J.EXPERIMENTAL  &  CLINICAL  MEDICINE

 

2013, ¹ 5

 

1. Lejava J.

The lost art of the patient’s survey

Shota Rustaveli State University, Batumi, Georgia

J. Experimental and Clinical Medicine, 2013, 5, pp.9-12

 

Medicine practically forgets classical method of patient’s survey and doctors allocate less and less time to complete survey of the patients. 75 % of the information necessary for the diagnosis is gained during the survey. Also, hearty conversation of the experienced doctor with the patient has a therapeutic effect, which was so familiar to our famous ancestors. It is important to allocate more time and effort to these issues when preparing students and residents.

 

2. Vashasdze Sh, kekenadze M.

Stroke and leukocytes

Shota  Rustaveli State University, Batumi, Georgia

J. Experimental and Clinical Medicine, 2013, 5, pp.12-14

 

Our aim is to study interaction of cerebrovascular diseases and peripheral blood, to find new methods for prevention of this diseases. 100 patients was taking part in this study. They all where diagnosed with brain stroke at acute stage. One hour after stroke amount of neutrophils sharply rises (2-3 times more than norm) and it is directly linked to size of stroke. Because of that when lacunar ischemic stroke have had happened the amount of neutrophils is not raised, however when circulation syndrome is seen the amount of neutrophils sharply rises and it depends on size of stroke.

 

3. Gaprindashvili A., Masiukovichi T., Abuladze I., Emine Akyüz Turumtay, Kakulia N., Bakuridze L., Bakuridze A.

The study of the mineral resourses of Beshumi resort for their use in medical practice

Tbilisi State Medical University, Georgia

J. Experimental and Clinical Medicine, 2013, 5, pp.14-16

 

The rapid growth of the nomenclature of medicines in the 21st century is connected with a great consumption of the base of raw materials. Therefore, the search new raw material gains a serious actuality. The medicinal products are basically received from plant, animal and mineral raw materials and by the method of synthesis. Out of all mineral raw materials the particular interest by their use in medical practice gains clays, pelloids and mineral waters. Adjara is one of the regions of Georgia, rich with clays, pelloids, fresh and mineral waters, which are found on the seacoasts, as well as in the mountains. All these resources are known for the local population since the ancient times and were used to treat various diseases.

The aim of our research was to study Beshumi resort mineral resources for their use in medical practice. On the basis of the experimental studies there were investigated the micro-, and macro elementary contents of three important sources of Beshumi mineral resources: clays, pelloids and mineral waters.

In the studied samples there were detected the following micro and macro elements: Magnesium, Silicium, Sulphur, Potassium, Calcium, Ferrum etc. Based on its chemical composition, Beshumi clay can be used as a medicinal product, it is also recommended to use it as the base-wearing agent in the soft dermatological pharmaceutical products.

 

 

4. MAKSIMOV S., GATENADZE C., CHOMAKHASHVILI Z., ZOSIDZE N.

THE USE OF HYPERTHERMIA INTRAPERRITONEAL CHEMISTRY-PERFUSION AT THE COMBINED TREATMENT OF RELAPSE OF OVARION CANCER

Shota Rustaveli State University, Batumi, Georgia

J. Experimental and Clinical Medicine, 2013, 5, pp.16-21

 

In the article is considered the issue about combined treatment of relapse of ovarion cancer using the hyperthermic intraperitoneal chemistry-perfusion. Authors think that the data reported indicate on the aspect of the method and show us that its use at an early stage of treatment can lead to special success, especially in that case, when we find and will use new cytostatics, which allow the penetration of the tumors greater than 5 cm. Also is perspective prevention of intraperitoneal fibrosis and healing processes, which in this case hinder the uniform distribution of cytotoxic drugs in the abdominal cavity and sometimes causes the infectious [peritonitis, anterior abdominal wall abscess and abscess from catheter] complications and perforation of intestines. Based of the foregoing, we also think that the use of a cytotoxic drugs during the operation and its combination with hyperthermia is prospective.

 

 

5. AMIRANIDZE M., SIKHARULIDZE I., KORDZAIA M., SUMBADZE TS.

A POSITIVE EFFECT OF PARTIAL SPLEEN RESECTION IN TOTALLY IRRADIATED RATS ON THE MORPHOLOGICAL PICTURE OF THE LIVER

J. Experimental and Clinical Medicine, 2013, 5, pp.21-25

 

 

The purpose of the work is to determine morphological changes in the liver of totally irradiated rats in the conditions of partial splenic resection. The rats were divided into two groups; the animals of both groups were given a dose of 300R total-body X-ray irradiation from the RUM-17 roentgen apparatus. After irradiation, the rats of the II group were subjected to partial splenectomy under ether anesthesia. The experiment was over for the animals after 1, 7 and 15 days.

Microcirculatory disorders were marked in the 1st group rats; also were present pronounced dystrophic and necrotic changes, destruction of the intercellular membranes. In the rats of the II group (in comparison with the I group rats) were less prominent the dystrophic processes developing in the liver against the background of microcirculatory disorders. There was marked the reversibility of the pathological process.

 

6. M.Gurgenidze, M.Kiladze, Z.Beriashvili

Miniinvasive Surgical Interventions in Management of Acute CalculousCholecystitis

Department of Surgery of High Technology Medical Center–University Clinic;

Department of Surgery of O.Gudushauri National Medical Center;

Department of Surgery of Research Institute of Clinical Medicine, Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2013, 5, pp.25-31

 

The aim of the present study is to analyze outcomes after laparoscopic cholecystectomy (LC) and minilaparotomy cholecystectomy (MC) for different groups of patients according to the age, severity of disease and comorbid conditions.This is a multicenter retrospective review of 526 patients who underwent LC or MC between January 1, 2002 and December 31, 2008. The patients were categorized into LC (212) and MC (314) groups.When preoperative examination data were not reliable, we performed abdominal wall lifting with the retractors tovisualise abdominal cavity with laparoscope during minilaparotomy.There were statistically significantdifferences inconversion rate, mean operating time, mean duration of usage of non-narcotic analgesics postoperatively, intraoperative complications and inmean hospital stay.The difference in outcomes was more significant in elderly and senile patients.The minilaparotomy cholecystectomy is effective, safe and optimal operative procedure.

 

7. RAMISHVILI N., GOGIASHVILI L., CHIKHLADZE R., TSAGARELI Z., DGEBUADZE M.

ASSESSMENT OF THE TRANSFORMING GROWTH FACTOR TGF-β1 AND NEOCORTEX CHANGES AT EXPERIMENTAL ALCOHOL EMBRYOPATHY

TSMU, Departament of pathology and cytopathology; I. Javakhishvili Tbilisi State University,

A.Natishvili Institute of Morphology, Tbilisi, Georgia.

J. Experimental and Clinical Medicine, 2013, 5, pp.31-36

 

It was studied the ultra- and histostructure of the brain cortex anterior central gyri neural elements of  females alcoholize – rats offspring  received  the solution of 35% alcohol instead of water as follows: I series - 2 months prior to pregnancy + during pregnancy; II series - 2 months prior to pregnancy + 14-21 days of pregnancy (after a placentation period). Determined the amount of TGF-β1 in pregnant rats and their issue blood by ELISA («Elisa» kit, (R @ D system, USA).

It was shown that in the control group of animals and their offspring TGF-β1 levels in the blood do not change. In alcoholized offspring synchronously with the progression of neurodegenerative changes in cerebral cortex  layers cytoarchitecture is sharp increase of TGF-β1 in blood, at the same time, the axons and astrocytes structure and in their topography occur changes, indicating  the blockade of TGF-β1cellular receptors, followed by the myelin ultrastructure disturbance, the brain substrate edema and the glia dislocation. Results of the study suggest the link  of  TGF-β1 with astrocytes and gliocapillar membranes anti-alcohol resistance.

                                                          

 

8. kachkachishvili I., GAGNIDZE TS., korsantia b.

Immunological aspects of the clinical efficacy of various forms of camelyn for chronic parodontitis

Ltd “Mitra” Dental clinic, Doctoral student of TSMU;

TSMU Medical Biotechnology Institute, Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2013, 5, pp.36-41

 

Clinical and immunotropic effects of three methods of camelyn-therapy of chronic generalized parodontitis (oral administration and irrigation, electrophoresis) were studied. A marked clinical efficacy of camelyn was showed, particularly with the electrophoretics introduction of the drug. Preparation led to the normalization of the immunological parameters which were in correlation with the clinical status of patients. Comparative analysis of treatment showed the highest efficiency of electrophoresis and then - at irrigation of the mouth.

           

 

9. BUCHUKURI I., BAGDAVADZE M., NIKOLAISHVILI M., INTSKIRVELI N.

Mineralization and chemical composition of Mukhrani potable water

Beritashvili Biomedical Center, Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2013, 5, pp.41-43

 

 

Georgia is one of the countries rich in hydrological resources which are distinguished by both their quantity and quality and are renewable in time (1,2,3). Hydrological resources comprise plain, mineral and thermal waters.

Based on abovementioned, we can conclude, that potable water we explored is suitable for drinking and does not contain polluting substances. It is slightly alkaline, has good turbulence and can be considered as potable water of high quality.

 

 

10. Nikolaishvili M., Gogua M., Franchuki Q., Tufinashvili T., Vashakidze I.

Saferavi breed grape seed oil influence on cure of periodontitis

David Aghmashenebeli University of Georgia; Ivane Beritashvili Biomedicine centre,

Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2013, 5, pp.43-48

 

Oil extracted from Saferavi breed grape seeds by cold pressure in case of periodontitis, causes normalization of oral cavity enzymes action, inhibition of oral cavity inflammatory processes and at last their suppression. Exactly unique properties of oil became cure initiating and periodontitis starting stage stopping agent.

 

11. N.ALAVIDZE, M.GOGOTISHVILI, TS.GAGNIDZE, B.KORSANTIA

STUDY OF antiherpethic PROPERTIES OF LAZOLEx
In various experimental models

Akaki Tsereteli Kutaisi State University, Tbilisi State Medical University, Institute of Medical Biotechnology, Georgia

J. Experimental and Clinical Medicine, 2013, 5, pp.48-52

 

Studies have shown that Lazolex selectively neutralize the immunosuppressive effects of the herpes virus in white mice (reduction of mortality and virusemia, the restoration of immunocompetence of animals). The drug reduces the embriotoxity of virus from 29.6% to 18.8%, the overall postnatal mortality rate from 8.9% to 3.2%. The drug proved reliable gen-protective activity in herpetic infection: the number of aberrant chromosomes decreased to 15.8% (33.0% in controls) and the protective effect was achieved by reducing all types of mutations. Lazolex, can be successfully used for the prevention and treatment of viral (herpes) infections.

 

12. K.UKLEBA, L.GVETADZE, M.KHAPAVA, K.MERKVILADZE

NON-MEDICAMENTAL MANAGMENT OF THE ARTERIAL HYPERTENZIS IN THE PRIMARY HEALTHCARE SYSTEM

Akaki Tsereteli State University, Medical Faculty, Kutaisi, Georgia

J. Experimental and Clinical Medicine, 2013, 5, pp.52-56

 

 

The objective of our research was to improve the quality of primary medical services provided to patients with arterial hypertension. The research was based on the audit of medical services delivered at Kutaisi Family Medical Clinic. Medical history/map of totally 80 patients were selected.

The results of the conducted audit revealed that the quality of primary medical services provided to patients with arterial hypertension require serious improvement:

-        It is necessary to increase the number of applications from the patients with arterial hypertension that requires better developed Calling System for Patients that will ensure their regular visits.

-        The research has also revealed that the rate of quitting smoking among patients is only 20%. There is a need to develop individual quitting strategy for each smoker patient.

-        It is also proved that the consumption of alcohol is not decreased until the safer level. Achieved result does not meet the standards and equals 45%. Standard is not also achieved in terms of institutionalizing physical exercises (43% only). Explanation to this can be inadequate attention from Primary Healthcare team to these issues as well as ignorance form the patients' side.

-        As for the research on cardio protective diet it is reported to reach 83% among patients, indicating that the medical personnel is taking sufficient efforts.

It is absolutely necessary to conduct lectures and educational campaigns for patients at medical facilities about modifications of each risk factor causing arterial hypertension (non-dynamic lifestyle, smoking tobacco, excess weight, etc). It is vital to share the results of this audit with medical personnel (doctors, nurses) and conduct repeated audit in order to confirm effectiveness of the above measures taken.

 

 

13. Ye.V. Tsema, O.Ye. Yurkiv, A.Ya. Grushevsky, Yu.A. Kyselov, M.V. Nagnybedyuk

THE RESULTS OF SURGICAL TREATMENT RECURRENT SACROCOCCYGEAL PILONIDAL CYST

Central Hospital of Security Service of  Ukraine, Kyiv

J. Experimental and Clinical Medicine, 2013, 5, pp.56-59

 

 

The results of radical surgical treatment of 57 patients with recurrent pilonidal disease are presented in the article. 31 (54.4%) patients of the control group were treated by traditional surgical method (wide excision). 26 (45.6%) patients of the main group were treated by Bascom's procedure (cleft-lift procedure). There were 23 (74.2%) complications in patients of the control group: wound abscess (16.1%), primary (16.1%) and secondary wound dehiscence (19.4%), wound hematoma (12.9%) and repeat recurrent of disease (9.7%). There were 3 (11.5%) complications in patients of the main group: wound abscess (3.8%), secondary wound dehiscence (3.8%) and wound hematoma (3.8%). There was no repeat recurrent of disease after Bascom's procedure. The using cleft-lift procedure permits essentially decrease (χ2=22,4; Š=0,001) frequency of postoperative complications in patients with recurrent pilonidal disease.

 

 

14. S. Kraveishvili,  N. Shonia, N. SAKVARELIDZE

Characteristics of Ceramic Restoration Occlusion Correction with Bausch Articulating Paper

TSMU Department of Orthopedic Stomatology and Maxillofacial Orthopedics, Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2013, 5, pp.60-62

 

 

Goal of our study was identification of occlusion contacts, their study, comparison and analysis by means of Bausch articulating paper and wax occlusiogramms. Study demonstrated advantages of Bausch articulating papers for contacts’ identification in case of their application in certain order.

 

 

15. N. Shonia, S. Kraveishvili, N. sakvarelidze

Prevalence and Intensity of the Dentition Defects and

Secondary Deformations in 15-26 Age Group

TSMU Department of Orthopedic Stomatology and Maxillofacial Orthopedics, Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2013, 5, pp.62-65

 

 

Etiology & pathogenesis of caries and inflammatory diseases of parodentium is a subject of scientific researches and discussions. The above diseases cause early loss of teeth, resulting in disorder of speech and chewing functions, change of face shape, esthetic and psychosocial inferiority, pathologies of digestive and other systems. Our goal was study of characteristics of prevalence and intensity of the dentition defects and secondary deformations in 15-26 age group. Conducted research showed that: 43.3% of the studied patients had partial secondary adentia, and 38.8% or 1/3 of them had dentition deformations. Obtained results emphasize necessity of timely orthopedic intervention.

             

 

16. Kh. Kudava, T. Kituashvili

Efficacy of Terbinaphine in the treatment of Tinea capitis

Scientific-Research National Center of Dermatology and Venereology, Tbilisi State University, Department of Dermatology and Venereology,Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2013, 5, pp.65-69

 

The aim of our study was to define the efficacy and length treatment with Terbinaphine in various forms of Tinea Capitis caused by different etiological factors. 38 patients with Kerion form caused by Trichophyton mentagrophytes were included in the first group, another group involved 34 patients with Grey patch with single lesions caused by Microsporum canis. Patients were given Terbinaphine in following doses: 62.5 mg per day in patients weighing 10-20 kg; 250 mg per day in patients weighing above 40 kg. Medium length of treatment in case of Trichophyton mentagrophytes was 27, 8 days and in case of Microsporum canis – 37.6 days. The study revealed that Terbinaphine is effective in treatment of Tinea Capitis, namely in the treatment of Kerion form caused by Trichophyton mentagrophytes and Grey patch with single lesions caused by Microsporum canis.

 

17. v. malatsidze, s. koupradze, N.Borchkhadze

CLINICAL EFFECT OF NATURAL ZEOLITE ON liver fatty distrophy

Tbilisi State Medical University, Georgia

J. Experimental and Clinical Medicine, 2013, 5, pp.70-71

 

In the control group (15 patients), the number of cured was 47%, while in the basic group of patients receiving zeolites additive (27) cured reached by 90%. Analysis of the results of clinical and experimental research has allowed us to recommend the inclusion of zeolites in the treatment regimen liver, not only of alcoholic etiology, but also in other pathologies.