J. EXPERIMENTAL & CLINICAL MEDICINE
2016, ¹ 3
1. B. ZURASHVILI, N.VEPKHVADZE, M.GIORGOBIANI, N.KILADZE,
ASSESSMENT OF POPULATION HEALTH RISKS IN AKHALTSIKHE DISTRICT BY STUDYING SOME INDICATIONS OF FOOD SAFETY
TSMU, Department of Health Promotion, Department of Hygiene and Medical Ecology, Association of Medical Ecology, Consumer Assistance Service Center in Akhaltsikhe. Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.13-15
The aim of this work is to study the population health of Akhaltsikhe district and compliance of consumer market with hygienic standards in terms of protection of consumer rights.
The survey was conducted within the Eurasia Foundation-funded grant project –”Establishment of customer support centers” in Akhaltsikhe District.
The services offered to the population by the Consumer Assistance Center were evaluated positively by the population, entrepreneurs and related institutions. On the basis of obtained results the relevant guidelines have been developed.
2. N. ANTELAVA, N.GORGASLIDZE, A.KARSANIDZE, M.OKUJAVA,
INFLUENCE OF STATINS ON THE LIVER AND SKELETAL MUSCLE FUNCTIONAL ACTIVITY
Department of Pharmacotherapy, Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.15-18
The review deals with the most important side effects caused by statins. It is known that the use of statins significantly reduce mortality from cardiovascular diseases, and therefore there is a significant increase in their use and detection of side effects such as hepatotoxicity and myopathy. The literature indicates that the most severe complications of statins is different types of myopathy. The possible mechanisms of these complications are analyzed, it is indicated that the most significant is oxidative stress and mitochondrial dysfunction. Overview represents the interest for pharmacologists, doctors and researchers involved in developing new drugs.
3. D.TOPHURIA, L.BENASHVILI, M.MATOSHVILI, I. KAKHNIASHVILI
ACUTE LIVER INSUFFICIENCY
Tbilisi State Medical University, Department of Normal Human Anatomy; Department of Topographic Anatomy and Operative Surgery; Department of Dermatology and Venereology; Department of Clinical Skills, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.18-21
Acute liver failure (ALF) is defined by the appearance of signs or symptoms of hepatic failure and encephalopathy during the course of acute drug induced liver injury in a patient without previous or underlying chronic liver disease in less than 2 to 3 month time. The recovery from the loss of functional liver mass in acute liver injury occurs more readily than in the chronic setting because of the lack of long-standing fibrosis and portal hypertension, and the host’s overall better nutritional status. Therefore, if the individual can be supported properly throughout the acute event, and the inciting injury is removed or ameliorated, recovery will follow the rapid regeneration of liver cells.
4. D. CHIKVILADZE, D. METREVELI, KH. GACHECHILADZE, M. MIKELADZE
STUDY COMPARATIVE ACTIVITY OF CEFEPIME AND OTHER ANTIBIOTICS AGAINST NONFERMENTING BACTERIA AND SOME REPRESENTATIVE OF THE FAMILY ENTEROBACTERIACEAE
Tbilisi State Medical University, Direction of Pathology and Forensic Medicine, Department of Microbiology, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.21-24
The article presents data about comparative activity of cefepime and other antibiotics against gram-negative microbes from the family Enterobacteriaceae. Averages of 5% of all microbial strains were resistant to cefepime. The highest activity against members of the Enterobacteriaceae of cephalosporins had cephalosporin IV generation – cefepime. Antipseudonal and inhibitor protected penicillins had relatively low activity. The highest activity was characterized cefepime, ceftazidime and amikacin less. Considering that cefepime had high activity to bacteria from Enterobacteriace family which we studied, it can be used as one of the drugs of choice for the treatment of infections caused by gram-negative Enterobacteria.
5. D.TOPHURIA, I.KAKHNIASHVILI, L.BENASHVILI, M.MATOSHVILI
MANGANESE INDUCED NEUROTOXICITY – MANGANISM
Tbilisi State Medical University, Department of Normal Human Anatomy; Department of Topographic Anatomy and Operative Surgery; Department of Dermatology and Venereology;
Department of Clinical Skills, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.24-27
Manganese (Mn) toxicity is known to occur in certain occupational settings through inhalation of Mn-containing dust. The brain is particularly susceptible to this excess Mn and accumulation there can cause a neurodegenerative disorder known as manganism. Characteristics of this disease are described as Parkinson-like symptoms. The similarities between the two disorders can be partially explained by the fact that the basal ganglia accumulate most of the excess Mn compared with other brain regions in manganism, and dysfunction in the basal ganglia is also the etiology of Parkinson’s disease. The mechanisms by which increased Mn levels can cause neuronal dysfunction are yet to be elucidated. However, emerging studies are beginning to provide significant evidence of Mn effects on cortical structures and cognitive function at lower levels than previously recognized.
6. I.MCHEDLISHVILI, D.GELOVANI, T.MCHEDLISHVILI
STUDY OF MEASLES OUTBREAK IN TBILISI
TSMU, Department of Epidemiology and Biostatistics of Public Health Direction, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.27-29
During 2009-2012 in the whole Georgia as well as in Tbilisi only single cases od measles were detected. In 2013 the epidemiological situation drastically changed and measles epidemic broke out. That year 3743 cases were revealed in Tbilisi, in 2014 – 1365. The highest incidence level was indicated in children under 1 year of age. Adults, especially of the age group 20-29, were actively involved in the epidemic process.
Study of disease history of the cases showed that the vast majority of them either had not been vaccinated or had received only one dose of measles vaccine. In order to prevent measles epidemic in future, we consider it necessary to have coverage level with vaccination over 95%.
7. B. KURASHVILI, N. GORDJOMELADZE, G. KVERENCHXHILADZE, I. ZEDGENIDZE
STUDY AND EVALUATION OF CURRENT NOURISHMENT AND SUPPLY OF VITAMIN “C” AMONG PRESCHOOL AGE CHILDREN IN KVEMO KARTLI REGION
TSMU, Nutritional and Age medicine Department, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.29-32
Study and evaluation of current nourishment and supply of vitamin “C” among preschool age children in Kvemo Kartli region. Survey was carried out in winter (January-February) period, on 20 healthy children 4-6 years old, attending kindergarten in a village Khikhani in Marneuli region, for study and evaluation of current nourishment and supply of vitamin “C”.
Study results of current nutrition of children was following. All three components – proteins, lipids, carbjhydrats, were lower than normal. Therefore, callories of food ration was lower, than normal (1500, while 1970 kkal).
Deficiencies in vitamin “C” supply, where revealed by excretion of ascorbic acid vie urine, on an empty stomach, as well as, resistance state of peripheral capillaries to negative pressure.
8. K.MURJIKNELI, T.DARSANIA
THE RADIATION SAFETY OF THE PATIENT WITH X-RAY STUDIES
TSMU, Environmental Health andOccupational Medicine Department, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.32-34
It is known that at present total dose of population radiation from all sources makes up 4.2mZv/per year. According to the recommendations of the Radiation Protection International Commission the quantity reducing stochastic effects to the minimum level is 5mZv/per year, this means that the current actual radiation dose of population is limited. The aim of the study was to study the statistic data of X-ray procedures conducted in Georgia during recent years and calculate the average maximum effective doses for radiological procedures. As shown by the statistical data, the volume of radiological procedures is increasing, which is the basis to excess the population doses. We have proposed the calculation of effective doses in four main age groups, it can be used to assess the patient’s radiation after X-ray examination.
9. T. LOMSIANIDZE
PRESCHOOL CHILDREN’S PHYSICAL DEVELOPMENT INDICES COMPLEX REVIEW
Akaki Tsereteli State University. Kutaisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.34-36
The study includes a comprehensive analysis of pre-school children physical development indices. The two pre-school facility of Kutaisi is being observed in 3 to 5 years children. The number of examined children is 125 in total. Data analyzes indicate that this age group and physical development is rapidly going on. Reveals some relationship both in medical and physical histories with children as well as their parents.
10. I.ANDRONIKASHVILI, G. SIMONIA, D. GORDELADZE, P. NOZADZE, N. PANTSULAIA
SODIUM PUMP ENDOGENOUS INHIBITORS, SALT- SENSITIVITY AND
SALT-SENSITIVE HYPERTENSION: STUDY IN GEORGIAN POPULATION
Institute of Medical Biotechnology, Department of Geriatrics, Department of Internal Medicine, Tbilisi State Medical University, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.36-40
Clinical and experimental studies suggest possible multi-level involvement association ofsodium pump endogenous inhibitors (EO and MBG) in the development of salt-sensitivity in normotensive subjects and in pathogenesis of salt-sensitive hypertension.
The goal of our study was to elucidate the role of EO and MBG in the development of salt-sensitivity and salt-sensitive hypertension in Georgian patients.
Results of our preliminary study showed that in Georgia both healthy and hypertensive subjects consume high amount of sodium. Development of salt-sensitivity and salt-sensitive hypertension might be due to sodium pump endogenous inhibitors. Based on our results we would suggest that high incidence of hypertension in Georgia might be related to the prevalence of salt-sensitivity in both normotensives and hypertensives.
Our results have shown that in Georgians prevalence of salt-sensitivity exceeds average values and development of salt-sensitivity, and salt-sensitive hypertension might be due to increased production of sodium pump endogenous inhibitors.
11. LOMTADZE L., KAJRISHVILI M., ZARNADZE I., BARAMIDZE L., KITOVANI D.,
CHIRAKADZE S., MURJIKNELI K.
GERERAL TENDENCY OF MATERNAL DEATH RATE IN GEORGIA
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.40-42
All over the world maternal and newborn health is priority. Every year the Maternal Mortality Estimation Interagency Group publishes the maternal mortality estimates. Generally, these, differ from official statistics. Over the years, the estimates for Georgia are higher than official data and survey results. In Georgia it stays as challenge. The results of our study show, thaf maternal mortality rate is still high.
12. LEKISHVILI G., ARZIANI B.
EFFECT OF SUBSTITUENTS ON SCAVENGING ACTIVITIES OF PHENOLIC
Department of Medical Chemistry, Tbilisi State Medical University, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.43-44
QSAR models of scavenging activities of phenolic Schiff bases has been constructed where r2=0.99 and relative importance of substituents was suggested.
13. KHUNASHVILI N., KVERENCHKHILADZE R., TSIMAKURIDZE MAR., BAKRADZE L., KHACHAPURIDZE N., ZURASHVILI D., MAIA TSIMAKURIDZE, G.KVERENCHKHILADZE
OCCUPATIONAL FACTORS AND HEALTH OF TBILISI SUBWAY WORKERS
Department of Environmental Heals and Occupational Medicine of Tbilisi State Medical UniversiTy, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.45-47
The analysis of results of hygienic-clinical researches of working conditions and state of health of workers of the Tbilisi subway is carried out. The production environment and labor process of workers of the subway is characterized by existence of a complex of adverse factors among which the leader is production dust, and also toxic gases, a microclimate, noise and vibration. Studying of a state of health revealed existence of diseases of cardiovascular and nervous systems, and also bodies of a digestive tract. Dynamics of development of these diseases allows to carry them to the diseases caused by a profession. On the basis of this research the complex of improving actions is developed.
14. BEZARASHVILI S., ARABIDZE M., KVERENCHKHILADZE R.
ANALYSIS OF A CONDITION OF ATMOSPHERIC AIR OF TBILISI
Department of Environmental Heals and Occupational Medicine of Tbilisi State Medical University, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.47-49
The results of monitoring of a state of pollution of Tbilisi free air on the basis of data of Ministry of Environment and Natural Resources Protection of Georgia are analysed. The question is studied in dynamics, during 2011-2015. It is established that the condition of àtmospheric air of the city of Tbilisi is extremely adverse concerning existence of high concentration of suspended particles (dust) and a number of chemicals (a carbon monoxide, nitrogen dioxide, ozone). In recent years the tendency of their increase is revealed. The main role in it is played by a tendency of increase in the production capacities and the motor transport. Modernization of monitoring system of a condition of àtmospheric air is necessary.
15. KAJRISHVILI M., LOMTADZE L., ZARNADZE I., BARAMIDZE L., KITOVANI D.,
KEKELASHVILI X., MURJIKNELI K.
LEARNING PATIENTS SATISFACTION ON ABOUT MULTI PROFILE CLINIC
TSMU Department of Public Health, Management, Policy and Economic,
J. Experimental and Clinical Medicine, 2016, 1, pp.50-52
Aim of our research was study patient’s satisfaction. 120 patients were interviewed. Study reveal that 100% of patients were satisfied of doctors professionalism. 96% notes that information given was understandable. 95% of respondents were contented about nurse’s attitude. 96% of users were satisfied of sanitary conditions. The survey shows, that addressing medical institutions has grew. Patients are not afraid of getting to clinic, because they are insured.
16. TOPHURIA D., BENASHVILI L., KAKHNIASHVILI I., MATOSHVILI M.
METABOLIC CHANGES OF ALCOHOL AFFECTED LIVER
Tbilisi State Medical University, Department of Normal Human Anatomy; Department of Topographic Anatomy and Operative Surgery; Department of Dermatology and Venereology;
Department of Clinical Skills, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.53-55
Complications from alcohol-related liver disease (ALD) usually occur after years of heavy drinking. These complications can be serious. Although there is a clear relationship between the risk of ALD and the dose of alcohol consumed, additional risk factors include genetic predisposition, gender, nutritional status, obesity, and co-existing liver diseases such as hepatitis C. ALD ranges from steatosis to alcoholic steatohepatitis and established cirrhosis. Several mechanisms are involved in the pathophysiology of ALD, including oxidative damage secondary to alcohol metabolism, and endotoxaemia leading to tumor necrosis factor a-mediated cell damage and death. In case of unsuccessful therapy of abstinence period should be considered liver transplantation.
17. CHINCHARADZE S., VADACHKORIA Z., MCHEDLISHVILI I.
PREVALENCE OF CLEFT LIP AND PALATE IN GEORGIA
TSMU, Department of Surgery of Direction of Child and Adult Stomatology (Dentistry) and Prevention of Stomatological (Dental) Diseases, Department of Epidemiology and Biostatistics of Direction public health, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.56-58
Cleft lip and palate are one of the most common congenital malformations. On average, about one in every 700 live births results in a cleft lip and palate in the world. In Georgia prevalence rate is 0,65±0,15per 1000 births during 2011-2014. However, its frequency varies across regions. For example, in Mtskheta-Mtianeti region prevalence rate is 2,02 per 1000 and in Samtskhe-Javakheti region – only 0,14 per 1000. This pathology is not widely spread in Tbilisi, where the prevalence rate is 0,27±0,06 per 1000 births at the time of the research.
18. NEMSITSVERIDZE N., TCHUMBURIDZE T., DUGHASHVILI N., CHIKVILADZE T.,
ZARKUA T., VORONOVI S.
ETHICAL ISSUES IN CLINICAL TRIALS OF DRUGS
TSMU department of social and clinical pharmacy, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.59-60
Clinical research of new medications is necessary for improvement of pharmacotherapeutical methods and monitoring of drug efficacy. Clinical researchis conducted on humans and is used for evaluation of safety and efficacy of drugs. The aim of this work was to determine, if the current situation in Georgian clinics gives the opportunity to conduct more large scaled and numerous trials, and if clinical studies conducted in Georgia are relevant to the international standards or not. The method of the study was the survey of relevant service employees of Ministry of Labor, Health and Social Affairs of Georgia. The study results revealed that clinical trials in Georgia are conducted according to the internationally recognized standards and guidelines. Lepel State Regulation Agency for Medical Activities performs the audit of current studies in Georgia. Relevant ethical committees control the standards of conducting clinical studies. In conclusion, it can be noted, that existing situation in Georgia gives the opportunity to conduct clinical research and further develop this branch.
19. GAGOSHIDZE M., GOGBERASHVILI K., PAGAVA K., TABORIDZE I., ALADASHVILI L., PETRIASHVILI A.
TRACE ELEMENTS IN CHILDREN LIVING AREAS CONTAMINATED WITH ARSENIC
TSMU Department of Pediatrics. Geomed. Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.61-64
The aim of our work is to determine of trace elements and establish links between them in children living in contaminated areas with arsenic (Lukhuni Gorge in the region of Racha). We observed 12 children aged 7-15 years. An indicator of arsenic exposure used hair.
Compared to the standards of the average concentration of arsenic significantly increased and Zn in the hair, and significantly reduced the concentration of potassium bromide, selenium, manganese, and copper. A positive correlation was established between the concentrations of As with Br, and negative - As with Se. Ca reveals a negative correlation with Zn and Mn. Mn shows a positive correlation with Zn, Fe and Cu with S, Cu and Sr with S, Se negative with Br.
20. ZURABASHVILI D., PARULAVA G.
NON–SMOKERS AND THE LEVEL OF NICOTINE IN TOBACCO SMOKE
Center for Mental Health and Prevention of Addiction;
Georgian State Teaching University of Physical Education and Sport, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.64-67
The aim of the work is study migration dynamic of nicotine in Tobacco Smoke. Gas-Liquid Chromatography with high-resolution capillary column is applied. Cigarettes were machine-smoked and the total particulate matter was collected. The mainstream smoke was monitored continuously in real time (3.0; 5.0 and 10.0 min.) on puff-by-puff. Our data show, that the distance and the length of exposition have different effect on the level of nicotine in the structure of Tobacco smoke. The studies are necessary to be held in different direction. First, the medico-ecological consequences of Tobacco smoke and the ways of their curing should be identified. The second direction should mean elaboration of preventive measures of intervention.
21. JIKIA G., MUSELIANI T., NIKOLAISHVILI M.
THE EXISTENCE OF HARD METALS IN THE RIVER ALAZANI
I.Beritashvili Center of experimental biomedicine, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.67-69
The analyses of the results show that the concentration of the dissolved metals in the waters of the river Alazani – iron, zinc, copper, nickel, lead and manganese is lower than the corresponding rates, which is provided by pH of the water. It influences the hydrolysis of these metals and the bulk settles on the bottom and the rest sorbs on the floating particles of the water.
22. KOCHLAMAZASHVILI A., NASKIDASHVILI M.
UNION OF GEORGIA-FOREIGN COUNTRIES FRIENDSHIP INTERNATIONAL SOCIETY
Preventive Cardiologic Room, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.70-71
Union, Community of Georgia – Foreign countries, in preventive cardiology office existed at the international society (Tbilisi, 78 Uznadze str.) in 2013-16 years (during three years), conducted observation on 200 (30 women and 170 men) almost healthy patients aged from 50 to 75 years inclusive (both middle-aged and elderly) who, on the basis of joint subjective-objective, clinical-laboratory and instrumental studies, had not organic changes due to ischemic heart disease.
23. JAPARIDZE N., KHAZARADZE K., KHAZARADZE R.
CHALLENGES FOR ECOLOGICAL SCIENCE ADDRESS ECOLOGICAL CRISIS IN GEORGIA
The Ministry of Labour, Health and Social Affairs of Georgia; Georgian State University of Physical Education and Sport; Georgian Agrarian University; Tbilisi
J. Experimental and Clinical Medicine, 2016, 1, pp.72-73
The paper analyzes the environmental and financial problems. We have summarized the results of environmental studies. It is important to mention that the solutions to overcome the ecological crisis are defined. We conducted compliance analysis and outlined urgent goals. Georgia is an important country in the European region in terms of endemic nature. It will be possible to maintaining sustainable development of national economy by regulating human beings material needs in the growing conditions. The complex measures must be developed and implemented in these directions.
24. GARUCHAVA M., PARULAVA G.
BIOTRASFORMATION OF HERBICIDES OF PHENOXYACETIC ACID DERIVATIVES AND ECOLOGICAL STATE OF ENVIRONMENT
J. Experimental and Clinical Medicine, 2016, 1, pp.74-76
It is set the metabolic pathway of herbicides derivatives 2,4-D in annual cereal plants. As a result of herbicide oxidative conversion the products of hydroxylation of the aromatic ring are formed. Paths forming conjugates are set. It is set that hydroxylation of the aromatic ring in studied cultures mainly occurs in the P-position. It sets the ratio of metabolites resulting from hydroxylation of the aromatic ring. 2,4-dichlorophenol in Sudan grass was first discovered by us. It suggested that on the basis of the environmental situation of the country, the study of herbicides gives us the opportunity to improve hygiene standarts of resudal amounts of herbicides and their metabolites.
25. GEGENAVA KH., JAPARIDZE SH., KEVANISHVILI Z., LOMIDZE L.,
SVANIDZE N., TUSHISHVILI M.
TRANSIENT EVOKED OTOACOUSTIC EMISSION – METHOD FOR ESTIMATE HEARING FUNCTION IN SMOKERS
National Center of Audiology; National Centre of Otorhinolaryngology; Simon Khechinashvili University Clinic; TSMU, Department of Otorhinolaringology; Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.77-83
Transient evoked otoacoustic emission (TEOAE) test is used to determine cochlear status, specifically hair cell function. The purpose of the study was to evaluate the effect of smoking on hearing function by using TOAE. Material and methods: Research was conducted at National Centre of Otorhinolaryngology and National Center of Audiology. The data were collected from octomber 2013 to May 2015. 120 persons within the age range of 30-65 were involved into the research, among them 60 smokers (average age – 52.7±8.3) and 60 nonsmoker (average age 50.8±11.7) were involved in the present study. All OAEs measurements were performed by Madsen Capella’s-OAE/middle ear analyzer-GN Otometrics, Danmark in both groups. After all persons were measured by pure tone audiometry (MA-30 and MA-31, Präcitronik). The received results were statistically treated by student t-criteria (p<0.05).
The results show that the audiograms of all subjects with normal TOAEs were in normal ranges. The main difference between the data of TOAEs and audiograms was established in smokers’ group: decreased amplitude of TOAE revealed in 51 subjects and 46 of them had no changes on their audiograms: it means, that 90,2% (P<0,05) of the smokers without complains and with normal audiograms have subclinical, hidden hearing problems. TOAE, as significantly sensitive method can be used for evaluation of subclinical dysfunction of hearing, when there are no subjective complaints on hearing loss and hearing thresholds on audiogram are normal as well.
26. GUMBARIDZE L., BARAMIDZE L.
SOME ISSUES OF UNIVERSAL HEALTH INSURANCE PROGRAM IN GEORGIA
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.83-85
The goal of the article is to make an overview and observation of the universal health insurance program developed by the Government of Georgia since 2013. Analysis of the key strengths, weaknesses and challenges of the program based on the review of current processes and statistical data.
27. KVIZHINADZE N.., DUGASHVILI N.
THE PRINCIPLES OF THE NATURE OF ORGANIZATIONAL STRUCTURE
Tbilisi State Medical University, Social and Clinical Pharmacy, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.86-87
The extent of structure in organizations, varying from a high to low amplitude. High amplitude refers to a radical change of the newly reformed company set-up concerning the organizational culture, structural composition, procedural activities or individuals from the previous state. On the contrary, low amplitude of change implies a reasonable transformation to the former environmental conditions through the intended plan. The change context is the why of change. The social, economic, political and competitive environment in which the organization operates is referred to as outer context; whereas the culture, structure and capabilities of the organization belong to the inner context.
28. Chitashvili D., Korinteli E., Berianidze N.
The data on the training of acrobats of different ages and gender during the preparation to the precompetition period
Ilia State Univesrity; The Georgian State Educational University of Physical Training and Sport, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.87-89
On the basis of the study of the correlation of physical properties and functional changes in sportsmen of high qualification a team of acrobats of Georgia has been staffed.
29. DONDOLADZE KH., BULISKERIA L., NIKOLAISHVILI M., ZURABASHVILI D.
STUDY ON THE EFFECT OF GHRELIN ON MEMORY AND CONCENTRATION OF PEOPLE WORKING IN THE ELECTROMAGNETIC FIELD
Center for mental health and prevention of drug addiction, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.89-91
The electromagnetic field acts on the memory and concentration, in particular by impact stress-induced food routine. The electromagnetic field induced by stress and stress the consumption of food, in turn, leads to a decrease in plasma concentrations of Ghrelin. This may be one reason to the problem of reducing the memory and concentration in people working in the electromagnetic environment.
30. MIRVELASHVILI E., KIKACHEISHVILI E.
DIABETIC COMPLICATIONS IN DIFFERENT GROUPS OF PATIENTS
Public Health Department of the Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.92-93
The number of people with diabetes increasing worldwide. Diabetes of all types can lead to complications in many parts of the body and increase the risk of dying prematurely. Possible complications include heart attack, stroke, kidney failure, leg amputation, vision loss and nerve damage.
The aim of our study was to investigate the spread of diabetic complications in different groups of patients. The questionnaire was drawn up for data collection. Total surveyed 1000 patients. Among the respondents, diabetic complications have been reported in 531 (53.1%). The largest number of patients was in the group, which included patients who do not control disease. And the frequency of diabetic complications is high in this group, where patients do not have adequate monitoring of the disease.
31. JAVAKHADZE R., TSERETELI M., CHIGOGIDZE KH., KHATIASHVILI N.,
RUKHADZE N., GVABERIDZE O., SVANIDZE T.
THE LABOR AND HEALTH AT COAL MINING INDUSTRY
N. Makhviladze S/R Institute of Labor Medicine and Ecology, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.94-96
Among of the Georgian industries one of the leading is coal mining and processing at Tkibuli mines, what is important for economic development of Georgia. The industry environment is characterized by unfavorable occupational factors and the real professional risk exists for employee’s health. At institute since 2007 the state program “The prevention of occupational diseases” held, in which frame at Tkibuli mines were done hygienic, toxicological, epidemiological and clinical studies. The results formed the basis of activities for improvement health of employees.
32. BERIDZE K.
THE IMPACT OF PHYSICAL ACTIVITY ON CHILDREN’S MENTAL FUNCTIONS DEVELOPMENT INDEX
Faculty of Physical Medicine and Rehabilitation, Georgian State teaching university of physical education and sport, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.97-99
The recent rapid increase of the volume of information and emotional load raises children’s mental requirements. Mental activities that are identified by physical processes such as: attention, memory, thinking, etc. becomes active, develops and forms in the process of the physical exercise.
This paper aimed to identify the impact of the physical education classes on a 10-12 year old students. The research was conducted in two public schools in Tbilisi. In the first school the physical education classes are held on a regular basis, whereas in the second school there are no physical education classes at all. In total 47 schoolchildren from 10 to 12 years old were examined. We studied reasoning – with the test “exclude the word”, (aimed for 10-12 year old schoolchildren); the dynamics of learning skills – “memorizing 12 words”; Perception reaction – with the “Schult” test.
As the result analysis show, in the first school where physical education classes are held on a regular basis, schoolchildren’s mental development index, particularly: reasoning, memorizing skill and perception reaction – is significantly higher.
33. VEPKHVADZE N., TSKHOVREBADZE N., KUGOTI I., TSKHOVREBADZE I.,
RADIOECOLOGICAL SITUATION IN MTSKHETA-MTIANETI REGION AND RATE OF GENETIC DISORDERS IN INFANTS
Department of Preventive Medicine and Environmental Health, TSMU, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.100-102
Dose-response relationship between radiation background and rate of genetic disorders in infants of Mtskheta-Mtianeti region have been studied.
Determined, that radiation background of investigated territories is not only reason of increased genetic disorders in infants. Relatively high radiation background combined with existing low level hazardous factors have negative influence on the health status of population, including infants.
Thus, it is nesessary to implement measures for reduction of irradiation doses of population.
34. VEPKHVADZE N., KILADZE N., KOCHORADZE T., TSKHOVREBADZE N., KHORBALADZE M.
IMPACT OF NITROGEN DIOXIDE ON THE HEALTH OF POPULATION
TSMU, Department of Hygiene and Medical Ecology, Department of Health Promotion
J. Experimental and Clinical Medicine, 2016, 1, pp.102-104
The possible relationship between levels of nitrogen dioxide in the air and incidence of respiratory diseases among the population has been studied.
Identified that there is no relation between the concentration of nitrogen dioxide in the air and incidence of respiratory diseases among the population.
It has to be considered, that besides nitrogen dioxide there are many adverse factors with small intensity, which are also risk factors for development of respiratory diseases. Isolated action of these factors with certain concentrations may not demonstrate any adverse effect on human health, but the combined effect of their action is stronger and obviously will affect general health and specifically - respiratory system.
Implementation of urgent measures for further improvement of the ambient air quality has been recommended, which will be the basis for minimizing the incidence of many chronic diseases.
35. MURUSIDZE L., ZARNADZE I., ZARNADZE SH.
HUMAN RESOURCES DEVELOPMENT POLICY PARTICULARITIES IN THE HEALTHCARE
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.105-107
National particularities in the field of the human resources of healthcare in Georgia have to be basis for determination of strategic direction of human resources development and education policy. Working out of the human resources development policy and long-term plan, funding of critical specialties and employment of sought-after experts in coastal and mountainous regions, coordination and standardization of continuing and medical education are necessary. The Government should promote prioritized scientific researches of both governmental and international grant programs in cooperation with the US and Europe Disease Control Centers, leading medical schools/universities , research foundations and other international partner organizations.
36. GVINERIA I., TSERETELI M., JURULI M., SAAKADZE V., ONIANI T., GVABERIDZE O.
ARSENIC - HEALTH RISKS, REGULATION OF THE WAY
N. Makhviladze Scientific-Research Institute of Labour Medicine and Ecology, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.108-110
Real picture regarding the environmental and food contamination by arsenic in Georgia is presented. Established a causal link between arsenic exposure and the pathological processes in the body of the employees working in ore extraction and processing. Under the statistical data high rate of cancer was shown In Racha-Lechkhumi population.
Expressed the opinion that in order to protect population health against exposure to arsenic and its compounds, it is necessary to establishe higienic norms in environment and especially, in food products according to international requirements and control mechanisms.
37. CHKHAIDZE N., GVINERIA I., TURMANAULI M., SHUBLADZE KH., BARATASHVILI R., GVISHIANI M.
ASSESSMENT OF THE HEALTH RISK OF SUBURBS POPULATION OF LTD ,,SAQCEMENT“ CEMENT FACTORY IN KASPI
M.I. Makhviladze Labor Medicine and Ecology S/R Institute, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2016, 1, pp.111-113
The research in order to assess the health risk of population of suburbs of Ltd ,,Saqcement“, cement factory in Kaspi (approximately 2 km radius) revealed the various symptoms of different organs and systems caused by cement dust, in particular, the cardiovascular system, malignant tumors, diseases of respiratory system (bronchitis, asthma, pneumoconiosis) and, as well as anomalies, and to some extent the reproductive system changes with the dynamics of growth trends that are likely to correlate with pollution of the study area (air, water, soil) and the risk to health. This view is confirmed by the fact that part of the studied contingency, except that it works or has worked in “KaspiCement“, in the last 10 years lives surroundig of the plant, powered mainly of products purchased on the market, which may be contaminated with various chemicals.