J.EXPERIMENTAL & CLINICAL MEDICINE
2013, ¹ 1
1. M. GIORGOBIANI, I. GANUGRAVA, R. TATARADZE, N. KAKABADZE
G.NATADZE SCIENTIFIC-RESEARCH INSTITUTE OF SANITARY, HYGIENE AND MEDICAL ECOLOGY IS 85-year-old - traditions are a guarantee of future success
J. Experimental and Clinical Medicine, 2012, 4, pp.11-13
G.Natadze Scientific-Research Institute of Sanitary, Hygiene and Medical Ecology,
Primary job of Institute is to secure the human environment, and includes the following topics for disscusion and implementation - concept of environmental care and the creation of a national environmental health plan, the impact of environmental factors on human beings to create a surveillance system, population education in environmental safety via trainings and lectures - seminars.
These issues are the priorities for future research G. Natadze Scientific-Research Institute of Sanitary, Hygiene and Medical Ecology Institute. 85 years of experience in scientific research and sustainable development of Institute today’s demand for sharply defining the priority areas of activity.
2. I.GANUGRAVA, K.KHAZARADZE, B.ZURASHVILI, R.TATARADZE, M.MIRTSKHULAVA, M.GIORGOBIANI
MEDIKO-BIOLOGICAL ASPECTS OF RADON PROBLEMS IN GEORGIA
J. Experimental and Clinical Medicine, 2012, 4, pp.13-16
G.Natadze Scientific-Research Institute of Sanitary, Hygiene and Medical Ecology, TSMU, Department of Preventive Medicine and Environmental Health, Tbilisi, Georgia
Radon problem in Georgia is considered to be very acute problem due to geo-ecological, ethnic-sociological and medico-biological characteristics of the country. XX century is a century of population mass movement from wooden houses into b rick, block and cement block ones, that has in increased radon implementation in dwellings et large scale. At the same time, growing usage of thermal waters and natural gas for heating purposes have worsened the existing radio-hygienic situation. Radon problem in Georgia can be solved through the governmental national program on the basis of modern technology.
3. N.VEPKHVADZE, T.KOCHORADZE, M.KHORBALADZE
RADIOECOLOGICAL SITUATION OF DIDGORI REGION OF GEORGIA
(RADIATION BACKGROUND OF OPEN PLACES)
J. Experimental and Clinical Medicine, 2012, 4, pp.16-18
TSMU, Department of Preventive Medicine and Environmental Health, Tbilisi, Georgia
Radioecological situation of Didgori region of Georgia has been studied (radiation background of open places). Outdoor radiation background of investigated region is in range of 67,2-80,2 nGy/h; average index is 74,6 nGy/h.
The annual effective dose of population for Didgori region caused by outdoor irradiation is in range of 0,12-0,14 mSv/y (average index is 0,13 mSv/y), which is less than the average dose received by most of world’s population from radiation background of open places (0,4 mSv/y), hence to carry out preventive measures for its reduction is not necessary.
4. N.M.SAAKASHVILI, I.D.TARKHAN-MOURAVI, N.A.KAKULIA, M.SH.TABIDZE, SH.V.TSIKLAURI, I.R.KVINIKADZE, N.R.KVINIKADZE
EFFECT WORSENING OF ECOLOGICAL SITUATION, PROVOCATIVE OF CHANGES BY SOME METEOROLOGICAL FACTORS ON HUMAN HEALTH IN TBILISI CITY
J. Experimental and Clinical Medicine, 2012, 4, pp.18-20
Tbilisi Balneological resort “Tbilisi-SPA” - National scientific and practical
center of health and medical rehabilitation; Department of health resort managing
and medicinal tourism of Tbilisi State Medical University, Georgia
Clinical examination of 463 persons, inhabitants of populated Tbilisi city.
Among these persons essential hypertension of I-II stages was noted in 72, ischemic cardiac disease with a stable stenocardia of tension of the I-II functional classes– in 86, light form of bronchial asthma – in 80, chronic non-obstructive bronchitis - in 76, intermittent allergic rhinitis – in 75. 74 persons were practically healthy.
It has been established, that increase of water evaporation elasticity by 10 millibar and more in 1 m3 of the air and passing of atmospheric fronts induce the origin of meteotropic reactions of one or another intensity in the examined persons.
5. G. Dvali, D. Popkhadze, M. Lezhava
Aflatoxins in some food products and in raw materials
J. Experimental and Clinical Medicine, 2012, 4, pp.20-22
G. Natadze Scientific Research Institute of Sanitation, Hygiene and Medical Ecology Georgia,Tbilisi
Here are presented the results of aflatoxins monitoring in cashew nuts, child feeding products and in poultry fodder. The frequency of aflatoxins revealing in examined samples (64) is 9 %. Aflatoxins have been found in three samples of nuts from 34. Aflatoxins have not been revealed in child feeding products ( 18 samples). In spite of the small amount of examined samples (12) of poultry fodder, the frequency of aflatoxins revealing is 25%. High concentrations of aflatoxins (10,6 mg/kg; 18,25 mg/kg; 38 mg/kg).
The results of present examinations prove the urgency of aflatoxins problem and necessity of monitoring broadening.
6. M.TSIMAKURIDZE, R.KVERENCHKHILADZE, N.KHUNASHVILI,
MAIA TSIMAKURIDZE, M.KVARTSKHAVA
HEALTH EFFECTS OF TBILISI METRO WORKER’S TRADE GROUP
J. Experimental and Clinical Medicine, 2012, 4, pp.23-27
Tbilisi State Medical University, The direction of Environmental Health and Occupational Medicine, Georgia
The current report refers to the study of Tbilisi Metro worker’s health condition taking into account professional characteristics. The total number of healthy people in the main group is 4.6-times less compared with the control group. This rate is law in the profession of line driver, turner and track electrician. Among the welder profession have not been identified healthy people.
The total number of infected people in the main group is 4.5-times more compared with the control group. The level of identified diseases in the main group is 211.3 on every 100 investigated person. (in the control group this number is 42.9), that is 4.9-times more than in the control group (t=5.1, P<0.001).The high-frequency of health effects, OR and the existence on pathologies among the employed people in the main professions in the control group indicates casual connection of health effects with the labor condition, that means the importance of regulation of recreational activities.
7. M.V.Grdzelishvili, M.B.Mirtskhulava, M.A.Lashkhauri, M.T.Giorgobiani, G.N.Dvali, K.G.Kiknadze, N.D.Shubitidze
Affect of Zestafoni Manganese Processing Plant on Dusting of living area with manganese dioxide
J. Experimental and Clinical Medicine, 2012, 4, pp.27-29
G..Natadze Scientific - Resarch Institute Of Sanitary, Hygiene And Medical Ecology, Tbilisi, Georgia
Many deseases, that previously considered to be as professional ones and appeared only among people employed in the factories, are now found in those layers of population that don’t have any industrial contacts with toxic substansies. The aim of the work was to study the dust quality of residential buildings in Zestafoni and manganese content of dust in order to determine the influence of manganese processing plant. The studies revealed the affects of Zestafoni manganese processing plant on dusting of residential living area, which contained large amount of dioxide manganese. The highest amount of dioxide manganese was revealed in the dust samples taken in the balconies, two third decrease of this amount was observed in the living-rooms and bedrooms of the same area. At the same time, in comparison to the first floor, it is higher in the samples of dust taken in the second floor. Thus, in comparison to Tbilisi control sample (manganese dioxide content< 1,0mkg), Zestafoni residential areas are characterised by high dusting and high manganese dioxide content of the dust.
8. CHIKVILADZE D., METREVELI D., GACHECHILADZE KH., MIKELADZE M.
HYGIENIC ASPECTS OF NOSOCOMIAL INFECTIONS
J. Experimental and Clinical Medicine, 2012, 4, pp.29-34
Tbilisi State Medical University, Department of Microbiology and Immunology, Georgia
Medical equipments, instruments and hands of medical personnel serve as one of the most important vehicles for the transmission of nosocomial infections, and therefore disinfection and sterilization are considered as a main part of any infection control programs. In the article are described the main characteristics of most commonly used groups of disinfectants and antiseptics; are advised principal approaches for the selection of optimal disinfectants, which depends on the type of the disinfecting surface.
9. KURASHVILI B., KVERENCHKHILADZE G., SOKHADZE K.
CURRENT APPROACHES TOWARDS THE PROBLEM OF SECURING FOOD SAFETY
AND OUTCOME OF SANITARY AND HYGIENIC RESEARCH OF SOME ANIMAL ORIGIN FOODSTUFFS
J. Experimental and Clinical Medicine, 2012, 4, pp.34-36
TSMU, Department of preventive medicine and environmental health – trends of nutrition and age medicine; National Agency of food of the Ministry of Agriculture of Georgia, Tbilisi
Our Department analyzed outcome of sanitary and hygienic research of animal origin foodstuffs carried out by the National Agency of Food of the Ministry of Agriculture of Georgia during 2007 – 2012 years. In the course of analyze was identified presence of basic coliform bacteria in products though not a single fact of pathogenic pollution of foodstuffs had been registered. The above circumstance indicates on breach of production technology as well as sanitary and hygienic conditions by the personnel. Growth of identified violations can be explained by the efficiency of operation of the National Agency of Food of the Ministry of Agriculture of Georgia. For the above breaches towards the business operators have been assumed legislative measures and all they received conformable recommendations.
10. R.Javakhadze, N.Chkhaidze, M.Arabidze, M.Gvishiani, N.Khatiashvili, Kh.Shubladze
Labor and health in tobacco industry
J. Experimental and Clinical Medicine, 2012, 4, pp.37-39
N.Makhviladze Scientific Research Institute of Labor Medicine and Ecology, Tbilisi, Georgia
The labor conditions of tobacco industry workers, their health status were investigated. Also there were done the epidemiologic investigations. The employees are under the influence of organic origin disintegration aerosol - allergic dust of tobacco. It’s concentration exceeds the allowed norm with 1,3- 5,7, which equals to the labor norm hazardous 3.2 and 3.3 classes. Noise level in 72,5% exceeds allowed sanitary norm.
According to hygienic classification the worker’s labor conditions of this industry refer to 3.1 and 3.2 class harmfulness, what may be prerequisite of occupational and occupation provided diseases.
By epidemiologic investigations it was elucidated that according to Notkin’s classification taking into consideration the number of cases and days of temporary disability tobacco industry in Georgia refers to medium level. By investigations of worker’s health conditions it was established that mainly in tobacco industry the following systems are damaged-nerve, cardio-vascular, respiratory, digestive, muscular-skeleton and skin. Main reasons of harmful factors are identified; among them are technology process peculiarities, unsatisfied ventilation, inadequate tightness of the major technological components and etc.
Preventive measures have been elaborated based on conducted research.
11. M.I.NIKOLAISHVILI, T.B.MUSELIANI, E.T.PETRIASHVILI, G.M.JIKIA, S.I.ZENAISHVILI
RADIOACTIVE CLASSIFICATION OF NATURAL MINERAL WATERS AND BIOCHEMICAL RESULTS OF RADON THERAPY
J. Experimental and Clinical Medicine, 2012, 4, pp.40-43
I.Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia
It is shown that the patients with head ache, increased excitability, labile arterial pressure etc. have increased basal level of insulin, beta-endorphins in blood and decreased concentration of dopamine. The results of our research show that radon therapy is preventing from development of several diseases caused by the wrong life style.
12. N. I.MAMUCHISHVILI, I.M.MCHEDLISHVILI, P.G.IMNADZE
SOME EPIDEMIOLOGICAL PECULIARITIES OF LEPTOSPIROSIS IN GEORGIA
J. Experimental and Clinical Medicine, 2012, 4, pp.43-45
Center for Disease Control and Public Health; Public Health Department of Tbilisi State Medical University, Tbilisi, Georgia
Leptospirosis presents one of the significant zoonotic diseases in the Caucasus region. As the leptospirosis morbidity study data for 2006-2011 show the disease in Georgia is characterized by the upward trend with the highest level in 2011. The disease is common in all regions although it is widely spread in Ajara, where the prevalence for 2010-2011 five-six times exceeds the country average level. Case-fatality rate for the disease composes 8.7±2.4%,. whilst it achieves 24.3% in the age group of 60 and over. The age group of 30-50 is the most affected, it accounts for 54.8% of the cases.
13. N.GOKIELI, SH.ZARNADZE, M.KUPARADZE, I.MANJAVIDZE, D.KITOVANI, I.ZARNADZE
POPULATION RIGHT OF HEALTH CARE AND NEW CONCEPTION
OF MEDICAL SERVICES
J. Experimental and Clinical Medicine, 2012, 4, pp.45-46
Direction of Nutrition and Aging Medicine of TSMU, Tbilisi, Georgia
The strategy has raised serious concerns about the equity and sustainability of the health system, as well as issues relating to quality and efficiency. Georgia still has a relatively low resource base and the challenge must be to pool these resources in as simple a way as possible in order to purchase services for the population. New policies aimed at reducing out-of-pocket payments by promoting broad participation in private health insurance schemes have to be thoroughly monitored and evaluated.
14. T. DARSANIA, SH. ZARNADZE, I. ZARNADZE
GLOBALIZATION IMPACT OF EATING BEHAVIOR IN GEORGIAN POPULATION
J. Experimental and Clinical Medicine, 2012, 4, pp.47-49
Derection of Nutrition and Age Medicine of TSMU, Tbilisi, Georgia
Currently change is observed in the traditional nutrition and flavors in favor of nontraditional dishes. The aforesaid problem requires a multidimensional analysis. The aim of our work was to assess the problem. Education, culture, eating behavior, traditions and attitudes to the national heritage is often defining behavioral criteria of the broad masses of society. Therefore intellectual accomplishments and technological progress, in most cases determines the formation and adoption of new eating behavior in different social groups, which, in turn, determines the health of the population.
15. E.N.Elashvili, I.G.Velijanashvili, P.G.Imnadze, D.O.Gelovani
Tularemia in Georgia
J. Experimental and Clinical Medicine, 2012, 4, pp.49-51
National Center for Disease Control and Public Health; Public Health Department of Tbilisi State Medical University, Tbilisi, Georgia
Described the situation of tularemia in Georgia. Cases o tularemia registered in Georgia since 1946. Natural zones of tularemia detected in almost all climates of the East. Natural zones include lowland among mountain the eastern ridge of Surami and the northern part of the Caucasus region of Javakheti Meskheti. Natural zones of tularemia is in Shida Kartli (there are favorable conditions for a water rat). Tularemia epizootic designation is the Gardabani region, in Shiraki steppe (the field – vole high amount background) and in Eldari steppe (the red tail-vole high amount background).
16. ZENAISHVILI O., ZAKARAIA TS., GIGAURI T., CHIQOVAN T.
ABOUT SEVERAL ASPECTS OF TOXOPLASMOSIS
J. Experimental and Clinical Medicine, 2012, 4, pp.52-53
S.Virsaladze Scientiﬁc Research Institute of Parasitology and Tropical Medicine; Union “Janmrteli Momavali” (healthy future),Tbilisi, Georgia
Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii. Toxoplasmosis is widely spread in world and interest to toxoplasmosis is growing. Was showed that in researched patients (65) the indicator of toxoplasmosis infection (IgMC, IgG) is high, IgG positive high indicator is noted in patients who have lymphadenitis (25%); 18,7% researched were pregnant, 46,8% - had fever of unknown nature of the infection. The study demonstrated the improvement of laboratorial diagnose of toxoplasmosis and the necessity of enlargement.
16. GIORGADZE T.G., GIORGADZE S.G., MAISURADZE I.G., UTIASHVILI Z.E.,
CLIMATE CHANGE AND HUMAN HEALTH
J. Experimental and Clinical Medicine, 2012, 4, pp.53-55
Training Center of Emergency Medical Response and Management, established at TSMU
Department of Histology, Cytology and Embryology. TSMU Department of Emergency Coordination and Regimen of the Ministry of Labor, Health and Social Affairs of Georgia, Tbilisi
Each year, disasters trigger devastating losses in human lives and economic assets. In particular, climate-related (e.g., hydrological, meteorological) hazards affect this increasing number of people and cause increasingly large economic losses. There is increasing evidence that human health will be affected in many and diverse ways. Although considerable research has been conducted on many aspects related to the geological and biological impacts of climate change, little is known about the specific impacts on the future well-being of the world’s population and how they are related to our ability to adapt to changing climate conditions. Knowledge is still limited in many areas. The purpose of the review - We’re focused on the climate-related disasters, which affect a large population in a widespread geographic region. Describing their general effects on health, it does not pretend to cover every contingency. In - Review of recent literature has shown that the public health consequences of disasters are complex. Climate-related hazards directly impact the health of the population resulting in physical trauma, acute disease and emotional trauma. In addition, they may increase the morbidity and mortality associated with chronic disease and infectious disease through the impact on the health care system.
THE TREATMENT OF CONGENITAL HIP DISLOCATION BY «OVER-HEAD» METHOD
J. Experimental and Clinical Medicine, 2012, 4, pp.56-61
Scientific Center of Traumatology and Orthopedy, Yerevan, Republic of Armenia
This article represents the results of treatment of 264 children with congenital dislocation which were treated by the «over-head» method. The main contingent of children are with late diagnosed hip dislocation in total 235 patients (89%) or with non- repositioned dislocation at this age due to the previous failed treatment of 29 patients (11%). Long-term results from 1 to 5 years were analyzed among 185 (approximately 70.1%) patients. Good and satisfactory results were obtained among 154 (83.2%). Traction by the «over-head» method facilitates closed reduction or reduction occurs during stretching. It is considered to be a physiological and functional method for the treatment of children with dislocation of the femoral head from the 1-4 grades according to Tonys, for the age group of 5 months to 3 years.
In modern literature the issues of conservative treatment of children with congenital hip dislocation (CHD) are widely covered. As we know, the most difficult and crucial step in the treatment of CHD is the process of bringing down the thigh to the acetabulum and the reduction of dislocation, a process which is complicated in direct proportion to age. Regardless of the age of the child, the only principle of treatment should be gradual reposition of dislocation and rejection of forced manipulation. According to the world literature, the greatest number of complications, failures, and aseptic necrosis of the femoral head occur especially during this phase [1,3,4,5,7,9].
INDICATIONS FOR OPEN REDUCTION OF CONGENITAL HIP DISLOCATION
J. Experimental and Clinical Medicine, 2012, 4, pp.62-67
Scientific Center of Traumatology and Orthopedy, Ministry of Health of the Republic of Armenia, Yerevan
In the article the results of treatment of 95 patients with congenital hip dislocation are described, on which open reduction and plastic of capsuloplasty was applied. For 47 patients open reduction was applied after stretching, for 45 combined intervention was made - shortened corrective femoral osteotomy, osteotomy of the pelvis according to Solter and open reduction with capsuloplasty, and for 3 patients only hip osteotomy was applied.
Absolute indication of open reduction is wrong dislocation starting from the age of 3 years and above. For children under 3 years the main indication for termination of attempts of closed reduction and open reduction are organic obstacles preventing closed reduction, which is possible to detect with ultrasonography.
19. N.PAVLIASHVILI, T.PETRIASHVILI, V.KIPIANI, M.TOPURIDZE, D.KARKARASHVILI,
NINO KIPIANI, N.GAMKRELIDZE
DISORDRS OF ERYTHROCYTES’ RESISTANCE AND MICROHEMOCIRCULATION DURING CRUSH SYNDROME
J. Experimental and Clinical Medicine, 2012, 4, pp.67-69
Tbilisi State Medical University, Department of Pathophysiology, Georgia
With the use of cytolysogram method Erythrocytes’ mechanical resistance, with the use of photoelectro-colorymetry method Erythrocytes’ osmotic resistance, and using biomicroscopy the mesenteric microhemocirculation during Crush syndrome in adult male rats has been studied.
Investigations were carried out at different periods of compression – in 3 or 6 hours before compression and on 1, 6 and 12 hours of postcompression period. Experiments revealed that Erythrocytes’ mechanical and osmotic resistance decreases, especially during the decompression period. Microhemocirculation in intact tissues is disordered. Severity of disorders depends on the duration of compression /decompression periods.
Developed disorders of Erythrocytes’ resistance and microhemocirculation could be considered as one of the major reasons of generalized hypoxia developed during crush syndrome.
20. HODOVANETS Î.².
STOMATOLOGICAL STATUS OF CHILDREN WITH CONCOMITANT SOMATIC PATHOLOGY
J. Experimental and Clinical Medicine, 2012, 4, pp.70-71
Department of Children Surgery, Bukovinski State Medical University, Chernivtsi, Ukraine
A stomatological examination of 360 children aged from 8 to 15 years, undergoing inpatient treatment at the endocrinological, gastroenterological and pediatric departments of Regional Ñhildren’s Ñlinical Hospital ¹2, has been carried out. A high prevalence of the basic stomatological diseases has been established: caries and noncarious lesions of the hard tissues of the teeth, pathology of the parodontal tissues, maxillodental anomalies.
21. AGHABEKYAN G.G., SARGSYAN P.G., MINASYANTS M.V.
BITES OF THE ARMENIAN SNAKES
J. Experimental and Clinical Medicine, 2012, 4, pp.72-78
RA, National Bureau of Expertises, Yerevan, Armenia
There are four types of poisonous snakes in Armenia. All of them belong to the viper family. It is important to know that the snake bite is a self-defensive action, which is usually caused by the human carelessness or aggressive behavior. The most complete support in cases of venomous snakes bite is injection of antitoxic serum to the affected person.
Bite of Gyurza snake is dangerous and in case of delayed medical care it can end tragically. Main symptoms of intoxication by Gyurza’s poison are similar to other Viper family snakes and include pain at the site of inoculation of the poison, also development of hemorrhagic edema, which in some cases can reach enormously large sizes. Self-medication is not allowed and it is necessary to take qualified medical aid.
If during the forensic autopsy examiner surmise the poisoning by snake venom, some material shall be taken from the body to search venom antigens. In forensic laboratory the blood, kidneys, liver, skin, lungs, brain, spleen, bladder, different bones, ear of corpse must be investigated.
22. TAVARTKILADZE A.G., KASRADZE D.G., AVALIANI Z.R., MIRZIASHVILI M.G.
RESEARCHING SPECIFIC ,,ENDOCRINE” ACTIVITY OF SQUAMOUS EPITHELIAL CELL CARCINOMAS IN LUNGS AND CERVIX
J. Experimental and Clinical Medicine, 2012, 4, pp.78-80
Cancer Research Center; Departament of pathology, D.Tvildiani Medical University; Georgian University; Tbilisi Central Clinic; Departament of Pharmacotherapy, Tbilisi State Medical University, Tbilisi, Georgia
Oxidation reactions of fatty acids taking place in mitochondria constitute around 65-80% of energy source in cancer cells – active fatty acid is transported into mitochondria through carnation. For the trials we used 12 cases of lung carcinoma and 8 cases of squalors epithelial cell carcinomas of cervix – cellular cultures from surgical and biopsied materials belonging to various patients. We cultivated cancer cells: 1. nutritional areas rich with carnation; 2. nutritional area with identical amounts of carnation as in human blood plasma (control sample); 3. nutritional area without traces of carnation. Metabolically activity of cancer cells was assessed according to existing levels of matrix RNA and total levels of ATP. Metabolism of cancer cells increased by 34.7% in nutritional areas rich with carnation; total ATP levels increased by 75.7%. In the meantime, metabolism in cancer cells decreased by 30.5% in nutritional areas without carnation, and general levels of ATP decreased by 69.1%. Eventually, metabolism data for cancer cells is indirectly proportionate to total levels of ATP in the same cells.
23. B.IASHVILI, N.KORSANTIA, TS.GAGNIDZE, G.KASHIBADZE, B.KORSANTIA
ImmunoTROPE EFFECTS of Camelyn AT THERMAL BURN OF SKIN
J. Experimental and Clinical Medicine, 2012, 4, pp.80-84
Center of Thermal Injures and Plastic Surgery; TSMU Institute of Medical Biotechnology; Caucasus International University, Tbilisi, Georgia
Inclusion different dosage forms of Camelyn (injections, capsules, cream) in complex therapy of a burn disease led to improvement of a clinical condition of patients, faster removal of intoxication, reduction of cases of infectious complications, improvement of reparation processes in skin and faster treatment, than at traditional treatment.
The thermal burn and burn diseases are brings on severe immunodeficiency in the patients, the intensity of which in many ways depends on the severity and extent of the burn, the age of patients, duration of hospitalization. In the most severe forms of the diseases was observed paralysis of some factors of immunity.
Camelyn-therapy has contributed more dynamical correction of immunocompetence of patients (timing and intensity), especially systems of interferon and phagocytosis, which play a leading role in immunorehabilitation.
24. ISAKADZE A.
LOAD TETS 6-MINUTE WALKING
J. Experimental and Clinical Medicine, 2012, 4, pp.84-87
TSMU, Departament of Therapy; The Science Academy Preventive Medicine, Tbilisi, Georgia
During heart and lung diseases in order to evaluate the objectivity of tolerance and functional condition of physical load of patients, 6-minute-walking test can be applied.
Test is simply. Its indication is the assessment of functional condition. There are two kinds of contraindications: absolute and comparative. At the begining and end of the test the shortness of breath according o Borg scale, pulse and blood saturation with oxygen are estimated.
In patients with heart chronic failure the results of 6-minute walking test are concurrent with functional classes of heart failure and oxygen consumption parameters. In order to evaluate the effectiveness of treatment compared with the initial stage the increase of the covered distance by 70 meters is considered minimal significant improvement.
25. ISAKADZE A.
THE HEART MURMUR
J. Experimental and Clinical Medicine, 2012, 4, pp.87-89
TSMU, Departament of Therapy; The Science Academy Preventive Medicine, Tbilisi, Georgia
The heart murmur is relatively long standing voice (vibration), which is derived from turbulence movement of blood. There are the internal and external murmur. The intracardial murmur divided in to organic and functional ones, while extracardial is devided into pericardial, cardiopulomonal and plevrocardial murmur. The organic murmur take place at mitral and aortic valves deficiency and left venous and aortic hole stenosis. Intracardial functional murmur might be dynamic and/or anemic.
Graham-Stell murmur is functional diastolic murmur of pulmonary artery valves. Flint murmur is presystolic murmur of left venous hole relative stenosis. The Flint murmur is left venous hole relative stenosis presystolic murmur. The Kumbs murmur is vasodiastolic functional murmur. The extracardial murmurs are the voice of pericardium attrition and voice of pleuropericardium.
26. Akhmeteli L., Saginashvili L., Dzneladze L.
A Rare Case of Bowel Obstruction due to Tuberculosis
J. Experimental and Clinical Medicine, 2012, 4, pp.90-91
TSMU Department of Surgery N1, Direction of Surgical Diseases, Tbilisi, Georgia
Tuberculosis is one of the rare causes of bowel obstruction. The intestinal form of tuberculosis may occur together with lung tuberculosis or isolated. Despite the fact, that tuberculosis is mostly responding to the conservative treatment, complicated intestinal forms often require surgical treatment. In the case of intestinal obstruction due to tuberculosis, a character of surgical intervention is determined by localization of the process, presence of adhesions in the abdominal cavity and patient’s general condition.
The article describes the history of 62-year-old woman’s disease, who was admitted to hospital with a diagnosis of intestinal obstruction. During surgery it was found out that the wall of terminal loop of small intestine and ceacum was thickened, compressed, lumen of the bowel was narrowed. The diagnose of Crohn’s disease was suspected. Resection of the ileum and right colon, followed by with ileotransversoanastomosis has been performed. Microscopic investigation of the resected part of the bowel revealed tuberculosis in the terminal ileum and ceacum. The patient was discharged from the hospital without complications on 8th postoperative day.
27. g.davitaia, i.davitaia
A Rare Case of Gastrointestinal Duplication Complicated by Recurrent Profuse Bleedings
J. Experimental and Clinical Medicine, 2012, 4, pp.92-94
TSMU Pediatric Surgery Depart; G.Zhvania Pediatric Clinic, Tbilisi, Georgia
Gastrointestinal duplications (GD) are rare congenital malformations that may vary greatly in presentation, size, location, and symptoms. As well as diagnostic evaluation, surgical approaches are also variable. On the basis of anatomic features tubular, cystic and diverticular forms are differentiated.
Considering rarity and predominantly asymptomatic course of GD, which presents mainly as complication (bleeding etc.) or by means of imaging studies and/or surgical intervention, we report on 1,5 month old patient with cystic duplications of terminal ileum (32cm in length). The case was complicated by recurrent profuse gastrointestinal bleedings.
The case is remarkable for its clinical course, evaluation and surgical approach.
28. I. Dolidze
Role of water in sanogenesis mechanisms
J. Experimental and Clinical Medicine, 2012, 4, pp.95-98
Faculty of Physical Medicine and Rehabilitation; Tbilisi State Medical University, Georgia
Biological life, as it known, is provided by optimal maintenance of complex biochemical and biophysical reactions going on in the cells of organism, in which clean water is the principal factor of preservation of sustainable life of human biosystem. Only clean water may be involved in maintenance of sanogenesis mechanisms of human organism, promoting both preservation of health and reverse development of disease through self-regulation and target allocation of water balance. By the support of the state structures, the overall scientific study of the water factor shall radically change the health problem of the population and extremely reduce the statistic index of morbidity and early mortality.
29. N.Mebonia, T.Qurdaze, T.Avaliani, T.Chkhatarashvili, M.Parulava, K.Kiknadze
Awareness of the population about early detection of cancers
J. Experimental and Clinical Medicine, 2012, 4, pp.98-100
TSMU, Division of Epidemilogy and Biostatistics, Departmnet of Public Health, Tbilisi, Georgia
Cancer morbidity and mortality in the next decades will increase in all regions of the world according to the estimation of the WHO experts. Goal of the study was to estimate the awareness of women in the recommendations of early detection of breast and cervical cancers. Study methods: in two groups of women was conducted cross-sectional study. Randomly were selected study participants among women who had visited Georgian National Screening Center and teachers and parents from the schools located nearby the center. Respondents were interviewed by using standard questionnaire. To estimate differences in the awareness on early detection of cancer between two groups of women was calculated odds ratio and 95% of confidence interval. Study data was processed by using statistical program EpiInfo. Results: Study included 150 participants from the screening center and 120 women selected from the schools. Awareness on the age of the first prophylactic examination of breast in two groups of women were almost the same and low (30% and 27% accordingly, OR=1.0, 95%CI=0.5-1.8); but women from the screening center showed high level of the awareness regarding frequency of breast screening (OR=7.4, 95%CI=4.1-13.6). To the question “when should be started cervical screening”, women from the schools were more likely to give true answers (OR=0.7, 95%CI=0.4-1.2). However, the awareness about the time intervals between preventive examinations of cervix was higher among the women from the screening center. Decisions and Recommendations: About 70% of participants are not aware about recommendations regarding preventive examinations; Should be increased the role of family doctors in improving the awareness of population about early detection of cancer.
30. E.Murvanidze D. Chitashvili
Importance of Parent Instruction in Child Positioning
J. Experimental and Clinical Medicine, 2012, 4, pp.100-102
Ilia State University, Sport Dept, Tbilisi, Georgia
The aim of the research was to teach to the parents right positioning of the child (during dressing, undressing, eating, playing) to keep him/her active during the day, inhibit automatic patterns and maintain improved functional independence.
31. VASHADZE SH.
ARTERIAL HYPERTENSION, THROMBOCYTE AND DEPRESSION
J. Experimental and Clinical Medicine, 2012, 4, pp.103-104
Shota Rustaveli State University, Batumi, Georgia
The aim of the subject is to represents the connection of the Arterial Hypertension & thrombocyte number in blood & to find prevention ways. A clinical case of depression symptoms as outlined in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) is a disorder with both physical and mental characteristics that negatively disrupts an individual's ability to function day to day in social and work environments. We’ve searched for the clinical methods in Batumi Republic Hospital departments.30 patient is studied by us – 15 women & 15 men. Among them, 20 patients were fallen ill with Arterial Hypertension, 5 with Ischemic insult & 5 – with Discirculating Encephalopathy. We’ve the question are of Beck. According to which we were able to ascertain the depression quality. The question are consists of 21 questions; by them it was possible to ascertain depression qualities light, medium & complex. The depression quality was defined s follows: the absence of depression in 13%; mild depression in 17%; medium – 30% and severe in 60%. Thus, Depression quality is very high in people with Arterial Hypertension. The number of thrombocyte is high also. Thrombocytes depression causes significant changes in the function, Thrombocytes Activation, Thrombosis increases the risk. So, it’s necessary to treat this patient with Antithrombotic medicines and Antidepressants. That will contribute to solving the problem.
32. SIKHARULIDZE I., KAKABADZE M., KORDZAIA M., TSILOSANI M.,
KIRVALIDZE I., AMIRANIDZE M.
DEVELOPMENTAL PECULARITIS OF THE FEMALE PELVIS
J. Experimental and Clinical Medicine, 2012, 4, pp.104-106
A. Natishvili Institute of Morphology, Tbilisi, Georgia
We have investigated Georgian women’s features of the female pelvis. In our study we used the pelvis classification of W. Caldwell and H.Moloy (1933) (they selected four types of the pelvis: gynecoid, android, platipeloid and anthropoid). The women recently confined and their new-born children’s characteristics of the physical development were also investigated.
450 practically healthy women at the age of 17-44 were investigated according to the method known as the method of the external pelviometry, adopted in obstetric practice. According to our study the tendency of a contracted pelvis has increased. The pelvis of the gynecoid type had 218 women, pelvis contracted to different extents – 232 women. According to the constitutional type, the pelvis of the gynecoid type had mostly women of the mesosomic constitution, and contracted pelvis – women of the leptosomic constitution. Between the formes contracted pelvis much more of the anthropoid pelvis was evidenced.
33. A. Kotchlamazashvili, T. Kbilashvili
Timely Detection of the Process of Atherosclerosis in Young Generation
J. Experimental and Clinical Medicine, 2012, 4, pp.106-108
Union of Georgia – Foreign Countries Friendship International Society Preventive Cardiologic Room, Ltd “DEKA”, Tbilisi, Georgia
The aim of the above work was to study the violation of lipid metabolism among adults and people of young generation as well. Accordingly, our research was performed in Preventive Cardiologic Roomof“DEKA” Ltd within 2010-2012 years on two groups of age: the first – group of adults from 10 to 24 years including, and the second - the group of young people from 25- up to 30 years old.Upon the whole, the both groups consisted of 28 researched persons were distributed into equal numbers ( accordingly 14 and 14 in each).In the I age group there were not detected high numbers of cholesterin, but instead of it, increasing lipoproteids of law density made up 86%, as for triglycerides are concerned, increasing of their level was showed only in 14%. In the I group high numbers of cholesterin was depicted in 64% of the cases. As for lipoproteids of law density were 86%, as it was shown in the I group; increasing of triglycerides achieved 71%, which is completely reversed, in compare to the first group. So, violation of lipid metabolism in both groups of adults and young generation is expressed in significant amount of cases and all this points to the inevitability of anti-atherosclerosis prevention.
V.ERIASHVILI, N.NEMSITSVERIDZE, S.MGVDELADZE, T.CHUMBURIDZE, N.DUGHASHVILI
PHARMACEUTICAL NATIONAL POLICY AND ESPECIALLY PHARMACEUTICAL MANAGEMENT IN GEORGIA
J. Experimental and Clinical Medicine, 2012, 4, pp.108-110
Department of Social and Clinical Pharmacy, Tbilisi, Georgia
In the process of health reform especially national politic study of pharmacy and related problems will be especially relevant. The aim of this study is to identify and place and the priority of pharmacy in the state, identification of the flexibility of pharmaceutical policy. In order to study the issues raised conducted an anonymous survey of 50 pharmacists in Tbilisi. The result shows that only 22% pharmacists consider pharmacy as a priority sector, 54% say that the pharmaceutical market is monopolized, and 78% believed that the state must control the price of medicines. Based on received data, it can be argued that the Georgian pharmaceutical market is monopolized and that government must create an antimonopoly service, as well as to control the growth of prices for medicines.
35. T.Chumburidze, N.Bokuchava, N.Nemsitsveridze , V.Eriashvili, T.Zarkua
Aspects of pharmaceutical care in Georgia
J. Experimental and Clinical Medicine, 2012, 4, pp.110-112
TSMU Department of Social and Clinical Pharmacy, Tbilisi, Georgia
The aim of this study was to identify people's attitudes toward pharmaceutical care. Try to know how often the patient turns to pharmacist for advice and to obtain information about the selection, administration, dosage, interactions and side-effects of drugs. The survey was conducted; it was found that 73% of respondents visited a pharmacist for advice, while 56% had received pharmaceutical care in selecting drugs and generic substitution. On the basis of the study, it was discovered that the demand for pharmacists, clinicians, in recent years in particular, has increased. It should provide training and retraining of pharmacists into clinical pharmacists, as well as provide legal aspects of clinical pharmacy as a discipline.
36. N.ANTELAVA, M.GHONGHADZE, M.OKUJAVA, K.PACHKORIA, M.GOGOLAURI
METHODS FOR EVALUATION OF EFFECTIVENESS OF HEPATOPROTECTIVE DRUGS
J. Experimental and Clinical Medicine, 2012, 4, pp.113-116
Department of Pharmacology and Pharmacotherapy, Tbilisi State Medical University, Georgia
In the paper are discussed the experimental models of liver injury, induced by hepatotoxic chemicals and medical agents most widely used for domestic reasons and treatment. These models are used for assessment of effectiveness and screening of hepatoprotective drugs. There are described of models acute toxic hepatitis, fibrosis, cirrhosis induced by chemicals: alcohol, CCL4, galactosamine, thioacetamide, and drugs: acetaminophen, antitubercular drugs and Reye’s syndrome is induced by 4-pentenoic acid. The possible mechanisms of hepatotoxicity are discussed as well. This work is important for scientists interested in development of new hepatoprotective drugs.
37. V.Eriashvili, I.Abazadze, T.Tchumburidze, N.Dugashvili, T.Zarqua
PARTICULARITIES OF DRUG REGULATION IN GEORGIA
J. Experimental and Clinical Medicine, 2012, 4, pp.116-119
TSMU Department of social and clinical pharmacy, Tbilisi, Georgia
FIP (federation international of pharmacists) provides recommendations for different aspects of pharmaceutical practice. Implementation of those standards is the way to proper drug regulation. The goal of study is to find out the problems in pharmaceutical sector of Georgia caused by insufficient regulation.
Results of study suggest that legislation is not correspondent of needs of proper drug regulation including Drug and Pharmacy practice Low and antimonopoly regulation.
38. V.Eriashvili, S.Natcvlishvili, N.Dugashvili, T.Zarqua, N.Nemsitsveridze
GSP (GOOD STORAGE PRACTICE) CONDITIONS IN PHARMACEUTICAL ORGANIZATIONS IN GEORGIA
J. Experimental and Clinical Medicine, 2012, 4, pp.119-122
TSMU Department of social and clinical pharmacy, Tbilisi, Georgia
The goal of study was comparison of the conditions of storage practice in Georgian pharmaceutical organizations with FIP (federation international of pharmacists) recommendations concerning GSP
Standards and work out the recommendations for local pharmaceutical sector.
Results of study show that most of local pharmacists are no informed about international standards of GSP sins them are not implemented on governmental level. Our recommendation is Ministry of health, labore and social afares of Georgia to make decision for implementation of national GSP in Georgia.
39. M. NAMORADZE, N. CHELIDZE, K. GAMBASHIDZE, N. BEJITASHVILI,
N. PKHALADZE, M.KATSADZE, N. KIPIANI
ALTERATIONS OF INTENSITY OF LOCAL HEMOCIRCULATION AND MICROHEMOCIRCULATION IN DIFFERENT ORGANS AT DIFFERENT REGIMENS OF HYPERBARIA
J. Experimental and Clinical Medicine, 2012, 4, pp.122-125
Tbilisi State Medical University, Department of Pathophysiology, Georgia
In the presented work, the intensity of local hemocirculation (ILH) in liver and skeletal muscle, arteriolar diameter and microhemocirculation in skeletal muscle and mesenteric arterioles at different regimens of hyperbaria with the use of hyperbaric oxygenation (HBO) has been studied. Experiments were carried out on 60 male mice with the weight range 20-25 g. ILH was studied using H+ clearence method (polarography) providing registration of removal process of electrochemically generated H+ from tissues and valuable information about the state of ILH. Diameter of arterioles was estimated by biomicroscopy.
Investigations have shown that at different regimens of HBO the ILH decreases in skeletal muscle. Intensity of reduction of ILH increases in parallel with increase in hyperbaria/pressure. In contrast, ILH in liver increases. Diameter of arterioles in skeletal muscle decreases in parallel with increase in HBO. Diameter of mesenterial blood vessels decreases also instead of expected dilatation. Supposedly, disorders of hemocirculation at HBO could be caused not only by the compressive effects of hyperbaria, but due to stress hypercatecholaminemia also.
40. Okoev G.G., Arustamyan K.K., Gomcyan G.A.
OPTIMIZACION OF PREGRAVITAR PREPARTION OF WOMEN WITH MISCARRIAGE AND CHRONIC ENDOMETRITIS
J. Experimental and Clinical Medicine, 2012, 4, pp.125-128
Research Centre of Maternal and Child Health Protection, Yerevan, Republic of Armenia
The aim of the study is to optimize the pregravidar preparation of women with miscarriage and chronic endometritis. Magnitotherapy has been included into the complex of pregravidar preparation of 40 women with miscarriage and chronic endometritis.
As a results of complex treatment with magnetotherapy the increase of luteal phase of menstrual cycle, increase of endometrial thickness, increase of the frequency of three linear image of endometrium and decrease of the frequency of ultrasound sings of chronic endometritis have been registered.
41. T.Bakradze, M.Jincharadze, M.Shubitidze
Development of medical touring in Georgia
J. Experimental and Clinical Medicine, 2012, 4, pp.129-130
Tbilisi State Medical University, Public Health Faculty, III course, Tbilisi Georgia
Nowadays in several countries of the world medical service of high quality is connected to great sum. In Georgia the same medical service’s price is more lower. This factor makes suitable situation for medical touring development in our country. It implicates accepting of patients from other countries, treatmen and reabilitationby appling localbiorecources. This writing shortly reproduces the ways of medical touring development in Georgia.
42. I. Kugoti, N. Vepkhvadze
Forecasting of Far-off Results Conditioned by Radiation
for the Population of Some High-mountain Regions of Georgia
J. Experimental and Clinical Medicine, 2012, 4, pp.131-134
TSMU, Department of Preventive Medicine and Environmental Health, Tbilisi, Georgia
Average annual doses of irradiation of the population of some high-mountain regions of Georgia have been estimated in the viewpoint of impact on health, prognostics of far-off results (carcinogenic, genetic) has been carried out and preventive actions have been provided in order to be avoided harmful effects caused due to irradiation.
In the conditions of the impact of existing irradiation doses, 17, 5 and 8 of cancer and 0,7; 0,2 and 0,3 complementary events of genetic defects are expected accordingly in Mtskheta-Mtianeti, Racha-Lechkhumi and Kvemo Svaneti regions and mountainous district of Adjara.
Definition of the level of radon in buildings and carrying out of measures for reducing it in case of need has great importance in order to be reduced the dose of irradiation of population. Reduction of irradiation caused by artificial sources, especially by medical X-ray diagnostic procedures, is important as well that implies avoidance of non-necessary examinations and utilization of alternative, non-ionizing methods of examination for specifying diagnosis.