J.EXPERIMENTAL & CLINICAL MEDICINE
2015, ¹ 3
1. O.ABRAHAMOVYCH1, U.ABRAHAMOVYCH1, L.V. TSYHANYK1, O. SYNENKYI2, O.ROMANIUK1
THE INFLUENCE OF SYSTEMIC LUPUS ERYTHEMATOSUS DURATION UPON BONE REMODELING IN PATIENTS WITH OSTEOPOROSIS
1 Danylo Halytskyi Lviv National Medical University;
2 Lviv Regional Clinical Hospital; Ukraina
J. Experimental and Clinical Medicine, 2015, 3, pp.9-15
This article describes the analysis of the indicators of bone remodeling of serum of SLE patients with different disease duration. According to our results, these figures are significantly higher in patients with SLE compared with a group of healthy individuals that may be caused by a chronic autoimmune inflammation, and prolonged receiving of glucocorticoids.
Based on the results it was concluded that in patients with systemic lupus erythematosus are present features of bone remodeling depending on the duration of disease, with increased activity of remodeling in the early years of the disease, both osteoblastic and osteoklastic functions, and decrease with the increase of disease duration of 6-10 years.
In patients with the duration of systemic lupus erythematosus of more than 10 years, bone resorption is increased with the stabilization of the osteoblastic function.
2. V.PACHKORIA, A.PACHKORIA
THE ROLE OF PROSPECTIVE BIOMARKERS IN PROSTATE CANCER DIAGNOSTICS
Department of Topographic and Clinical Anatomy Tbilisi State Medical University;
Medical center ,,IKAMEDI”, Georgia
J. Experimental and Clinical Medicine, 2015, 3, pp.15-19
The main goal of prostate cancer tissue biomarkers is to improve diagnostic and prognostic accuracy. Despite extensive research efforts, very few biomarkers of prostate cancer have been successfully implemented into clinical practice today. Important technical advances together with histological techniques of antibody or probes conjugated with different fluorophores will certainly improve standardization and make immunehistochemical biomarker research more reliable and precise in the future. Cellular biomarker studies are also expected to change in the future towards a complex individualized profiling of human tumors with integrative analysis using different technologies, genome-wide scanning and expression profiling.
3. G.TEVDORASHVILI, D.TEVDORASHVILI, M.ANDGHULADZE, M.TEVDORASHVILI
SELECTIVE PROGESTERONE RECEPTOR MODULATOR (ULIPRISTAL ACETATE) - A NEW OPTION IN THE PHARMACOLOGICAL PRE-OPERATIVE TREATMENT OF UTERINE FIBROIDS
Tbilisi State Medical University, Department of Obstetrics and Gynaecology
Medical Center “Laser”, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 3, pp.19-22
Uterine fibroids are the most common benign, solid tumours of the female genital tract, affecting between 20 and 25% of women of reproductive age. Gynaecologists have long called for an effective medical treatment which can alleviate the symptoms related to fibroids and reduce fibroid volume. ESMYA® (Ulipristal Acetate/PGL4001)- PregLem’s most advanced product -is a selective progesterone receptor modulator (SPRM), which have shown, in recent studies, efficacy in controlling menstrual bleeding and reducing uterine volume, in symptomatic patients with uterine fibroids, whilst demonstrating a favourable side-effect profile.
4. N. MAMAMTAVRISHVILI, R. ABASHIDZE, N. SHARASHIDZE
ON THE SUBJECT OF DIAGNOSIS AND TREATMENT OF MICROVASCULAR DISEASE
Iv.Javakhishvii Tbilisi State University, Institute of Clinical Cardiology, Georgia
J. Experimental and Clinical Medicine, 2015, 3, pp.22-27
A link between myocardial ischemia and stenotic atherosclerosis of coronary arteries has been already established in multiple studies. Nevertheless, in considerable number of the patients with the typical angina and positive stress tests, angiography often doesn’t reveal any atherosclerotic changes in coronary arteries. The term “ microvascular angina “ (MVA) was introduced to define the pathological processes induced by the structural and functional changes in small coronary vessels. MVA is a widespread condition with the high risk of unfavorable outcomes requiring extensive diagnostic testing.
Different aspects of etiology , pathogenesis , clinical course, diagnosis, treatment and outcomes of MVA are reviewed in the study.
The authors suggest that further multifactorial investigations are needed for early diagnosis, evaluation of risk factors and signs of progression of the illness, as well as optimization oftreatment and prevention of the complications from MVA.
5. V. PACHKORIA, A. PACHKORIA
BIOLOGICAL THERAPY OF PROSTATE CANCER
Department of Topographic and Clinical Anatomy Tbilisi State Medical University;
Medical center ,,IKAMEDI”, Georgia
J. Experimental and Clinical Medicine, 2015, 3, pp.27-29
Bio-therapic strategies of prostate cancer are based on antigenic structure of malignant cells and contribute correction of immunó-reaction and enhancement of immunogenity of malignant cells. There are used as specific as non-specific methods of immunotherapy such as: cytokintherapy, vaccinotherapy, genotherapy, treatment with dendritic cells and their combinations together with other traditional methods. Mainly, the subjects for clinical studies are patients with disseminated androgen-undefended prostate cancer. The obtained data allows us to make hopeful prognosis.
6. A.SHARASHENIDZE, L. KIKALISVILI, D.MAKARIDZE, T.SANIKIDZE
MORPHOLOGICAL CHANGES IN THE PLACENTA OF WHITE RATS AT DIFFERENT STAGES OF PREGNANCY
J. Experimental and Clinical Medicine, 2015, 3, pp.29-35
The aim of the study was to evaluate the morphological changes in the placenta during a normal pregnancy. Placenta of the white rats was studied. At the 18th and 25th day of pregnancy the animals were killed by decapitation under ether narcosis. The placenta was investigated histologically and by immunohistochemistry (monoclonal antibody AE1/AE3, CD133 and Ki-67).
At the end of the third trimester of physiological pregnancy in the placenta arterial sinuses in the trophoblastic layer and mother and the fetus capillaries were slightly dilated. In the 3rd trimester significantly reduced volume of nucleated red cells fraction. In the three layers of the placenta (especially in the labyrinth layer) the degree of expression of AE1 / AE3 decreases in the third trimester, in trophospongiotic layer glycogen trophoblast cells does not occur (in the third trimester that should be regarded the norm). Expression of CD133 in a layer of giant trophoblastic cells and endothelial layer is relatively weaker in the 3rd trimester compared to the second trimester, indicating a decrease in the number of the endothelial progenitor cells. Study of distribution of the marker Ki67 indicates on the low proliferative activity in placental tissue in the second and third trimesters. The exceptions are the blood vessels that are involved in formation of vessels of the umbilical cord - there is a relatively high level of proliferation.
7. TURKIASHVILI L., KORAKHASHVILI G., METONIDZE B., BEGIJANASHVILI P.
LOCAL HEPATIC THERAPIES FOR METASTASES TO THE LIVER FROM UNRESECTABLE COLORECTAL CANCER
Tbilisi Oncology Center, Georgia
J. Experimental and Clinical Medicine, 2015, 3, pp.35-38
Colorectal Cancer (CRC) is a frequent form of cancer causing, about 40-50% of all deaths from malignant tumors. 40-45% of the patients with the above mentioned diagnosis have the secondary (MTS) minor liver injury in the phase of the initial diagnosing the disease. Unresectable damage of liver is also frequent.
Therefore it is important to select the optimal treatment for such patients to improve overall survival and quality of life.
8. PACHKORIA V.
THE RESULTS OF CLINICAL AND LABORATORY STUDIES AT UNLOCALIZED
PROSTATE CANCER
Department of Topographic and Clinical Anatomy Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2015, 3, pp.38-40
The results of clinical and laboratory studies of 76 patients with unlocalized prostate cancer have been studied. In addition to the clinical data of the patient, the scores of IPSS questionnaire, quality of life, sexual function, prostate volume, localization of hypoechogenic sites, urofluorometric indexes, results of examination of urinary organs, PSA level, ESR and blood count data have been assessed at unlocalized prostate cancer.
9. KOBAKHIDZE M.
THE EOSINOPHIL AND ITS ROLE IN ALLERGOLOGICALDISEASES
Tbilisi state medical university G. Zhvania academic clinic of department, Georgia
J. Experimental and Clinical Medicine, 2015, 3, pp.40-42
The appearance of the new fundamental knowledge about the structural and functional potential of eosiophils orients the researches towards the possible involvement of these unique cells in the mechanisms of implementation of many pathological processes. With the attraction of domestic and foreign literature data, the modern ideas about the role of eosinophilic granulocytes in the pathogenesis of diseases of noninfectious nature are emphasized in the review. Eosinophils are multifunctional leukocytes possessing a wide array of cytotoxic and immunoregulatory factors the action of which, on the one hand, is aimed to fighting the pathogen and on the other hand can be implemented with regard to healthy body tissues causing their damage and dysfunction.
10. MURVANIDZE E.
EFFECTIVENESS OF SYMMETRIC PHYSICAL EXERCISES IN CASES OF DYSKINESIA
Neurodevelopmental Center for Children;
University of Physical Education and Sports of Georgia, Tbilisi
J. Experimental and Clinical Medicine, 2015, 3, pp.42-45
The objective of the research was to study each movement of children with dyskinesia, which would make it possible to determine which habitual movement patterns interfere with the normal development and enhance anomalous development. Due to the asymmetry of bodies we applied symmetric physical exercises that would be targeted at inhibition of involuntary movements and on holding body midline.
11. NATROSHVILI N., NATROSHVILI T., KOBAKHIDZE M., NATROSHVILI N.
THE PREVALENCE OF DENTAL CARIES AMONG 12 YEAR OLDS, REFUGEES AND ITS ASSOCIATION WITH VARIOUS CHRONIC DISEASES
David Agmashenebeli University of Georgia, Tbilisi
J. Experimental and Clinical Medicine, 2015, 3, pp.45-47
Caries is one of the most common chronic disease in the world. 100% of the population suffer from caries in different time periods.
In 1997 WHO announced Oral Health as a priority and has set a goal for 2000 to decrease the DMF rate down to 3 worldwide. In the second half of the 20th century in the developed and developing countries, the prevalence of caries decreased, but in 21st century is still a noticeable increase in the prevalence of dental caries. Lots of studies are made worldwide about the prevalence of caries, including in Georgia.
Our study aimed to determine DMF index of 12 years old children of the internally displaced population in Georgia and to analyze the connection between caries and other chronic diseases. 403 children participated in the study, 200 boys and 203 girls. The final analysis of the DMF index was 8,2 (±7,0), which is quite high. Detailed results of the study of relationship between tooth caries and other chronic diseases will be published in the next publications.
12. V. PACHKORIA
THE RESULTS OF MORPHOLOGICAL STUDY, INVASION DATA AND THEIR CORRELATION WITH PROGNOSTIC FACTORS AT UNLOCALIZED PROSTATE CANCER
Department of Topographic and Clinical Anatomy Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2015, 3, pp.47-49
The results of morphological studies obtained in 76 patients with unlocalized prostate cancer have been studied. The number of biopsy material, Gleason score/sum, correlation of Gleason score with biopsy and postoperative material, correlation of Gleason score with prognostic factors have been evaluated. The data of invasion in postoperative material and rate of concommitant pathologies at unlocalized prostate cancer were studied as well.
13. ZURABIANI N., TADUMADZE L., PKHALADZE M.
SUPRACONSTRUCTIONS FIXED ON IMPLANTS
TSMU ¹1 Dental Clinic, Tbilisi
J. Experimental and Clinical Medicine, 2015, 3, pp.49-53
Choosing the supraconstructions type for orthopedic treatment after implantation depends on the number of implants and disposition of the teeth arc. Also,it is recommended to pay atantion to the aesthetic side which causes lengthening clinical crowns of teeth atrophied jaws.Besides type of construction it is also omportant to choose the material correctly. The goal of modern dentistry is to creat and refine the materials,which have the ability of amortization that is important for extending the period of using the implants.
14. MERKVILADZE N.1, SURGULADZE M. 1,2, TUSHURASHVILI P.1, EKALADZE E.1
USAGE OF NUCLEO CMP FORTE IN THE TREATMENT OF PERIPHERAL NEUROPATHIES
Department of Biochemistry, Tbilisi State Medical University;
,,Health Center” LTD, Georgia
J. Experimental and Clinical Medicine, 2015, 3, pp.53-57
Characteristic pathological feature of the damage in peripheral neuropathies is demyelination. In most cases therapeutic intervention is required for remielination. Nucleotides have shown to be effective in the treatment of diverse neurological syndromes from the point of nerve repair view.
The aim of our study was evaluation the results of inclusion Nucleo CMP Forte as nucleotide-based drug, consisting of Cytidine 5'-Monophosphate Disodium and Uridine Triphosphate Trisodium in the treatment of different types of neuropathy. Different schemes were elaborated including different regimes of Nucleo CMP Forte for treatment Research group patients (25 chosen patients with various types of neuropathy (facial neuropathy, lumbago, carpal tunnel syndrome). The control group patients (n=15) with peripheral neuropathy were treated without inclusion of Nucleo CMP Forte into the treatment. Our study indicates positive results of Nucleo CMP Forte in complex therapy of different peripheral neuropathies. Pain relief in shorter time, faster and valuable recovering of peripheral sensitivity and faster and effective recovering of normal functioning are evaluated as positive results of the research group.
15. ABAISHVILI N., MARGVELASHVILI V., TABORIDZE I., EGNATIEVI I., OMANADZE N., VASHAKIDZE I.
DISTRIBUTION DENTAL INDICES PERIODONTAL DISEASE OF THE STUDENT POPULATION OF GEORGIA
David Aghmashenebeli University of Georgia, IvaneJavakhishvili Tbilisi State University
J. Experimental and Clinical Medicine, 2015, 3, pp.57-60
The research aims to study dental periodontal disease indexes of the student population and the correlation between oral hygiene and periodontal inflammation index.
Materials and Methods: We investigated - 253 studenti’s universities periodontal health.We studied the bleeding index (Muhlemann),hygiene index – (Grammy-vermolion), and index PI (Russel). Correlation and regression analysis were conducted.
Results: Correlation analysis showed that significant positive correlation between periodontal index of the average of the index of average health indicators show (r = 0.312, p = 0.009). The bleeding index does not depend on the hygienic index (r = 0.112, p = 0.360).
Conclusion: The student population of hygienic index is predictor of periodontal disease.
16. *GRIGOLIA D., *BERIASHVILI R., *MOSIDZE K., **GOGITAURI M., **KAPANADZE R.,
**KIKALISHVILI N., *KILASONIA B.
MORPHOLOGICAL CHANGES IN SKIN AND INTERNAL ORGANS AT ELECTRIC INJURY
*Department of Forensic Medicine, Tbilisi State Medical University;
**Levan Samkharauli National Forensics Bureau; Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 3, pp.60-63
The purpose of study was to reveal the morphological pattern of different tissues mostly vulnerable to electric currency and affected by technical domestic electricity and determine the possible diagnostic criteria of this damage. The matter is of particular importance as technical domestic electricity apply is widely used method of torture and other cruel, inhuman and degrading treatment or punishment.
The microscopic study of slides taken from tissues damaged by electricity and dyed by routine Hematoxilin-Eosin reveals general structural changes that does not represent characteristic morphological pattern sufficient for forensic diagnosis of electric injury. Due to results obtained from the study there is considered in regard to determine the possible diagnostic criteria for electrical injury of tissues the morphological study must continue on skin and myocardial material using routine Hematoxilin-Eosin as well as other classical and modern morphological methods of study.
17. BEGIJANASHVILI P., JANJALIA M., SIKHARULIDZE I., TURKIASHVILI L.
THE ROLE OF TUMOR MARKERS IN THE DIAGNOSIS AND SELECTION OF TREATMENT OF MALIGNANT TUMORS
Tbilisi Oncology Center, Georgia
J. Experimental and Clinical Medicine, 2015, 3, pp.63-66
Often planned instrumental investigations do not provide an opportunity to diagnose cancer. Tumor markers are the link of research schedule that helps clinicians to confirm the diagnosis of cancer pathology; and often makes it possible to determine the correct tactics of treatment and extent of surgical procedure.
18. KITEISHVILI D.
STUDYING THE HISTOCHEMICAL CHANGES OF THYMUS DURING THE IMPACT OF LEAD IONS ON A HUMAN BODY
Tbilisi Medical Teaching University “Hyppocrates”, Georgia
J. Experimental and Clinical Medicine, 2015, 3, pp.66-68
The morphological study of thymus allows identifying the peculiarities of the course of the many processes taking place during the immune response of a human body. As our studies suggest, that thymocytes, which are responsible for the function of the matured lymphocytes, are quite active to acid phosphatase in case of different risk-factors. Acid phosphatase, as a lysosomal marker, was also seen in great numbers in the macrophage cytoplasm. Consequently, the activity of this ferment may also increase in peripheral blood. As the neutrophils, after shifting from the blood circulation, shift to the connective tissue and are transformed into macrophams, the increased number of neutrophils in case of lead intoxication can be considered as one of the diagnostic symptoms.
Thus, by correlating the morphological and blood biochemical studies, it is possible to identify a more efficient medicamental treatment to gain better results.
19. KITEISHVILI D.
INFLUENCE OF PREPARATION “RODEN” ON GEPATOSTEATOZ IN EXPERIMENT
Tbilisi Medical Teaching University “Hippocrates”, Georgia
J. Experimental and Clinical Medicine, 2015, 3, pp.68-71
The clinical using of hypolipidemic preparations cause many pathological proscesa and help to slow down its development, besides it improving a little prognoze too.
According to our experiment at extra feeding’s early stage takes place functional and morphological changes in hepatosit and metabolic syndroms factorsin hyperglicemic and in hyperlipidemic morphological substrats and by fatal infiltration, when glycogen increases in cytoplazm.
These changes in cytoplazm comes in order by decreasing of fatal infiltration or by disappearing in some cases, especially it takes place in female rats, in this case also takes place glycogenic and sour phosphats active normalization, without any entire teestablishment.
We think, that the preparat ,,Roden” pozitively acts on the normalization of metabolizm and its processes and demands a deep invastigation and learhing.
20. KITEISHVILI D.
EXCHANGE OF CARBOHYDRATES IN MYOCARDIUM DURING THE PANCREATIC DIABETES CAUSED BY ALLOXAN AT DIFFERENT AGES INFLUENCE OF PREPARATION “RODEN” ON GEPATOSTEATOZ IN EXPERIMENT
Tbilisi Medical Teaching University “Hippocrates”, Georgia
J. Experimental and Clinical Medicine, 2015, 3, pp.71-75
A metabolic syndrome is the result of the metabolic disorder. The syndrome implies dismetabolism of both, fats and carbohydrates. The accent in modern foreign literary sources is made on dislipidemia, and the disorder of the carbohydrates exchange is limited to hyperglycemia.
Thus, within the scope of our study, principal accent is made on the histochemical study of glycogen in myocardium and peculiarities and amount of their exposition in myocardiocytes, particularly, during the alloxan diabetes. As the complication of this disease is first of all seen as cardiac muscle ischemia and cardiac infarction in the first place, hyperglycosemia damages endotheliocytes, reduces their regeneration power and Co synthesis responsible for the reduced expansion of blood vessels. Hypoxia is the major reason for the reduced number of glycogen in sarcoplasm of myocardiocytes. At a young age, the reason for ischemia under stressful conditions is the radical reduction of the amount of glycogen, as the cardiac muscle uses great amounts of carbohydrates during the stress. At this age, mostly fine-grain glycogen is the case, which is mobilized quite swiftly. Consequently, coarse-grain glycogen and conglomerates of grains are formed in sarcoplasm hampering the mobilization of these polysaccharides and supply of energy to the cardiac muscle.
21. SAMUSHIA O., TS. MANDJGALADZE, S. CHKHAIDZE
DANDY-WALKER SYNDROME (Case report)
Tbilisi State Medical University, Neurology Department, Georgia
J. Experimental and Clinical Medicine, 2015, 3, pp.75-79
Congenital cystic malformations of posterior cranial fossa are manifested as Dandy Walker Syndrome, Dandy Walker variant, mega-cisterna magna, and as an arachnoid cyst of posterior cranial fossa. Differential diagnosis with the Jubert Syndrome, Meckel Gruber Syndrome, Arnold Chiari Syndrome and The COACH syndrome is of immediate interest. Two clinical cases of Dandy Walker variant in 14 year old identical twins Ni and Na are presented. The first symptoms appeared in Ni at the age of 12, and in Na at the age of 13. Ni’s symptoms were subacute: dizziness,loss of balance,active movement tremor was so pronounced that she couldn’t even attend classes. About a year later the similar, gradually increasing symptoms developed Na. Cranial MRI showed enlargement of posterior cisterna magna, hypoplasy of vermis verticis and cerebellar hemispheres, enlargement of the forth ventricle.