J.EXPERIMENTAL  &  CLINICAL  MEDICINE

 

2012, 5

 

1. N. JAVAKHISHVILI

NEW ATTACK FROM DIABETES

J. Experimental and Clinical Medicine, 2012, 5, pp.22-24

 

TSU Institute of Morphology, Tbilisi, Georgia

 

Clinical medicine is faced with a new challenge: induction of diabetes in patients who underwent transplantation performed major organs (kidney, heart, liver) - post-transplant diabetes mellitus - PTDM. According to the different services, the frequency of initial detection PTDM ranges 10-32% (and in these patients before surgery, there were no signs of diabetes). The paper also addresses some of the mechanisms of  PTDM formation.

 

 

2. Gagnidze Ts., Korsantia N.

AESTHETIC AND ANTI-AGING MEDICINE, BASIC PRINCIPLES OF COMPLEX THERAPY

J. Experimental and Clinical Medicine, 2012, 5, pp.24-27

 

Caucasus International University, Tbilisi State Medical University, Georgia

 

 Article presents modern information on the aims and objectives of anti-aging and aesthetic medicine. Anti-aging programs aim at identifying the causes of aging of an organism and drug correction of these disturbances that can improve the quality and duration of life. Modern aesthetic medicine basically includes the non-invasive medical procedure that helps removal of cosmetic defects. Both speciality makes decision on their range of tasks, just crossing only in the work of with certain aspects of aging, where they do not compete but successfully supplement each other.

 

 

 

3. Shiralieva R.K., Babayev A.M., Gasanova E.A., Abasova L.I.

Hypertensive encephalopathy at patients with

arterial hypertension (prevention and treatment)

J. Experimental and Clinical Medicine, 2012, 5, pp.28-31

 

Scientific Research Institute of Cardiology, Department of Neurology Diseases, Azerbaijan, Baku

 

The article contains systematized literature data and results of owe research concerning  cognitive disturbances in patients with different stage and durability of arterial hypertension (). It was shown that in patients with AH with emotional disturbances combination of antihypertensive of therapy with different anxiolytics make positive influence on clinics and prognosis of and could in some cases predict the progress of cerebrovascular disturbances.

Moreover, it is necessary to stress, that treatment with combination of antihypertensive of therapy with anxiolytics positively influence on cognitive functions and regressed symptoms of hypertensive encephalopathy, which, altogether, improved clinical state, functional status and quality of life in patients with .

So, applying in time prophylactic treatment with using antihypertensive drugs having certain cerebroprotector abilities and correction emotional make positive influence on clinics and prognosis of , prevent the progressing of cognitive disturbances and symptoms of hypertensive encephalopathy.

 

4. TSOMAIA I., CHURGULIA E.

Classification of Processes at a pharmaceutical enterprise

J. Experimental and Clinical Medicine, 2012, 5, pp.31-33

 

Sokhumi State University, Tbilisi, Georgia

 

Drug manufacture is a range of different interrelated and interacting processes. Their classification will make it possible to alleviate problems in selecting the personnel responsible for the processes, in estimating the resources required to execute processes, and in developing the documents needed for a pharmaceutical enterprise.

 

5. Tsomaia I., churgulia E., SKHIRTLADZE A.

Development stage composition of suppositories - mathematical planning

J. Experimental and Clinical Medicine, 2012, 5, pp.34-38

 

Sokhumi State University, Georgia

 

The papery gives the result of mathematical planning of experiments dealing with the design of the composition of gynecological suppositories. Changes and the magnitude of effects of the composition their  vehicles, such as the type of a thickener and that of a plasticizer, on the results of trials are traced.

 

 

6. Khetsuriani SH.,  Chitaladze M.,  Khetsuriani Z.,  Tsutskiridze A., 

Baazov A., Shervashidze A.

DNA TRANSFORMATION IN ESCHERICHIA COLI  BIOTYPES AND THEIR BIOLOGICAL CHARACTERISICS

J. Experimental and Clinical Medicine, 2012, 5, pp.39-41

 

Center of Scientific Skills, Tbilisi State Medical University, Georgia

 

Escherichia coli is usually considered to be an opportunistic pathogen which constitutes a large portion of the normal intestinal flora of humans. This organism can, however, contaminate, colonize, and subsequently cause infection of extraintestinal sites and is a major cause of septicemia, abscesses, meningitidis, and urinaty tract infections in humans. Several studies have shown that a haemolysin (Hly) production is a frequent and important virulence factor of pathogenic strains.

The aim of the present investigation  was to study of  fecal  E.coli biotypes isolated from patient with colon cancer and examine the possibility of DNA transformation  in vitro. Biochemical tests show high activity in transformant Hly positive strain, than in  Hly negative  and Hly positive  strains, but morphological,  cultural  and tinctorial  properties were typical in these  strains. It is important to study this  topic in large amount of  research in future.

 

 

7. Tsypkun V. A.

PARTICULARITIES OF THE UTERO-PLACENTAL-FETAL CIRCULATION IN PREGNANT WOMAN WITH UNIVERSAL DIABETIC ANGYOPATHY

J. Experimental and Clinical Medicine, 2012, 5, pp.41-46

 

120  pregnant women are inspected: 90 with the 1 type diabetes mellitus  (a 1st group is 50 women with universal diabetic angiopathy, 2nd are 40 women with the insignificant displays of diabetic angiopathy) and 30 healthy pregnant without DM (control group). Undertaken studies educed substantial violations of utero-placental and fetal blood circulation, its expressed  depends on a presence universal diabetic angiopathy. Diagnostic criteria characteristic for the critical condition of fetus are increase of S/D ratio in uterine arteries, artery of umbilical cord and fetus aorta and his decrease in the arteries of fetus brain, and also proof zero or negative values of diastole component of blood stream in the artery of umbilical cord and fetus aorta and decrease of indexes of vascular resistance in the middle cerebral artery of fetus.

 

 

8. Godovanets Y., Yurkiv O.

Features of clinical symptoms, diagnosis and correction of disorders of the gastrointestinal tract in infants with perinatal diseases in history

J. Experimental and Clinical Medicine, 2012, 5, pp.46-52

 

Bukovina State Medical University (Chernivtsi, Ukraine)

 

Conducted a comprehensive clinical and para-clinical examination of infants with perinatal diseases in history, with disturbances of the functional condition of the gastrointestinal tract. Changes revealed intestinal microbiota exacerbate liver dysfunction and biliary tract. Early diagnosis and correction of disorders will improve the functional condition of the intestine in infants and level indications of dysbiosis.

 

 

9. Durglishvili G., Galdava G.

Alternative Treatment of Urinary Infections

J. Experimental and Clinical Medicine, 2012, 5, pp.52-55

 

National Scientific Research Institute for Skin and Venereal Disease, Tbilisi, Georgia

 

According to observation, it should be mentioned that treatment of sexually transmitted diseases (STD) is persistent problem. The reason for this is that the treatment used in the past lost its effectiveness in consequence to prolonged administration. Due to it these microorganisms developed high resistance to used drugs. It should also be considered that certain countries unwillingly use all known guidelines and protocols for treatment of sexually transmitted disease.

Our study showed that in treatment of STF it is reasonable to use the following high efficacy drugs: Vilprofen and Unidox for treatment of Chlamydia trachomatis and Ureaplasma urealiticum and also Naksodzhin for Trichomonas vaginalis. The high therapeutic effect is achieved and fewer side effects were manifested with used of above mentioned drugs.

10. Natriashvili G., Chkhartishvili D., Kapanadze N.

EFFICACY OF CITICOLINE IN CHILDREN WITH HYPOXIC-ISCHEMIC ENCEPHALOPATHY

J. Experimental and Clinical Medicine, 2012, 5, pp.56-59

 

SEU Clinic (The Clinic of Georgian National University), Department of Child Neurology, Tbilisi State Medical University (TSMU), Tbilisi, Georgia

 

Neonatal encephalopathy is a heterogeneous syndrome characterized by signs of central nervous system dysfunction in newborn infants. Clinical suspicion of neonatal encephalopathy should be considered in any infant exhibiting an abnormal level of consciousness, seizures, tone and reflex abnormalities, apnea, aspiration, feeding difficulties.We have observed 175 infants aged 1-5 days (95 boys, 80 - girls) with HIE. Exclusion criteria included prematurity, severe stage of HIE, metabolic diseases, cerebral digenesis, neuroinfections.

Neurological  status were evaluated in all the patients, the pH and blood gas composition was determined. Blood and urine tests, EKG, Echocardioscopy, EEG and neurosonography were done in all cases. Lumbar puncture was performed in 75 patients to exclude of CNS infection, CT - in 87 and MRI in 67 patients. Neurosonography was carried out in every week during the acute period, and then at intervals of 1.5-2 months until the closure of the fontanel. Patients were divided into two groups: I - the main group - 115 patients who received citicoline (50 mg twice a day for 1 month) in the complex treatment of HIE and II - the control group - 60 patients who underwent only syndromological treatment of HIE. The most favorable outcome was observed in children which received citicoline in acute period of HIE.  Adverse outcome - in those patients who had more severe and persistent brain damage according to neuroimaging.

 

11. MALATSIDZE V., KUPRADZE S., KORSANTIA B., BORCHKXADZE N.

STUDY OF PROTECTIVE PROPERTIES OF NATURAL ZEOLITES IN ACUTE AFLATOXICOSIS OF white mice

J. Experimental and Clinical Medicine, 2012, 5, pp.60-62

 

Tbilisi State Medical University, Dept of Inner Medicine and Institute of Medical Biotechnology, Georgia

 

Natural zeolites have the ability to bind toxins, neutralize and destroy them, excrete from organism. Zeolite diet contributed to the activation of phagocytosis in Kupffer cells of the liver and antioxidant protection in intact white mice. Acute aflatoxicosis induced mortality of white mice in 75% of cases. Zeolite diet reduced the rate to 40% and normalized parameters of phagocytosis and hypoxia.

 

12. TODUA L.,   NIKURADZE N.

PREVENTION OF DRY EYE SYNDROME IN SOFT CONTACT OPTICAL LENSE USERS

J. Experimental and Clinical Medicine, 2012, 5, pp.62-64

 

Department of Ophthalmology, Tbilisis State Medical University, Georgia

 

Therefore, our method to prevent development of Dry eye syndrome in soft contact lense users suggests using antixodidant and moisturizing agents. Purpose: Investigation o efficiency of eyedrops Oxial  and Taufon. Methods: The study was carried out on 87 patients. Results and conclusions:   Instillation of antixodidant and moisturizing agents from the first day of starting using contact lenses results in a comfortable  use of soft contact lenses for a long time.