J. EXPERIMENTAL & CLINICAL MEDICINE
2013, ¹ 2
1. Kh.Rekhviashvili, I.Pantsulaia, N.Jakhutashvili, M.Iobadze, N.Pantsulaia, N.Kikodze, N.Bikashvili, D.Metreveli, T.Chikovani
CD4+CD25+ T Regulatory Cells in Pathogenesis of Diabetes Type 1
J. Experimental and Clinical Medicine, 2013, 2, pp.11-16
Tbilisi State Medical University, Medical Institute of Biotechnology, Tbilisi, Georgia
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease resulting in islet b cell destruction, hypoinsulinemia, and severely altered glucose homeostasis. Auto-reactive effector T cells as well as TH1/Th2/Th17 cytokines balance are controlled by regulatory T cells (Tregs). A failure of Tregs plays a critical role in the development of T1D.
The main goal of our research was to study the role of CD4+CD25+ Tregs in T1D in the regarding the disease duration. We determined CD4+CD25+ Tregs isolated from peripheral blood in a cohort of healthy individuals and individuals with T1D at the department of Endocrinology of the Tbilisi State Medical University and Diabetic Children Association. Patients were divided into 3 groups, according to the disease duration. CD4+CD25+ cells were isolated from the mononuclear cell fraction using CD4+CD25+ positive cell selection kit (MagCellect magnet R&D; MiniMacs, Germany). CD4+CD25+ Tregs were immunophenotyped by method of flow cytometry (BD FACSCalibur flow cytometer, USA). It was shown that in patients with T1D quantity of CD4CD25TOT cells did not correlate with the disease duration, wheareas quantity of CD25high cells were insignificantly increased after 20 years.
2.Maximov S., Gatenadze C., Chomakhasvili Z., Zosidze N.
Exenteration pelvic organs in patients with cancer of the cervix
J. Experimental and Clinical Medicine, 2013, 2, pp.16-19
Batumi Shota Rustaveli State University, Georgia
In article in details are described the results of surgical treatment of nineteen patients, on this basis formed the indications and contraindications of exenteration, which consists in next: dissemination of the tumor in the abdominal cavity, distant tumor metastasis, metastastases in the pelvic lymph nodules, triad of symptoms (lymphedema of the lower limbs, uretral obstruction, pelvic pain), which indicates tumor invasion into the pelvic wall, negative psychosocial aspects of life. Conditions conducive to the successful operation can be summarized as follows: selection of patients to identify between them potentially readiness of the patient for surgery, well-crafted surgical approach and intensive post-operative care for a sick.
3. Didebulidze N., Kakabadze M., Gordadze N.
Effect of growth hormone on the change in concentration of androgen receptors in the liver of male rats with alloxan diabetes
J. Experimental and Clinical Medicine, 2013, 2, pp.19-23
A.Natishvili Insitute of Morphology, Department Of Anatomy, Topographic Anatomy And Operative Surgery, Javakhishvili Tbilisi State University
Data obtained revealed that the development of alloxan diabetes is accompanied by changes in somatotrophic function of pituitary and increase of liver tissues sensitivity to androgenes. Increase of GH concentration in serum of experimental animals was correlated with the concentration of blood glucose and the severity of pathological changes. Analysis of AR content in the liver of experimental animals according to GH concentration in the serum revealed that low concentrations of GH stimulates, and large -inhibits androgen receptor proteins.
4. Ukleba K., UGREKHELIDZE Z., Chakvetadze T.
Medical Observation of Pregnant Women with in the Primary Healthcare System
J. Experimental and Clinical Medicine, 2013, 2, pp.23-27
Akaki Tsereteli State University, Medical Faculty, Kutaisi, Georgia
The objective of this research is to improve Medical Observation of Pregnant Women within the Primary Healthcare System.This research paper was based on the audit of medical observation of pregnant women conducted at Kutaisi family medical center. We studied the medical maps of 85 pregnant women from 20 to 40 age.
After reviewing the results of the above mentioned audit we can make a conclusion that the quality of medical observation of pregnant women requires improvement for which the following measures need to be taken: The patient needs to be informed about healthy nutrition, rest time, medical exercises that will help them effectively manage pregnancy period in order to reach maximum level of relaxation. Information about healthy life styles need to be included in the medical documentation. Considering the importance of timely diagnoses of Gestational Diabetes, it is important to obtain funding in order to define the level of plasmatic glucoses in blood during the II visit as defined by the standard.
It should be noted that pregnant women are regularly checked in 100% of cases in order to reveal anemia (I and III visits); Arterial Hypertension (every visit), Sexually Transmitted Infections (I and IV visits).
27. Kochakidze N., Mdivani N., Khetsuriani R., Shukakidze A., Kipiani T.
ABERRATION GENOMS HAVING PEOPLE’S REHABILITATIONS SOME ASPECTS
J. Experimental and Clinical Medicine, 2013, 2, pp.27-30
TSMU Departament of Human Aanatomy, Tbilisi, Georgia
Rehabilitation influences of adaptive physical exercises are based on interrelation of impellent and vegetative functions. In particular, at corrective picked up physical exercises, according to functionalities of an organism, muscular activity causes positive changes in work of internal bodies.
Received data from researching and control group, allows conclude, that the complex adaptive exercises and correct by selected power of physical load, with the accounting of time, cause comparative rehabilitation cardio-system for people with congenital aberration of genes, which is very important for their vital activity, from our point of view.
6. Todua L., Nikuradze N ., Jorjikashvili L.
The Contact Lenses and Oncology Diseases of the Eye Front Segment
J. Experimental and Clinical Medicine, 2013, 2, pp.30-33
Department of Ophthalmology, Tbilisi State Medical University, Georgia
The clinical picture of the oncology pathological picture of the eye front segment have been described when wearing of optical and cosmetic lenses is hazardous and contraindicated, and tactics of a physician-ophthalmologist in case of exposure of oncological processes.
7. CHITASHVILI D.M., KORINTELI E.N.
The functional parameters of athletes depending on geography of competition
J. Experimental and Clinical Medicine, 2013, 2, pp.33-36
Ilya State University, Tbilisi State Medical University, Georgia
In the article the changes are described of heart and breathing system of the elite sportsmen in the process of competitions, which were held in different latitude and longitude of the world. Date, presented on the article, enables a coach to make adequate correction before starting a competition.
8. Davarashvili Kh. T., Dgebuadze M. A., Kvachadze T. I., Tsagareli Z. G.,
Korsantia N. B., Zhvitiashvili T. O.
Structural changes of the capillary wall and ground amorphous substence in the dental pulp under the different clinical and morphological forms of chronic pulpitis
J. Experimental and Clinical Medicine, 2013, 2, pp.36-40
Iv. Javakhishvili Tbilisi State University, A.Natishvili Institute of Morphology.; Tbilisi State Medical University, Department of Odontology, Tbilisi, Georgia
The purpose of the study is to examine the ultrastructural features of the capillary endothelium and the components of the pulp ground substance with chronic fibrous and gangrenous pulpitis.
It was established that at chronic fibrous pulpitis there are structural changes characteristic for fibroplastic processes, becouse the chronic inflammatory infiltrate contains not only fibroblast like cells but the large amounts of lymphoid and plasmocy te cells.
Thus, both clinical and morphological forms of chronic pulpitis characterized by the arising the pulp ground substance dencity, neoangiogenesis and aggregation of collagen bundeles deposits that change the pulp typical anatomical structure and create conditions for the hypothrophy and false denticle formation.
9. Sakandelidze R., Lomsianidze I., Shalamberidze A.
The Relations of Endogenous and Exogenous Circadian Rhythms Organizing the Body Biorhythms and Their Importance for Emotional Behaviour of the Anxiety
J. Experimental and Clinical Medicine, 2013, 2, pp.40-43
Akaki Tsereteli State University. Kutaisi. Georgia
Accurate, coordinated action of the vital processes of the body is mainly conditioned by the biological rhythms that have a changeable character which alters according to the circadian rhythms and inner biological factors of the body. One of such internal factors is melatonin – the hormone of epiphyseal origin. Regardless the degree of the activity characteristic to a living organism, the highest level of melatonin is released only at night.
In order to study the abovementioned occurrence the experiment was conducted on Wistar rats. A twenty four our day-night cycles were artificially created. By means of pharmacological substances the level of melatonin was changed in the desired direction. For this purpose step-through and punished drinking tests were applied.
It was concluded that the quantitative increase of melatonin is modified according to the reduction of anxiety-related behaviour and vice versa. Otherwise, the adaptive system of the body is destroyed and results in poor health.
10. Chuyko M.N.
Trends of the frequency of intraventricular hemorrhage in preterm infants of the Lviv city during the 2005-2011 years
J. Experimental and Clinical Medicine, 2013, 2, pp.43-49
Danylo Galytsky Lvov National Medical University, Department of Postgraduate Education,
Chear of Pediatrics and Neonatology, Ukraine
In a retrospective cohort study in which involved 665 preterm infants with a gestational age of 27-35 weeks in 2005-2011 years identified the incidence of intraventricular hemorrhage in the perinatal period and survival in the neonatal period. Determined the frequency of intraventricular hemorrhage of varying severity in preterm three subgroups: with gestational age less than 28 weeks (n = 119, 18.1%), subgroup A, children with gestational age more than 28 weeks and less than 32 weeks (n = 165, 25, 1%), subgroup B, children with gestational age greater than 32 weeks and less than 35 weeks, subgroup C (n = 371, 56.4%). Found that the incidence of intraventricular hemorrhage in the perinatal period for the 2005-2011 years was 40,5%. Survival rates of premature bleeding reached 85,95%. The most vulnerable children to the emergence of intraventricular hemorrhage were infants with gestational age 27-32 weeks, with a significant prevalence of severe hemorrhage and fatal conclusion among these infants. Changing approaches to health care preterm infants, actively took place since 2006, according to the order Ministry of Health of Ukraine reduced the incidence of intraventricular hemorrhage in the study cohort of children in 2011 year to 18% in comparison with 2007 year.
11. GOGEBASHVILI N., JASHI L., MACHAVARIANI M., ENUKIDZE M.
IMMUNOMODULATING EFFECTS OF PHENOVINE AND UNO DT GATO IN CELL CULTURES
J. Experimental and Clinical Medicine, 2013, 2, pp.49-51
Tbilisi State Medical University, Georgia
The present article deals with immunomodulatory, proliferation stimulatory effect of phenovin and Una de Gato on culture of in vitro Jurkat cells. Viability of Jurkat cells after incubation period with phenovin using MTT test according to standard methodology.
It was established that phenovin is characterized by well expressed immunomodulatory effect revealed by by increased viability of Jurkat cells. Una de Gato increases the effectivines of phenovin.
12. Chikviladze D., Gachechiladze Kh., Miqeladze M., Matreveli D., Zedgenidze Y.
Microbial structure of hospital infections
J. Experimental and Clinical Medicine, 2013, 2, pp.51-54
Tbilisi State Medical University, Department of Microbiology and Immunology. Georgia
The article presents the bacteriologic research results conducted in the last ten years. Studies were carried out on surgical patients with different infections in various surgical hospitals in Tbilisi. Total 1947 microbial strains were isolated. The most common cause of hospital infections are; Pseudomonas aeruginosa, Proteus spp., Staphylococcus aureus, and E.coli. Frequency of isolated gram-negative micro flora was 1,7 times more than gram-positive.
13. Saakashvili N.M., Chilingarishvili T.G., Jakobia N.V.
OUTLOOKS OF RECREATIONAL TOURISM DEVELOPING IN SAMTSKHE-
J. Experimental and Clinical Medicine, 2013, 2, pp.54-56
Tbilisi Balneology Resort-Tbilisi-SPA, National Scientific- Practical Center Of Health And Medical Rehabilitation. Tbilisi, Georgia
Georgia is a country of health resorts. there are 103 resorts, about 400 resort places, over 2 000 mineral springs, the daily flow of which makes up 130 million liters, medical mud deposits, sea and mountain climatic resorts, spa resorts.
South Georgia, Samtskhe –Javakheti region is very rich with its historical monuments and health resorts. Here are located 15 health resorts and 13 resort places. Borjomi is the most popular spa resort of Georgia since XIX century. The major natural curative factors are acidulous, hydrocarbonate, sodium (VISHY’S TYPE) mineral waters, which are used as a curative drink, for medical baths, inhalation, lavage of stomach and intestine. They are used as a curative and table- drink bottled, outside the resort and are spread in many countries of the world.
A wonderful 3 Km walk from the park leads you through wild forest to a warm, steaming sulfur spring with two pools – the larger for adults and smaller for the children. These are thermal sulphide mineral waters, which are also considered to be highly effective for treatment of rheumatic, locomotor system diseases, problems with the peripheral nervous system, skin disorders and other ailments by means of medical bath (spa- therapy).
14. MIRVELASHVILI E., KIKACHEISHVILI E., DZAGNIDZE M., DEDABRISHVILI A., KVIZHINADZE N.
Lower respiratory tract infections epidemiological characteristics of bacteriological studies
J. Experimental and Clinical Medicine, 2013, 2, pp.56-60
In 2008-2012 years was studied 378 patients. In etiologic structure prevailed K.pneumoniae-73,5%, C.albicans-62,5%, S.aureus-42,3%, Ps.aeruginosa-33,4%, Acinetobaqter spp-27,2%. In associations were mainly revealed Pseudomonas (Ralstonia) pickettii+C.albicans+N.sicca+N.mucosa-25%, S.aureus+ Ps.aeruginosa-50%.
According to the obtained data real picture of microecology of upper respiratory tracts became visible. Investigations were carried out using modern standart technology of French firm BioMerieux.
15. Topuria D., Matoshvili M., Topuria I., Kvizhinadze N., Kanteladze N.,
Amiranashvili I., Chutkerashvili K.
Cells that are Contributing in Regeneration of the Damaged Liver
J. Experimental and Clinical Medicine, 2013, 2, pp.60-63
Tbilisi State Medical University, Human Normal Anatomy Department, Dermato-Venerology Department; O. Gudushauri National Medical Center, Tbilisi, Georgia
Liver regeneration restores the original functionality of hepatocytes and cholangiocytes in response to injury. In response to injury, mature hepatocytes have the capability to proliferate and give rise to new hepatocytes and cholangiocytes. Meanwhile, liver precursor cells (oval cells) have become the most recognized bipotential precursor cells in the damaged liver. They rapidly proliferate, change their cellular composition, and differentiate into hepatocytes and cholangiocytes to compensate for the cellular loss and maintain liver homeostasis.
16. Gambashidze K.G., Khorava P.A., Bejitashvili N.D., Pkhaladze N.G.,
Azaladze T.N., Lasareishvili B.G., Azaladze A.T., Jaiani E.G., Tediashvili M.I.
Investigation of efficacy of anti-tumor preventive vaccinations with the use of bacterial phagelysates in experimental studies
J. Experimental and Clinical Medicine, 2013, 2, pp.63-66
Tbilisi State Medical University; G.Eliava Institute of Bacteriophage, Microbiology and Virology, Tbilisi, Georgia
We were aimed to investigate anti-tumor preventive potential of E. coli pagelysate vaccinations in experiment. Investigations were carried out on 2-3 months 48 male mice. Regimen of preventive vaccinations were: single - 0,25 ml E.coli phagelysate intraperitoneal injection, 3 days before Ehrlich carcinoma inoculation (1x106 tumor cells), and 3 times vaccinations - 0,25 ml E.coli phagelysate injections with 5 day intervals, 3, 6, and 9 days before inoculation of carcinoma. Treatment efficacy was evaluated according to the indices of cancer growth (development of cancer tissue, cancer growth inhibition percent, lifespan and survival percent). Results were analyzed statistically with the use of SPSS 16.0 for Windows. Experiments have shown that single and 3 times preventive E.coli phagelysate vaccinations are well tolerated in mice and do not stimulate malignant growth.
Vaccinations inhibited tumor development and delayed the malignant growth. Cancer growth inhibition percent in vaccinated animals were 55% on the average. Maximal lifespan in control group mice consisted 59 days. By the 125th day of cancer growth, at single preventive vaccination, the 17% of mice were alive, while in 3 times vaccinated mice, the survival percent was 25%. Anti-tumor potential of E.coli pagelysate supposedly could be explained by immunoregulatory properties of preparation.
16. ZUBITASHVILI G.
J. Experimental and Clinical Medicine, 2013, 2, pp.63-66
Ilia State University, College of Arts and Sciences, Tbilisi, Georgia
In the article it is discussed how important it is to take care for hygienic demands during the sporting activity. The recommendations are given that should be taken into consideration and practically fulfilled, that in term is a guarantee for one’s health maintenance and, the `condition` for achieving the highest sports results.
17. MATOSHVILI M., RICHETTA A., KATSITADZE A., TOPURIA D.,
MATOSHVILI N., TOPURIA I.
THE PREVALENCE OF HYPERTENSION IN GEORGIAN PSORIATIC PATIENTS
J. Experimental and Clinical Medicine, 2013, 2, pp.66-69
Department of Dermato-venereology, HumanNormalAnatomy Department,Tblisi State Medical University; O. Gudushauri National Medical Center, Tbilisi, Georgia; "La Sapienza" University of Rome; Department of Internal Medicine and Medical Specialties Rome, Italy
Psoriasis is one of the most important chronic skin diseases. Several studies state that patient with psoriasis carry an increased risk of metabolic syndrome, which includes arterial hypertension, but some studies did not demonstrate this association. The aim of our study was to investigate the prevalence of hypertension in Georgian psoriatic patients.We performed a hospital-based case–control study on 140 psoriatic patients and 140 patients with skin diseases other than psoriasis, matched by gender and age.The results of this study support the association between psoriasis and hypertension.The prevalence of hypertension was signiﬁcantly higher in psoriasis patients than in a control group (36.4%, 27.9%, P < 0.001).
19. D. TOPURIA, M. MATOSHVILI, I. TOPURIA, N. MATOSHVILI
THE ROLE OF CELLULAR THERAPY IN LIVER DAMAGE TREATMENT
J. Experimental and Clinical Medicine, 2013, 2, pp.72-75
Tbilisi State Medical University, Human Normal Anatomy Department&Dermato-venerology Department, O. Gudushauri National Medical Center, Tbilisi, Georgia
In most cases, due of liver,s unique ability to regenerate, it,s function will return in stabilize form if the offending chemical is stopped early. Additionally, the patient may require supportive treatment. Hepatic stem/progenitor cells also known as “oval cells” in have been implicated in liver tissue reparative regeneration, Authors present method of preparing has antihepatocytotoxic serum from progenitor cells, it,s influence on reparative regeneration process in damaged liver cells.
20. KOBIDZE T., BEJANISHVILI M., GURESHIDZE B., LOBJANIDZE N., TOPURIA D.,
KURDADZE E., CHAVCHANIDZE N., GIORGOBIANI T.
CLINICAL CASE OF ORGANOPHOSPHATE POISONING – “INTERMEDIATE SYNDROME” (IMS)
J. Experimental and Clinical Medicine, 2013, 2, pp.75-78
Clinical Toxicology Section, Department of Critical Medicine, Tbilisi State Medical University, Tbilisi, Georgia
Acute poisonings are properly attributed to particularly dangerous disorders. Broad-spectrum highly effective systemic insectoacaricide known as BI-58 is characterized with especially high toxicity. In organophosphate poisoning, particularly in severe cases, a so-called “Intermediate Syndrome” (IMS) may develop within 24-96 hours. This may be caused by prolonged action of acetylcholine and development of tolerance in cholinergic receptors. In the report the complex of symptoms of the patient with organophosphate poisoning is given with the description of IMS. The effectiveness of pathogenetic treatment of IMS is also demonstrated.
21. TSINTSKALADZE G., ZAUTASHVILI M., EPRIKASHVILI L., SHARASHENIDZE T., BURKIASHVILI N., BURDZHANADZE M.
POSSIBILITY OF USE OF NEW ZEOLITE MATERIALS IN MAXILLOFACIAL SURGERY
J. Experimental and Clinical Medicine, 2013, 2, pp.78-81
Ivane Javachishvili Tbilisi State University, Petre Melikishvili Institute of Physical and Organic Chemistry, Tbilisi, Georgia
Clinoptilolite, natural zeolites located in Georgia, enriched by phosphorus and calcium has been studied. Investigations on the rabbits shows the possibility of use of this materials in medical practice for treatment of osteomyelitis, odontogenic cyst, for completion of defects of jaw bones.
22. T. NOZADZE, T. KATSITADZE
DAMAGE OF EXTERNAL ILIAC ARTERY AFTER TOTAL HIP REPLACEMENT.
J. Experimental and Clinical Medicine, 2013, 2, pp.81-86
Department of Orthopedic and trauma surgery, Tbilisi State Medical University, Georgia
Twenty four cases of external iliac artery damage have been described since year
With the recent increase in total hip replacement procedures we can observe concomitant increase of intra- and postoperative complications. At this time we will focus our attention on one rare complication – damage of external iliac artery.
At our department we had several cases of complication mentioned above. In one case patient was diagnosed with pseudo aneurysm of external iliac artery. In another case patient was diagnosed with protrusion of acetabular component 4,5 years later after initial surgery, this patient was also diagnosed having pseudo aneurysm. In one case of purulent process external iliac artery was accidentally injured with retractor during surgery.
Concerning the data from analysis of cases mentioned above, it is necessary to preserve principle of minimally invasive surgery, vascular anomaly has to be foreseen in the cases with hip dysplasia, careful postoperative monitoring of patient is a must and in the case of postoperative complications contrast-angiography must be used.
23. A.I. KOTCHLAMAZASHVILI, T.O. KBILASHVILI
THE PART OF COMBINED ANTIOXIDANT THERAPY IN PREVENTION OF ATHEROSCLEROSIS
J. Experimental and Clinical Medicine, 2013, 2, pp.86-88
Union of Georgia-Foreign Countries Friendship International Society Preventive Cardiologic Room, Tbilisi, Georgia
The survey was conducted in 100 patients (92 men, 8 women) divided into two equal groups. I group (50-46 men, 4 women) was held combined antioxidant therapy (30mg. Polish Coenzyme Q10, 60mg. American Ginkgo Biloba, 200mg. French Fresh Royal Jelly and 405 mg. American Wild yam the same Dioscorea) for the regulation of lipid metabolism and prevention of repeated infarction in therapeutic doses. The one-month course of treatment lasted for four years seasonally. Combined antioxidant treatmentwas notcarried outin II Control group.
As a result of the mentioned treatment the increased total cholesterol was regulated within normal limits in 35 patients (70%), Triglycerides – in 30 patients (60%), Low-density cholesterol – in 25 patients (50%), stenocardial pains were removed in 40 patients (80%), and they were alleviated in 10 patients (20%). During the four years even a single case of repeated infarction was not observed in I group, while the case of repeated infarction was detected in 5 patients (10%) in II control group during the first four years (two large-focal and three small-focal infarction).
24. Z. KATSITADZE, M. ABESADZE, A. SHUKAKIDZE, T. KHOMERIKI
CHARACTERISTICS OF BLOOD VESSEL DISTRIBUTION WITHIN THE GREATER OMENTUM
J. Experimental and Clinical Medicine, 2013, 2, pp.88-91
Tbilisi State Medical University, Department of Human Anatomy, Georgia
Greater omentum, as an organ, is of significant importance in abdominal surgery. It is frequently operated on during traumatic abdominal injuries, resection of malignancies, plastic surgeries etc.
We took into consideration the fact that its clinical anatomy has not been explored well enough and designed a research study to look at the macro and micro angioarchitectonics of the greater omentum.
25. I.TARKHAN-MOURAVI, N.KAKULIA, I.KVINIKADZE, N.KVINIKADZE
ELECTROPHORESIS OF A TRACE ELEMENT SELENIUM - AN EFFECTIVE METHOD OF TREATMENT OF PATIENTS WITH ESSENTIAL HYPERTENSION
J. Experimental and Clinical Medicine, 2013, 2, pp.91-93
Tbilisi State Medical University. Department of Balneology and Medical Tourism. Tbilisi Balneology Resort “Tbilsi –SPA” National scientific and practical center of health and rehabilitation, Georgia
It is established that treatment by an electrophoresis of a Trace Element Selenium is an effective method of therapy of essential hypertension; causes in patients with essential hypertension decrease in arterial pressure and improvement of indicators of cardial haemodynamics, normalization of a clinical condition and indicators of a lipidic metabolism, increase of oxygen providing an organism, and increases tolerance to physical activities.
26. N.KHOTENASVILI, L.AKHMETELI, L.SAGINASHVILI, G.MERABISHVILI
PHAGOTHERAPY in complex treatment of chronic anal fissure
J. Experimental and Clinical Medicine, 2013, 2, pp.93-96
147 patients underwent the surgical therapy of chronic anal fissure. 70 out of them in the post operational period along with traditional treatment method underwent the local phagotherapy. We have compared the clinical surveillance and laboratory researches and came to the conclusion that use of the phagotherapy for the chronic anal fissure therapy in the post-operation period is purposeful concerning shortening terms of the therapy length and number of complications; this in its turn will decrease the economic expenses for the therapy.
27. M.TORTLADZE, N.KINTRAIA, T.SANIKIDZE
ROLE OF CALCIUM IONS IN THE PATHOGENESIS OF PREECLAMPSIA
J. Experimental and Clinical Medicine, 2013, 2, pp.96-98
TSMU Dept of Obstetric and Ginecology; Dept of Biophisics, Tbilisi, Georgia
The aim of the study was to establish the role of disorders of calcium Ca2+ions content in the pathogenesis of preeclampsia.
The research was conducted on pregnant women with physiologic pregnancy (30 patients) and with preeclampsia (50 patients). In the group of preeclampsia were included women who in the third trimester of pregnancy revealed hypertension and concomitant proteinuria.
A reduction in the levels of progesterone and Ca2+ ions in the blood of the patients with pre-eclampsia at the end of 2-3 trimester was detected. It is concluded that the lack of progesterone in pre-eclampsia is one of the causes of impaired calcium homeostasis, the reactivity of blood vessels and the development of hypertension.
28. M. Shengelia, T. Sanikidze , M. Giorgobiani, N. Gogebashvili
Lipid profil and Gallstones composition in Women during Menopause
J. Experimental and Clinical Medicine, 2013, 2, pp.98-102
Tbilisi State Medical University, LTD ”1st Clinic”, Tbilisi, Georgia
Results showed a significant elevation in both HDL, LDL and total cholesterol in the patients blood with gallstones when compared with controls (without gallstones). The triglycerides in serum in the gallstones patients were not altered. In patients gallstones a cholesterol content was higher than 70% of the dry weight and were therefore considered as having cholesterol gallstones. It was found positive correlation between blood plasma and gallstones cholesterol content, and negative correlation between blood estradiol level and cholesterol content in gallstones.
The results of the present study demonstrated the pathophysiological significance of alterations of hormonal homeostasis during menopause in the pathogenesis of cholesterol gallstone formation.
29. M. NIKOLAISHVILI, G. IORDANISHVILI, T. MUSELIANI, G. JIKIA, S. ZenaISHVILI,
INVESTIGATION OF NEURO–MOTIVATION BEHAVIOR AND NEUROCHEMICAL CORRELATES IN WHITE AND BLACK RATS IN PHYSIOLOGICAL NORM AND IRRADIATION CONDITIONS
J. Experimental and Clinical Medicine, 2013, 2, pp.102-104
Beritashvili Biomedical Center, Tbilisi, Georgia
Biogenic amines and SH–radicals quantitative metabolism in white and black rats are different and this difference is statistically proved. Particularly serotonin quantity and albumine and non–albumine sulfhydric groups content in black rats are higher than in white rats that appears in their radioresistance. Also should be mentioned that effect of black rat’s radioresistance is expressed in melatonin quantity. In some time after irradiation they loose black colour, slowly become grey and in last die.
30. M.NIKOLAISHVILI, M.GOGUA, Q.FRANCHUKI, T.TUFINASHVILI, I.VASHAKIDZE
SAFERAVI BREED GRAPE SEED OIL INFLUENCE ON CURE OF PERIODONTITIS
J. Experimental and Clinical Medicine, 2013, 2, pp.104-106
David Aghmashenebeli university of Georgia, Biomedicine centre of Beritashvili, Tbilisi
Oil extracted from Saferavi breed grape seeds by cold pressure in case of periodontitis, causes normalization of oral cavity enzymes action, inhibition of oral cavity inflammatory processes and at last their suppression. Exactly unique properties of oil became cure initiating and periodontitis starting stage stopping agent.
31. G.PARKOSADZE, M.SULAKVELIDZE, T.SANIKIDZE
PATHOGENETIC ROLE OF LIPID METABOLISM IN NON-ALCOHOLIC FATTY LIVER DISEASE
J. Experimental and Clinical Medicine, 2013, 2, pp.106-109
Tbilisi State Medical University, Georgia
The aim of the study was determination the possible pathogenetic connection. between estrogen deficiency and development of dislipidemia and non-alcoholic fatty liver disease in postmenopausal women.
The results of the study revealed that physiological estrogen deficiency at the age of menopausa induces disorders in lipid metabolism (blood mslp - a decrease of LDL-cholesterol and increase of triglycerides concentration in blood) phenotypic for metabolic syndrome, which are related with elevation of atherogenic index Tg/HDL. We can conclude that the lack of estrogen induces development of metabolic disorders, which in turn are associated with a higher risk of developing metabolic syndrome and hepatosteatosis inmenopausal woman.
32. A. ISAKADZE, M. NONIASHVILI, I. GANUGRAVA
THE EFFICIENCY OF STEPWISE LONG-TERM PREVENTIVE MEDICATION WITH ANTIHYPERTENSIVE AGENTS
J. Experimental and Clinical Medicine, 2013, 2, pp.109-113
The Science Academy Preventive Medicine of Georgia,TSMU Department of Therapy, Tbilisi, Georgia
Data on the efficiency of stepwise long-term preventive medication with antihypertensive agents are presented. The stepwise regimen of antihypertensive medication produced at least a short-term hypotensive effect (more than 1 month) in 93,5% of patients within 1 year, with complete arterial BP normalization in 67,7% and partial effect in another 25,8%. Stable effect (more than 6 months) was however achieved in 1|5 of patients only. Side effects associated with this regimen were seen in 19,4% of patients. Since the effect persisted for more than 2 months in 52,6% of patients only, and was only stable (over 6 months) in on fifth, follow-up elaminations of patients with arterial hypertension should be made at least once a month to allow assessment of the efficiency and safety of medication.
33. A.Isakadze, M. Noniashvili, N. Burkadze, I. Ganugrava
THE ABDOMINOCARDIAL SYNDROME. DETECTION AND TREATMENT AT THE PREHOSPITAL STAGE
J. Experimental and Clinical Medicine, 2013, 2, pp. 113-115
The Science Academy Preventive Medicine of Georgia; TSMU Departament of Therapy, Tbilisi, Georgia
The aim of our study describes the results of examining 120 patients with chronic recurrent pancreatitis, 110 patients with chronic non-calculous cholecystitis and 70 patients with duodenal ulcer to detect the abdominocardial syndrome (ACS). Shows the rate and the most characteristie complaints of patients with the indicated syndrome, gives the detailed characterization of the main clinical manifestations of the ACS. Provides the data on microcirculation and ECG studies at the polyclinical stage and results of studying myocardial contractility, peripheral hemodynamics and immunological parameters under inpatient conditions. Notes the greatest degree of changes among patients with chronis pancreatitis and cholecystitis associated with the ACS.
34. E. Murvanidze D. ChitaShvili
Characteristics of Cerebral Palsy Spastic Diplegic Forms
J. Experimental and Clinical Medicine, 2013, 2, pp.115-117
The research was aimed at the analysis of cerebral palsy spastic diplegic forms among children and youngsters and on development of principles of treatment on the basis of it.
35. L. SAGINASHVILI, L. AKHMETELI, L. DZNELADZE, N. KHOTENASHVILI
MESENTERIC CYSTS’ COMPLICATIONS
J. Experimental and Clinical Medicine, 2013, 2, pp.117-119
Department of Surgery ¹1 of the Tbilisi State Medical University, Division of Surgical Diseases, Georgia
The mesenteric cyst (MC) is one of the rarest abdominal tumors. Since the first report of a mesenteric neoplasm by Italian anatomist Benevieni in 1907, only about 820 cases have been reported. The precise cause of mesenteric cysts is unclear. They have been reported from the duodenal to the rectal mesentery but are most commonly located in the ileac mesentery. MC can be discovered as an incidental finding by routine abdominal examination or during laparotomy for another condition. Mesenteric cysts may cause diagnostic problems because clinical symptoms are misleading or uncharacteristic even if the tumor is large.
Our case-report involves a 45 years old woman who was admitted to the emergency service in a heavy condition with acute diffuse peritonitis. Emergency laparotomy revealed that the cause of peritonitis was a ruptured, infected partly necrotic cyst located in the mesentery of the transversal colon.
Although mesenteric cysts are rare and generally asymptomatic, these tumors can become quite large, may complicate and cause acute abdominal problems. The rarity of this tumor and lack of clinical manifestations make a pre-surgical diagnosis extremely difficult or even impossible.
36. M. Natidze, L. Makaradze
Results of the accelerated agglutination method for diagnosis of brucellosis
J. Experimental and Clinical Medicine, 2013, 2, pp.119-122
Georgian Agrarian University, LTD “Immunogen” Tbilisi,Georgia
Rapid diagnosis of brucellosis is a base of fast identification of diseased animals and preventive measures.
Mainly, diagnosis of brucellosis is provided by serologic reactions (agglutination test, Roz-bengal test, milk reaction and concurrent immune ferment assay). Diagnostic reagents are imported from abroad.
We have developed fast agglutination reaction method, using locally produced color antigen and makes possible large stock check for brucellosis during their lifetime. Diagnosis is given in 4-5 minutes. Reaction is highly sensitive and specific.
37. S. MGEBRISHVILI , I. BARBAKADZE
TREATMENT OF PARTIAL ADENTIA DURING ABNORMAL POSITION OF THE THIRD MOLAR
J. Experimental and Clinical Medicine, 2013, 2, pp.122-124
University Dental Clinic of TSMU ¹1; TSMU Direction of clinical prosthetic dentistry, Tbilisi, Georgia
We made clasp dental prosthesis, which was composed of the metal frame, plastic basis and artificial teeth, though differed from the classic clasp dental prosthesis - in the area of atypically standing tooth it had a clammer, vestibular part of which was made according to method of casting and in the main fulfilled a support function and the oral part was made from elastic metal clammer, owing to this it became convenient to adapt clasp dental prosthesis in the mouth cavity, also was provided its stability in various phases of masticatory act and speech.
38. S. MGEBRISHVILI , V. GURBANOV, I. BARBAKADZE
MODIFICATION OF IMPRESSION TRAY FOR PRODUCTION OF CERAMIC-METAL BRIDGE PROSTHESIS
J. Experimental and Clinical Medicine, 2013, 2, pp.124-126
University Dental Clinic of TSMU ¹1; Direction of clinical prosthetic dentistry, Tbilisi, Georgia
Modification of impression tray suggested by us as compared with the standard impression tray is characterized by the advantage that after placement of silicon impression mass on it, it is possible in one moment to take as the desired impression of the maxillary dental arch and at the same time determine bite in the state of central occlusion (possibility of this is given by the fact that a tray does not have an occlusal surface), and occlusal surface of the impression tray provides simultaneous withdrawal of the impression and bite from the mouth cavity without any deformation. By means of the mentioned impression tray it is possible to take impression using as silicon so alginate impression masses.
39. S. MGEBRISHVILI , Z. NAKUDASHVILI , I. BARBAKADZE
METHOD OF INDIVIDUAL IMPRESSION TRAY PRODUCTION DURING TREATMENT OF SECONDARY PARTIAL ADENTIA
J. Experimental and Clinical Medicine, 2013, 2, pp.126-128
University Dental Clinic ¹1 of TSMU; Direction of clinical prosthetic dentistry, Tbilisi, Georgia
During production of partial denture lamellar prosthesis or clasp dental prosthesis we give preference to taking of impression using individual impression trays. Partial denture lamellar prosthesis or clasp dental prosthesis produced on the models casted on the impressions taken by the impression trays are characterized by more accuracy, are tightly placed on the prosthesis field and owing to this food debris does not get under prosthesis basis and seldom require correction.
40. KH. POCHKHUA, SH. KHETSURIANI, M. CHITALADZE, K. KHETSURIANI, L. GABUNIA
BIOLOGICAL CHARACTERISTICS OF STAPHYLOCOCCUS AUREUS MULTIRESISTANT STRAINS
J. Experimental and Clinical Medicine, 2013, 2, pp.128-132
Tbilisi State Medical University, Georgia; St. Andrew the First Called Georgian University of the Patriarchate of Georgia
Biological characteristics of Staphylococcus aureus strains multiresistant strains were studied. Their Results were compare to biological characteristics of non-multiresistant and MRSA strains. This three groups strains have similar morphological, tinctorial and cultural properties. Depend of their pathogenic factors, lower activity have non-multiresistant strains, higher activity – MRSA strains.
41. N. MANJAVIDZE, I. MANJAVIDZE, G. CHITAIA, M. TZIKLAURI, M. ABESADZE
THE FACTS OF BIOLOGICAL END FUNCTIONAL DEVELOPMENT OF REFUGEE CHILDRENEND FROM ABKHAZIA
J. Experimental and Clinical Medicine, 2013, 2, pp.132-134
TSMU Clinical Skills Center, Departament of Pediartics, Tbilisi, Georgia
There was performed investigation of the health status of 6-15 years old 800 refugee children from Abkhazia. The index of retarded biological development in the basic group is 10.3%. In addition the vital capacity of lungs in the basic group is decreased for 10.0%.