arsenic living in Lukhuni gorge in the territory adjoining to a point of production factory of mountain-chemical arsenic, and a children’s cohort of the same age and with the same social and economic conditions living on rather remote territory, in the conditions of the weakened action of arsenic (Randomization control) - In total 878 children.

The assessment of a risk factor with use of a quality monitoring has been given; relative and attribute sizes of risk of conditions of the environment polluted by arsenic and an authentic interval on their groups for each factor are estimated. An assessment of a difference between groups spent criterion c2 (Pearson). For quality indicators and for quantitative criteria t,  the difference was considered authentic if c2>3,84, p<0,05 and t>1,96, p<0,05. The Software is carried out with use of package SPSS of 11,5 programs.

On our researches in conditions environment polluted by arsenic in Luhuni gorge, in comparison with Ambrolauri and near location villages, marked increase in risk of pathological pregnancy, in particular premature birth; the average data of the basic indicators of physical development specifies on statistically authentic left; at children of school age considerable deviations in health, authentic growth of disease by acute respiratory and other infections are marked.


36. Tukvadze Sh.

Study of factual nutrition in children, from “children’s house”

J. Experimental and Clinical Medicine, 2010, 4, pp.128-132


Department of Environmental Health and Occupational Medicine

Tbilisi State Medical University, Georgia


We studied factual nutrition in children living in “children’s home”. Proper nutrition in childhood can reinforce lifelong eating habits that contribute to children’s overall well being and help them to grow up to their full potential and a healthy life. Good nutrition means body is getting all the nutrients, vitamins, and minerals it needs to work at its best level. Energy (calories) should be adequate to support growth and development and to reach or maintain desirable body weight. Nutritional requirements rise as children begin puberty in order to support sexual development.  A diet that provided sufficient calories and nutrients during childhood may no longer be sufficient for a child beginning puberty. Qualitative and quantitative analysis of children’s diet revealed some irrelevances: disbalance between carbohydrate, lipid and protein composition and disbalances in micronutrients (Iodine, iron, zinc). Such disbalance of micronutrients in the diet can eventually lead to iodine, iron and/or zinc deficiency.


37. Ioseliani D., Kalabegashvili N., Balarjishvili G., Samkharadze L.,

Alavidze T., Ebralidze K.

Effect of pollution of Kvemo Kartli region’s rivers on the health of population and ways of its prevention

J. Experimental and Clinical Medicine, 2010, 4, pp.132-135


Tbilisi State Medical University, Georgia


In the work are considered indices of hydrosphere and soil pollution as the result of activity of JSC Madneuli Mining Company (ore mining and processing enterprise), the largest enterprise of the one of the most important agriculture regions of Georgia and results of its effect on the health of region’s population.

The new technological method of purification of quarry sour waters is offered that secures selective separation of heavy metals and improvement of ecological situation in the region and, respectively, of the health of population.


38. Gorgaslidze N., Bakuridze K., Gongadze N., Nizharadze N., Shengelidze N.,

Surmava N., Makharadze T.


J. Experimental and Clinical Medicine, 2010, 4, pp.135-139


Tbilisi State Medical University


Our investigations were carried out on citizens from different towns of Georgia. Inquiry of respondents has been made by telephone conversations with the help of preliminary questionnaire for fill in the special cards. Each of this form includes questions about their age, sex, profession, constitution and medical or pharmaceutical education. After collection of demographic information on the second stage we checked up the informative level of respondents concerning antibiotics. The questions included their knowledge about proper using of antibacterial drugs, the routes of their administration, possible adverse effects, complication, indication and interaction with other drugs. During our study it was revealed that half of respondents have a lack of information about proper use of antibiotics. A part of them thinks that antibiotics are usual drugs of choice against fever, influenza and mycotic diseases. More than 40% of them consider that antibiotics refer to OTC drugs and they can use them for self-medication in different conditions. After our investigation we came to the conclusion that improving the present condition needs introduction of essential drug list for physicians and pharmacists as well as minimization of self-medication and increase delivery of medical information among population.  




J. Experimental and Clinical Medicine, 2010, 4, pp.139-143


Tbilisi State Medical University, Georgia


Since derivate of 3-(2’-p-methoxyphenylvinil)-IH-pyrrolo[2,3-]-quinoline by its chemical structure is similar to indirect anticoagulants such as warfarine, we have studied the action of this substance on the coagulation system and on the liver of rats. It was shown that using of 3 -(2’-p-methoxyphenylvinil)-IH-pyrrolo[2,3-]-quinoline in a dose o,o6 mg./kg. manifested anticoagulative effect  without toxmorphological and functional parameters  in rats. It was shown that using of  3-(2’-p-methoxyphenylvinil)-H-pyrrolo [2,3-]-quinoline in a dose 0,06 mg./kg. manifested anticongulative effect without toxic changes of liver morphological picture and functional parametrers, which was correlated to its chemical structure. It was suggested that the new substance with closely relationship by chemical structure to warfarin revealed the similar anticoagulative effect without any pronounced changes of liver morphological picture and functional parameters.



40. Barnabishvili N.,  Gamtsemlidze P., Mirtskhulava M., Barbakadze Z.,

Pkhaladze Z.,  Mirtskhulava N., Zaridze K.

Etiology Role of Some viruses in Prevalence  of Bronchial Asthma

J. Experimental and Clinical Medicine, 2010, 4, pp.143-146


National Center for Disease Control and Public health,  Georgia, Tbilisi


Was researched 160 Childs of 2-16 age diseased by Bronchial Asthma in Georgia. Data analysis showed that contacted Viral infections contains the risk for asthma development. The most risk has adenovirus - 1,4286 (Risk ratio) and RS Viruses 1,5714 (Risk ratio), but in case of Parainfluenza correlation  is less expressed  – 1,25. and whether some viral infections are enduerd at the same time, of course  risk is nearly the same in cases of two or three infections as in separate infection – 1,55. It must be mentioned that 6,25%  of investigated children, who had acute RS viral infection, previously had suffered from Parainfluenza and adenoviral infection. Registered viral diseases contacted in early age gives us opportunity to calculate risks of spreading disease with other viral diseases in children age with asthma and present risks of viral infections contacted in early age which have great concern in spreading of asthma.



41. Shavianidze G., Shavianidze M., Lomidze G., Lomidze N.

Balneoextension therapy in rehabilitation of patients with osteoartrosis

J. Experimental and Clinical Medicine, 2010, 4, pp.146-149


The Russian Scientific centre of regenerative medicine and balneology. Moscow;

Tskhaltubo branch of Tbilisi Balneological resort-scientific and practical center of health resort managing, Physioterapy, rehabilitation and Medical Turism, Georgia


Osteoarthrosis – is degenerate-dystrophic disease of the joints, one of which major factors of generating are loadings. The researches carried out by us have allowed to develop a new method - extension of joints, with inclusion in a complex balneotherapy, including resort balneotherapy in Tshaltubo. Carrying out of extension of joints has demanded working out of techniques of treatment and the adaptation for atmospheric and underwater application which have been patented. The received direct and remote results have revealed that a rehabilitation course of bottom finiteness sick of underwater horizontal extension in the conditions of a resort, authentically exceeded results of other complexes; at “dry” extension of the expressed anti-inflammatory effect at patients with sinovite is noted. The received results have allowed to prove scientifically expediency of application extension at is degenerate-dystrophic diseases of joints and to create the new rehabilitation complexes including extension of joints, balneotherapy and resort treatment.



42. Tsanava Sh., Chokheli M., Mgeladze G., Egoyan A., Mirtskhulava M., Imnadze P.


J. Experimental and Clinical Medicine, 2010, 4, pp.149-152


National Center for Disease Control and Public Health, Georgia, Tbilisi


In this work we discuss the structure and basic principles of the automated control system for laboratory research (ACSLR) developed in the Georgian National Center for Disease Control and Public Health (NCDC&PH). The computer network database software developed by the means of modern information technologies will improve coordination between the research laboratories of NCDC and regional laboratories and facilitate their management and administration, and will provide patients and doctors with reliable and operative information on the research results and statistical forms. 



43. Tsimakuridze M., Kverenchiladze G., r.zabakhidze, Zurashvili D., Maisuradze E.

Peculiarities of health state of the chemical industry workers

in Georgia

J. Experimental and Clinical Medicine, 2010, 4, pp.152-155


Institute of Labor Medicine and Ecology, TSMU – Department of Environmental Health and Occupational Medicine, Tbilisi, Georgia


A study has been conducted regarding the influence of working conditions on workers’ state of health at an enterprise “AZOT” in Rustavi, which produces ammonia nitrate and sodium cyanide. It was determined that during the production process workers were afflicted with hazardous chemical compounds, high temperature and industrial noise. It was distinguished that labor conditions of the industry in question were in unfavorable state.

The clinical examination of the workers with basic professions in the field of the chemical industry shows the frequent cases of the diseases that can be divided into three groups: occupational (chronic toxic bronchitis, radiculoneuropathy, osteochondrosis), industrial (cardiovascular diseases) and general. This confirms the major role of occupational and production factors in the etiology of those pathological conditions. On the basis of carefully performed study a list of recreation measures has been carried out in order to improve the working conditions of the employees.


44. Khachapuridze N.A., Zurashvili D.G., Tsimakuridze M.P., Kvartskhava M.L.,

Tsimakuridze Maia P., Kajrishvili M.G.

Peculiarities of immunological   state of occupational diseases

caused by manganese

J. Experimental and Clinical Medicine, 2010, 4, pp.155-158


TSMU, Department of Environmental health and Occupational medicine, Tbilisi, Georgia


The aim of the research is to discover immunologic indicators in patients suffering from occupational pathology caused by manganese. Peculiarities of immunological shifts have been determined such as diminishing quantity of T-lymphocytes, violation of the ratio of helper and suppressive subpopulation while the quantity of B-lymphocytes stays the same; disimmunoglobulinemia, characterized with decreasing IgG and IgA and increasing IgE levels, while IgM remains the same in the case of workers with bronchial asthma. Patients suffering from manganism are characterized with decreasing numbers of T-lymphocytes, helpers and suppressors; increasing number of B-lymphocytes, decreasing IgG and IgA, while IgM is the same.

The obtained information allowed us to determine the immunologic background of the examined patients. It gave a start to subsequent research towards preventive pathogenetic measures of an occupational pathology caused by manganese.



45. Mgebrishvili S. A., Barbakadze I. J.

Parafunction of masseters, diagnostics and treatment

J. Experimental and Clinical Medicine, 2010, 4, pp.158-161


Tbilisi State Medical University, Georgia


Under observation were 87 students aged 21-25 of stomatological faculty of the IV year. All the students were examined. There were collected the anamnesis. In the specially made cards we mentioned and gave great consideration to the complaints where students pointed out to rising of tonus of masseters, toothache, gum scratching, headache and aches in the area of temple-lower jaw joint.

As a result of research it was revealed that from 7 (8%) students from 87 ones complained of scraping teeth, especially at night, after what they had toothaches and headaches, bleeding gums, stretching of muscles in the morning. Objectively, after myotonic research it has been revealed rising of tonus of chewing and temple muscles. Roentgenologically it was mentioned the symptoms of teeth overloading. From the mentioned 7 students’ 4(6%) models study it was revealed that on the upper and lower jaw masticatory teeth was mentioned cone wearing. They were held physiotherapeutic, psychological, medicament and orthopedic treatments.

In 3-4 months after treatment, as a result of repeated researches, it was revealed that chewing and temple muscle tonus was in norm. Roentgenologically, the symptoms of functional overload were not mentioned. The students didn’t complain about headaches and toothaches, scraping teeth, overload of muscles. 

So, parafunction of masseters – bruxism – treatment has to be complex. Particularly, it has to include the psychotherapeutic, physiotherapeutic and orthopedic methods.



46. Mgebrishvili S.A., Barbakadze I.J.

Bow prosthesis fixation elements and problems connected to them

J. Experimental and Clinical Medicine, 2010, 4, pp.161-163


Tbilisi State Medical University, Georgia


There were 53 patients under observation, from whom 28 people from I group were prepared bow prosthesis of NEI system with I, II and III type catcher supporter clasps, and II group 25 patients were made bow prosthesis, fixation of which were made by the help of attachments. As a result of research it was revealed that bow prosthesis fixation in I and II group patients was satisfactory and chewing effectivity was high. But from I group patients 17(60%) of patients after finishing of orthopedic treatment mentioned raising of sensitivity from the side of abutment teeth, and 8 (28%) patients who had parodontopathy in 10-14 months after finishing of treatment had abutment teeth I quality shaking. It is also considerable that for all the patients of I group, catcher supporter clasps were aesthetically unacceptable. For II group patients the aesthetic side of bow prosthesis was satisfactory. But as a result of research it has been revealed that from II group 12 (48%) patients having parodentium, shaking of abutment teeth was mentioned in 14-17 months after finishing of treatment, and in the patients having healthy parodentium, shaking of abutment teeth was mentioned in 2-3 years after treatment. So, while orthopedic treatment of partial adentia, fixation elements of bow prosthesis – as NEI system catcher supporter clasps as attachments require further improvement.





J. Experimental and Clinical Medicine, 2010, 4, pp.163-167


Tbilisi State Medical University (TSMU), Department of  Preventive Medicine and Environmental Health, Georgia


The aim of the research was study and hygienic assessment of radionuclide content of potable water in some mountainous regions of Georgia.

Materials and methods of study. Radionuclide identification of potable water of Tianeti, Dusheti, Stefantsminda districts of Mtskheta-Mtianeti region and Ambrolauri, Oni, Lentekhi districts of Racha-Lechkhumi region have been studied. 

The radionuclide identification of water samples was fulfilled by use of multichannel alpha-, gamma-spectrum analyzer (Cambera Industries).

Results. In the water samples from Mtskheta-Mtianeti and Ratkha-Lechkhumi region presence of natural radionuclides have been observed, especially K-40, which was about 10 times more than the specific activity norms of radiation safety (NRS-2000). The amount of other natural radionuclides were found to be normal. The specific activity of Pb-212, Th-234, U-233, Te-123 were exceeded norms. In some cases were found the radionuclides of artificial origin - Sr-85, I-131, Cs-137, Hg-203. 

Conclusion. The specific activity of radionuclides in the waters of studied territory in some cases is more than acceptable (in some cases – very high). Therefore, internal dose of irradiation of population presumably will be high. To reduce the internal irradiation dose of population it is necessary to prohibit the use of high activity water for drinking and provision of the population with new sources of low activity water.

To reduce the total irradiation dose of population it is also necessary to control and minimize irradiation doses from artificial sources including means of regulation of medical radiological procedures and rational use of fertilizers with K-40 content.







J. Experimental and Clinical Medicine, 2010, 4, pp.167-168


National Centre of Disease Control and Public Health;

G. Natadze Scientific-Research Institute of Sanitary and Hygiene, Tbilisi, Georgia


The study of pollution of basic environmental objects- water, soil and free air with toxic heavy metals has become very important lately, which is a certain pathogenic factor for people and live organisms. The purpose of this work was to study pollution degrees of environmental objects (water, bottom sediments, air), connecting to mining and processing production in Chiatura, to estimate risks and to introduce innovational technologies. As a result of this work it was found out that pipe-line drinking water in Chiatura is polluted according to microbiological indicators and it is not reliable from epidemiological point. High content of dissolved manganese is noted in the well water of general use. Increased alkaline content of surface water, increased electric conduction and temperature of water point to intensive growth of pollution of the river Kvirila by sewage from central processing factories, by ore remainders, so called “tails”, located on the banks of the rivers and streams Shukruti and Darkveti.





J. Experimental and Clinical Medicine, 2010, 4, pp.169-172


The State Research Institute of Hygiene and Sanitary, Tbilisi, Georgia


The rapid non-representative nutrition survey was carried out in 2005 by the State Research Institute of Hygiene and Sanitary of Georgia (SRIHS) with the financial and technical support of the United Nations World Food Programme (WFP). The survey aims to obtain data and information on nutrition status, iron and iodine deficiencies, short-term hunger, concentration and learning capacity, enrolment and attendance rate of primary school children in ten schools located in the most disadvantaged communities of six most vulnerable regions of Georgia.






J. Experimental and Clinical Medicine, 2010, 4, pp.172-175


Scientific Center of Radiobiology and Radiation Ecology Georgian Academy of Sciences,

Telavi State University


Influence of power frequency electro magnetic field (EMF) in rats induce some deviations in formation and retention of passive avoidance reaction. In particular during actions of power frequency EMFs animals behavioral act‘s implementation is embarrassed and this has breaking influence on passive avoidance reaction in rats. Animal‘s nervous tension, amazement and disability to solve given task is clearly noticed. And as to impact of plant composite here is obvious influence of this elixir. In animals it inhibits emotion and increase probability of right decision acceptance comparing as to control so to process of stress impact too.




J. Experimental and Clinical Medicine, 2010, 4, pp.175-177


Tbilisi State Medical University, Georgia


Establishment the corelation between diagnostical important atherosclerosis markers and intensity of oxidative stress in blood of postmenopausal women.

It was revealed, that dislipidemy and obesity induces intensification of atherosclerosis in postmenopausal women. In the hiperoxidative inviroment oxidation of vasodilatator nitric oxide takes place. As a result free nitric oxide content decreases in blood; anigilation of vasodilatatory activity of blood induces development of hypertension in postmenopausal women.   





J. Experimental and Clinical Medicine, 2010, 4, pp.177-179


Tbilisi State Medical University; Institute of Medical Biotechnology; Iv.Javakhishvili Tbilisy State University, Georgia


The aim of the study was establishnent of role of FSH in pathogenesis of bile stone desiase in menopausal women’s blood. The bile stones of 30 women aged 52,4 ± 9,7 year was studied (2 women with surgimenopause (33-35 year). Stonse EPR spectra registrated on the EPR spectrometer ESR-V. In stones EPR spectre the intensive signal of oxidated bilirubine (g=2.003 , H=1.0ìmTl) was revield. The statistical importnt negative corelation was revialed between content of bilirubine EPR signal intensity in the stones and content of FSH in blood of  menopausal women.

It was concluded, decresing of the level of  FSH in blood of postmenopausal women  decreases secretion of melatonis level, which by itseld induces oxidation of bilirubine, iniciation of oxidative stress an development of bile stone desiase in postmenopausal women.





J. Experimental and Clinical Medicine, 2010, 4, pp.179-182


Petre Melikishvili Institute of Phisical and Organic Chemistry, Tbilisi, Georgia


A method has been developed to obtain nitrogenous fertilizers of prolonged action with the purpose of protection of environment from pollution.

Such fertilizers are highly efficient, they contribute to efficient assimilation of nutrients by plants, impede washing out of nutrients and protect environment from pollution. The new type nitrogenous fertilizer obtained by us – structured carbamide is characterized by great advantage compared with the non-structured type. Economy  by application of such fertilizer equals to 50%.




J. Experimental and Clinical Medicine, 2010, 4, pp.182-185


Iv.Javakhishvili State University of Tbilisi, Department of Critical and Emerjency

Medicine, University Clinical Hospital, Georgia


The cases of intoxication by copper sulfate (CuSO4) is known in the countries where the vitalculture is developed because the copper sulfate is used there as a pesticide. Despite of this there are describtions of poisoning by copper sulfate when the way of intoxication is traditional (ingestive). Poisonings usually are accidentally or suicidal in nature. But our case is absolute unique because the copper sulfate was leaded in intravenous to get to suicidal mode.

The case is about a 21 year-old man, who was consumed with suicidal intensions  and leaded in 5 ml concentrate solution of copper sulfate with syringle. So in this case all the symptoms of acute intoxication by copper sulfate expressed. The only indication which is not typical for the acute peroral intoxication by copper sulfate are was the fast developing of respiratory distress-syndrome. The patient was treated by the complex treatment and was left the hospital in a well condition of health.