J.EXPERIMENTAL & CLINICAL MEDICINE
2017, ¹ 3
1. D. TOPHURIA, M. MATOSHVILI, L. BENASHVILI, I. KAKHNIASHVILI, I. AMIRANASHVILI
CADMIUM TOXICITY OF THE LIVER
Tbilisi State Medical University, Department of Human Normal Anatomy, Department of Dermato-Venerology, Department of Topographic Anatomy, Department of Clinical skills, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp.12-15
In conclusion, many studies have shown that Cadmium (Cd) induces hepatocellular damage by an imbalance in the cellular redox status which leads to oxidative stress, although there are many questions pending to address regarding the exact mechanism of Cd-induced damage, we know that Cd compete with metal sites in many protective or antioxidants proteins inducing an improper activity and even the total loss of the antioxidant cellular defense, in addition the disturb in Ca homeostasis lead to the activation of PKC which drives many of the noxious effects initiated by ROS. Moreover, Cd depletes GSH and other sulf-hydryl groups, which aggravates the oxidative stress and the cellular damage resulting in apoptosis. Finally all liver cells are involved in the Cd-induced damage; the inflammatory response elicited by Cd generates the infiltration and activation of phagocytic cells releasing more inflammatory mediators such as cytokines, or ROS. Further deeply research is needed to figure out the complete mechanism of hepatocellular damage induced by Cd in order to set up proper therapeutics approaches for chronic and acute Cd intoxication.
2. M.MATOSHVILI, D.TOPHURIA, N.ADAMIA, I.AMIRANASHVILI
ONYCHOMYCOSIS IN PATIENTS WITH PSORIASIS AND OTHER SKIN DISEASES
Tbilisi State Medical University, Department of Dermato-Venereology, Department of Human Normal Anatomy, Department of Pediatrics, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp.15-17
Onychomycosis is the most common disease of nails and constitutes about a half of all nail abnormalities. But onychomycosis among psoriasis patients is reported with varying prevalence. There were suggestions that dystrophic nails in psoriatic patients lose their natural preventing barrier and therefore are more predisposed to fungal infection.
We studied the occurrence of onychomycosis among patients with psoriasis versus patients with other skin diseases during 1year. Scrapings from clinically abnormal nails (both fingernails and toenails) were examined using microscopy and culture. The prevalence of onychomycosis in patients with psoriasis was 19/71~26.8% compared to 21/107~19.6% for patients with other skin diseases.
It is concluded that the frequency of onychomycosis among patients with psoriasis compared to patients with other skin diseases is not significantly different. In reasonable cases, the mycological examination is required, especially when the clinical picture of the nails suggests the presence of fungal infection.
3. D. ZURABASHVILI, G. PARULAVA
THE LEVEL OF NICOTINE IN TOBACCO SMOKE
Center of Mental Health and Prevention of Addiction; Georgian State Teaching University of Physical Education and Sport; I. Javakhishvili Tbilisi State University; Georgia.
J. Experimental and Clinical Medicine, 2017, 3, pp. 18-20
The level of nicotine in indoor Tobacco Smoke substances were analyzed and identified by capillary gas-chromatography method. The distance to light cigarette and the length of exposition were account. Our data show, that the concentration of nicotine on various distances from the lighting cigarette is depended on investigate time after smoking process. The obtained data is very important from the point of ecological assessment of the environment composition of tobacco smoke.
4. GARUCHAVA M. PARULAVA G. 20-22
FOOD PRODUCTS SAFETY AND FACTS OF ITS INFLUENCE
Georgian State University of Physical Education and Sports, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 20-22
The source of chemical and microbiological food production is studied. Zoonotic agents which are the source of the illnesses are caused by food production. Chemical sources of Pollution are studied and identified metabolites of organochlorine pesticides. their toxical characteristics are established. It is suggested that Decisive importance in avoiding existing risk factors of food products safety is in proper analyze of suggested hazards.
5. N.VEPKHVADZE, N.KILADZE, B. ZURASHVILI, T.KOCHORADZE, N.TSKHOVREBADZE CONCENTRATION OF TOTAL SUSPENDED PARTICLES IN TBILISI AND IT’S POSSIBLE HEALTH EFFECTS
Tbilisi State Medical University, Department of Preventive Medicine and Environmental Health
J. Experimental and Clinical Medicine, 2017, 3, pp. 22-24
Concentration of total suspended particles (TSP) has been studied in Tbilisi. The highest level 0,9 mg/m3 which was six times higher than maximum permissible concentration of TSP was fixed in the 2014 year.
It has also be considered, that besides total suspended particles there are many adverse factors with small intensity, which are also risk-factors for development of respiratory diseases. Isolated action of these factors with certain concentrations may not demonstrate any adverse effects on human health, but the combined effect of their action is stronger and obviously will effect general health and specifically - respiratory system.
Implementation of urgent measures for further improvement of the ambient air quality has been recommended, which will be the basis for minimizing the incidence of many chronic diseases.
6. I. TSOMAIA, A.CHANTURIA, D.SYCHEV
THERAPEUTIC DRUG MONITORING FROM THE POSITION OF EVIDENCE-BASED MEDICINE
Department of Pharmacia of Tbilisi Technical University;
Caucasus University, Caucasus Economics and Healthcare School (CHS); Georgia, Tbilisi.
Russian Medical Academy of Continuous Professional Education, Russia, Moscow
J. Experimental and Clinical Medicine, 2017, 3, pp. 24-27
Therapeutic drug monitoring (TDM) is the use of drug concentration measurements in body fluids as an aid to the management of drug therapy for the cure, control or prevention of disease. TDM now has an established place in enabling optimizations of therapy for a tightly defined group of drags. The review describes the practical aspects of TDM to individualize drugs applications for patients with diseases of the internal organs, as there is evidence base the effectiveness in practice.
7. I. TSOMAIA, A. CHANTURIA, D. SYCHEV
CLINICAL INTERPRETATION OF THERAPEUTIC DRUG MONITORING
Department of Pharmacia of Tbilisi Technical University; Caucasus University, Caucasus Economics and Healthcare School (CHS); Tbilisi, Georgia.
Russian Medical Academy of Continuous Professional Education, Moscow, Russia
J. Experimental and Clinical Medicine, 2017, 3, pp. 28-31
Therapeutic drug monitoring (TLM) is very important for optimizing rational individualized therapy in the case of drugs with a narrow therapeutic range, with a good correlation of drug concentration in plasma and clinical effect, and in the absence of clinical efficacy markers. In order for the concentration measurement to be effective, it is necessary that certain sampling criteria in each case be satisfied. These include: the correct wording of the clinical question, the availability of accurate information about the patient (sex, weight, age, liver function, kidney function, drugs used, etc.), sampling of the proper quality, and correct interpretation of the results.
8. V. VACHNADZE, L. KINTSURASHVILI, N. VACHNADZE, T. SULADZE,
V. MSHVILDADZE, K. MCHEDLIDZE
SOME ALKALOID-CONTAINING PLANTS GROWN AND INTRODUCED IN GEORGIA AND THEIR BIOLOGICAL ACTIVITIES
Tbilisi State Medical University, Iovel Kutateladze Institute of Pharmacochemistry, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 31-37
In is discussed a cytotoxic activity of some alkaloid – containing medicinal plants distributed and introduced in Georgia.
Research objects were: Aconitum orientale Mill., A.nasutum Fish. ex Reichend; Chelidoniummajus L., Magnolia Virginiana L., M.officinalis Reher and Wilson; M.grandiflora L., Peganumharmala L., Taxusbaccata; Vincaherbacea W. et K., and V.rosea L. Biologically active substance of alkaloid row were obtained by liquid-liquid extraction method.
Pronounced cytotoxic activity against all tested cell lines (À-549, DLD-1, WS-1) in vitro have shown alkaloids and of the substances: helidoninCh. majus (herba), M. virginiana (cortex), M. officinalis (leaves), P. harmala (seeds), V. rosea (radix).
Specific activity was observed for the alkaloids: protopin, stilopin, alkaloids from Aconitum spp; M.grandiflora (flowers) and T.baccata (needles).
9. G. PARULAVA, D. ZURABASHVILI, M. GARUCHAVA
COLCHIAN BOX-TREE (BUXUSCOLCHICA) ANTI-PATHOGEN PESTICIDES’ IMPACT ON HUMAN HEALTH AND FAUNA COMPLEXES
Georgian State Teaching University of Physical Education and Sport;
Center for Mental Health and Prevention of Addiction, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 37-40
It is proved, that the unique model of Georgian flora, Colchian box-tree (Buxus), is in the ecological catastrophe phase. The chance of survival is minimal in the refuges, gorges and mountain slopes. Relict or introductory plants of all Georgian box-tree species should be sprayed with pesticide “Dimelin” and tilled with fungicides. All types of Deltamethrin (Decis) pesticides must be removed from purging scheme, since, according to the survey results, abovementioned drug is an ecological threat for human health and fauna complexes.
Microstructural investigation of these alkaloid containing medicinal plants have revealed some diagnostic properties, among which can be distinguished the principal structural elements such are: epidermal complex of flaws, leave,s structure type itself and architectural texture composition of transitioned systems of over- and underground vegetative plant organs.
10. B.ZURASHVILI, N.VEPKHVADZE, N.KILADZE, M.GIORGOBIANI, O.MAMATSASHVILI
RADIATION PROTECTION PROBLEMS IN THE RADIOLOGICAL AND NUCLEAR MEDICINE FIELD OF GEORGIAN MEDICAL-PROPHYLACTIC INSTITUTIONS AND THEIR SOLVING WAYS
TSMU, Departments of Hygiene and Medical Ecology and Health Promotion, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 40-42
Radiation safety problems of medical-prophylactic institutions in Georgia have been studied by the Agency of Nuclear and Radiation Safety. Based on the analysis, the relevant recommendations have been established to provide health protection measures for patients and personnel.
11. K. KHAZARADZE, N. JAPARIDZE, R. KHAZARADZE, V. SURGULADZE
THE IMPACT OF THE ENVIRONMENT ON THE HEALTH OF THE GEORGIAN POPULATION
J. Experimental and Clinical Medicine, 2017, 3, pp. 43-44
The paper analyzes the problems of environmental protection in Georgia. Sanitary-epidemiological improvement measures have been developed. The implementation of these measures depends on the unification of the force of different sectors and the state support.
12. D. TSKHOMELIDZE, E. MCHEDLISHVILI, N. CHILADZE
MODERN PROBLEMS OF PARASITOLOGY AND GEORGIA
Tbilisi State Medical University, Department of Medical Biology and Parasitology,
J. Experimental and Clinical Medicine, 2017, 3, pp. 44-47
Our research aim is to estimate in Georgia how frequent are opportunistic diseases, that are mostly recognized as a fatal for immunocompromised organism. Herewith the phenomenon of parasitocenosis should be foreseen - when different combination of parasitic species are found at the same time in human host. According to statistics in Georgian people opportunistic protozoan and helminthic diseases predominate in children, as childhood age is characterized by immature immune system. High percentage index of infected individuals are also revealed from social layers where malnutrition, unhealthy habitat, permanent stress and infectious pathogens affect their immune system. In our opinion, for correcting abovementioned situation primarily it is necessary broadly and permanently inform the society about the existence of parasites and possible dangers from them. We suggest that in this way, even partially, it is possible to protect people that are under particular risk of opportunistic parasites and to preserve the life of infected patients by revealing such parasites in proper time.
13. C.GIGINEISHVILI, M.CHIPASHVILI, Z.KIKVADZE
ENVIRONMENT AND HEALTH
TSMU, Department of Medical Genetics. Tbilisi
J. Experimental and Clinical Medicine, 2017, 3, pp. 48-51
The different fields of the agriculture, to get a good and high quality harvest, are always is always associated with utilization of pesticides. The benefit of pesticides is big, but they cause a real threat to the environment. To serve the aim of population protection, there is great need to study the disorders caused by different kind of pollutes, to develop the ways of prophylaxy and to identify the safe levels.
That was the goal of our study to investigate of one of the most widely used herbicide Paarlan, and its influence on antitoxic effect and amino transferase activity of the liver. As a result were detected the active, utmost safe and inactive strengths of the chemical agent – 8.0; 4.0 and 0.8 mg/kg respectively. The changes caused by chronic intoxication of Paarlan correlate to the dose and exposure time.
14. C. GIGINEISHVILI, E. IMNADZE, Z. KIKVADZE
GENOME EDITING TECHNOLOGY
TSMU, Department of Medical Genetics. Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 52-54
The combination of new unique technologies – CRISPR)-Cas9 and genome drive system enable researchers to edit very quickly and finely the parts of the genome by removing, adding or altering sections of the DNA sequence, even in Humans. CRISPR -Cas9 system consists of two key molecules that introduce a change into the DNA. These are: an enzyme - Cas9, which acts as a pair of ‘molecular scissors’ that can cut the two strands of DNA at a specific location and second is so called guide RNA, and it makes sure that the ‘scissors’ enzyme cuts at the right point in the genome.
The Cas9 follows the guide RNA to cut the undesired sequence section in DNA and in this cut place is substituted with nucleotide chain, brought by CRISPR system.
15. M.KAJRISHVILI, L.LOMTADZE, G.SHAVLADZE, K.KEKELASHVILI, D.KITOVANI
STUDY OF INTERNET ADDICTION AMONG TBILISI SCHOOL CHILDREN
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 54-59
Modern world is unimaginable without computer, but using it incorrectly can result deplorable consequences. Our study was conducted about internet addiction in Tbilisi among school children. There were surveyed 1600 school children. 54% of respondents were female and 46% were male. More than 50% is using internet more than 5 years. 43% uses internet more than 6 hours. It is also important that in late night coefficient of internet users is high in every age group. Most of respondents use the internet for entertainment and communication. Females are leaders in every aspect of using internet. Most of users cannot control time when they are surfing internet. Because of long-term use of internet -41% of respondents had expressed back pain, 39% had eye pain, head ache complains about -21%, 27% - easily irritable, and 38% of them had sleep related problems. From our study we can condole that long term of using internet has unhealthy influence on our health. We believe that promoting youth in sport activities will help to form healthy life style formation.
16 R.JAVAKHADZE, M.TSERETELI, N.KHATIASHVILI, KH. CHIGOGIDZE,
PREVENTION ISSUES OF COMBINED EFFECTS OF CHEMICAL AND
N.Makhviladze Research Institute of Labor Medicine and Ecology, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 57-59
Workers, employed in the mining industry of Georgia, are under the simultaneous influence of physical and chemical factors, which is accompanied by other industrial harmful factors. All this causes in these employees the coexistence of various occupational diseases, such as vibration disease and manganese intoxication, i.e.vibromanganism.
The aim of investigation was the study of preventive questions of the simultaneous chemical and physical factors exposure.
In the simultaneous action of these two factors, there is not only a simple summarize of the pathogenic activity, but also mutual optimization, which leads to a more severe case of occupational diseases than isolated action of these individual factors.
17. I.GVINERIA, M. JURULI, R. JAVAKHADZE, M. TZERETELI, V. SAAKADZE
INCREASING THE LEAD LEVEL IN THE ENVIRONMENT –
THE RISK FOR HEALTH
N. Makhviladze Research Institute of Labor Medicine and Ecology, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 60-62
The toxic effect of lead is considered in the article. The relationship between the amount of lead in the blood and the toxic effects in adults and children is shown. Based on the results of the survey and clinical studies, it was shown that the residents of the areas of intensive transport have more negative health changes compared to those living in suburbs and rural settlements. An increase in the amount of lead in the blood (21.8 μg/dL) compared to the norm (10 μg/dl), minor changes in peripheral blood, nervous and cardiovascular system, and reproductive health indicate the existence of adaptive-compensatory reactions of the body. That is why a thorough and comprehensive study is needed to evaluate the results of the test exposure.
18. N.CHKHAIDZE, M.TURMANAULI, KH.SHUBLADZE, N.RUXADZE,
TATIA TODUA, TEA TODUA
MORBIDITY OF LTD “GIG” GROUP SAKHNAKHSHIRI TKIBULI MINES’ WORKERS ACCORDING TO DAYS OF TEMPORARY DISABILITY
N. Makhviladze S/R Institute of Labor Medicine and Ecology, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 63-65
Extensive and intensive rigorous indicators of morbidity of Ltd “GIG” Group Sakhnakhshiri Tkibuli mines’ workers according to days of temporary disability have been studied in different directions according to E.Notkins international classification. The level of morbidity rate has been assessed as high. It was identified that diagnosed diseases such as industry injuries and poisonings, connective tissue diseases of bone-joints, acute bronchitis, hypertension and circulatory disorders in the brain, kidneys and urinary tract diseases, cardiovascular and other forms of illnesses, other inflammatory diseases of skin and subcutaneous tissue can be considered as occupationally caused diseases.
19. S.MGEBRISHVILI, I.BARBAKADZE, N.KIPIANI
METHOD OF IMPROVING COMPLETE REMOVABLE DENTURE ANCHORAGE, DURING PROSTHODONTIC TREATMENT OF COMPLETE EDENTULISM
Tbilisi State Medical University, Clinical Dental Orthopedics Department; Tbilisi State University, Dentistry and Oral Surgery Department, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 65-67
Prosthodontic treatment was conducted to 70 patients, with diagnosis of postprimary unteethed lower jaw, at the ages from 63 to 84 (43 women, 27 men). Observational group was composed of 24 patients, in main- 46 patients. The basis depth of low jaw prosthesis made for patients of observational group , for oral , vestibular and cheeky side was standard and varied between 2-2.5 mm. As for the main group of patients, the thickness of the prosthesis bases was on the oral and ventral side was 2 mm. Basis from canine to the region of second premolar was thickened to 4-6 mm.
Complete removable denture anchorage made under proposed by us method, which basis thickness from canine to the second is 4-6mm, is characterized with a good anchorage on the edentolous lower jaw, which represents the foundation of improving of chewing strength.
20. N.VEPKHVADZE, B.ZURASHVILI, N.KILADZE, M. KHORBALADZE, T.KOCHORADZE, I.KUGOTI
PREVENTION OF NOROVIRUS FOODBORNE DISEASES
TSMU, Departments of Hygiene and Medical Ecology and Health Promotion, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 67-69
A statistical review of the norovirus infection shows increased incidence of disease in Georgia. The study reveal that the most vulnerable group to this infection are children. Strict infection control practices are necessary to control norovirus spread in schools and kindergartens.
21. N.VEPKHVADZE, M.GIORGOBIANI, N.TSKHOVREBADZE, I.TSKHOVREBADZE, T.KOCHORADZE
INFLUENCE OF CLIMATE CHANGE ON HUMAN HEALTH
TSMU, Departments of Hygiene and Medical Ecology and Health Promotion
J. Experimental and Clinical Medicine, 2017, 3, pp. 72-74
The rate of the climate change associated diseases has been studied. In 2011-2015 it was fixed increased mortality and morbidity rate determined by cardiovascular diseases. New disease “Crimean-Congo fever” was appeared.
There is not direct correlation between climate change and morbidity, but besides this there are many adverse factors which are also risk factors and combined effect of their action will affect general health.
22. D.P. CHIKVILADZE, K.R. TURMANIDZE, D.A. METREVELI, KH.E. GACHECHILADZE, M.L. MIKELADZE
SUSCEPTIBILITY TO THE DIFFERENT GROUPS OF ANTIMICROBIAL SUBSTANCES OF MICROORGANISMS ISOLATED FROM THE ORAL CAVITY DURING PROSTHESING
1Tbilisi State Medical University, Department of Microbiology, 2 LTD “G&N - Denti”, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 75-77
The aim of our study was to determine the sensitivity of microorganisms to different groups of antibiotics. It was shown that currently in our region mainly circulate microbe trains with high level of resistance to some antibiotics. In average, the level of polyresistance (simultaneously to 5, 10 and more antibiotics) ranges from 16,67% to 66,67% of cases. Results of susceptibility/resistance of microorganisms to different groups of antibiotics indicate that isolated microorganisms have relatively high level of resistance to aminoglicosids, cefalosporins, and they are sensitive of modern macrolides, carbophens and ftorchinolones. Resistance study of isolated mikcroorganisms to antiseptics showed that 0,1% “Tantum Verde” and “Eludril”.
23. D. CHITASHVILI, E. KORINTELI, N. BERIANIDZE
The indices of physical and functional data of Georgian national team of judoka before the performances at the European Championship
1Ilia State University; 2Georgian State Educational University of Physical Training and Sports; 3Sports School of Acrobatics; Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 78-81
The recent data of Georgian judoka (girls and adolescents) were studied in the first decade of April, 2017 before the performances at the European Championship. In the training conditions the correlation between the data of locomotor apparatus and relevant functional data was studied. The observations have been conducted at the Central Base of Judo in Tbilisi (Dighomi), where all the conditions for carrying out advanced training are created.
As compared with previous years’ training, these trainings differed in the diversity of athletes. For example, along with the members of Georgian National team the trainings were conducted on more than 100 sportsmen of the both sexes, different ages and the level of training. Among them were: 32 older athletes of the first Georgian National team and their main competitors, 15 athletes aged 15-17, 30 athletes aged 17-20, 12 girls aged 16-18 and 19 adolescents aged 10-12. Basing on the data obtained, the conclusion has been made that at the same loading the functional indices of the athletes of all the ages change individually.
24. N. CHIKVAIDZE, N. KINTRAIA, T. MUZASHVILI, G. BURKADZE
PROBLEMATIC QUESTIONS IN THE DIAGNOSIS OF TROPHOBLASTIC LESIONS
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 81-84
Diagnosis of trophoblastic disease is complex:Includes a clinical-laboratory indications, classical histopathological dates, immunohistochemistry, in situ hybridization and flowcytometry, combining and analyzing which allows to diagnose with high accuracy.
However, generally recognized diagnostic criteria and algorithms are not fully understood, in turn, necessitates the subsequent studying technologies for diagnosing trophoblastic disease, which ultimately contributes to high-precision diagnosis and, accordingly, to the correct management of the patient.
25. G. SULABERIDZE, M. OKUJAVA, K. LILUASHVILI, M. TUGHUSHI, M. ABRAMASHVILI
IMPACT OF DIETARY FIBER ON THE FUNCTIONAL STATE OF GASTROINTESTINAL TRACT AND GENERAL WELLBEING IN PATIENTSWITH CONSTIPATION
Tbilisi State Medical University, *JSC “Curatio”, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 84-89
The pathophysiology of functional constipation, new ways of its prevention and treatment are challenging issues of clinical science nowadays.
The aim of the research was assessment of the impact of supplementation with dietary fiber rich food on digestive feelings, bowel function and general wellbeing in patients with functional constipation. In the study were involved 101 patients with named diagnoses of age from 20 up to 70 years.
Dietary questionnaire revealed significant deficit of dietary fiber in patients with constipation, daily amount was 17.9±5.8g. The dietary supplementation up to the Tolerable Upper Intake Level (UL) (40gr of dietary fiber for patients with functional constipation)was provided with fiber enriched food – bread and muesli, with trade mark “Margi”, containing increased amount of preliminary processed wheat bran. For replenishment of the detected lack of the dietary fiber the patients were prescribed to take 100-300g of bread and/or 40-110g of muesli at usual breakfast. The adopted clinical assessment questionnaire was applied for evaluation of bowel function, digestive feelings and general wellbeing.
Research data reviled that introduction of dietary fiber rich bread and muesli for making up the daily amount of consumed fiber is well tolerated by the patients, rapidly and permanently improves the bowel function and general wellbeing, is not associated with digestive complains and significantly decreases use of laxatives.
26. M.S. TSITSKISHVILI, G.V. KARCHAVA, M.V. ADVADZE, E.T. PETRIASHVILI, E.P. ESEBUA
ATMOSPHERE SELF-RECTIFICATION FROM AEROSOLS
Sokhumi State University Faculty Natural Science and Healthcare, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 90-92
“Self-rectification’s velocity”, dry “sedimentation” and “washing” by atmospheric sediments. For different climatic regions and seasons, the values of the developed parameter that is of great importance for ecologically sound atmospheric protection.
27. N. TSKIMANAURI, N. KHACHAPURIDZE, P. IMNADZE, N. GELADZE, S.BAKHTADZE
STUDY OF NEURODEVELOPMENTAL DISORDERS IN THE PERINATAL RISK GROUP OF CHILDREN UNDER 2 YEARS
¹Tbilisi State Medical University; ²Neurological Clinic LTD “Valeo”; ³Iv. Javakhishvili Tbilisi State University; 4National Centre For Diseases Control, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 93-97
Neurodevelopmental disorders affecting cognitive and behavioral domain of child development as well as speech and language can lead to various degree of thier physical and intellectual disabilities. In developing countries 43% of children aged 5 years or less are at high risk of neurodevelopment delay.
According to numerous studies neurodevelopmental disorders can be caused byvarious prenatal factors: maternal diseases, pregnancy disorders leading to behavioral disturbances and brain malformations. Perinatal infections and neonatal sepsisare considered as high grade risk factors. According to recent literature environment also plays a key role in etiology of neurodevelopmental disorders. For intance, such air pollution with methyl mercuri and organic compounds can have significant negative impact of pregnancy course, also CO is considered to cause variuos types of cortical malformations.
Children born with multiple dysmorphisms and behavioral disorders face to the stigma, isolation and discrimination. Problem neglect leads to leaving this challenging issue without attention which causes high rate of disability and mortality among these children.
28. R. VEKUA
RADIATION INFLUENCING EXAMINATION ON GENETIC APPARATUS OF EXFOLIATIVE BUCCAL CELLS BY USING MICRONUCLEUS TEST
Iv. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 98-100
Were studied radiation influencing on genetic apparatus of exfoliative buccal cells of mouth cavity by using micronucleus test for Sachkhere district villages – Sareki and Argveti2 s population. For assessment of ionizing radiation impact this method was used in oncologic patients. In all examined group observed negative influence of radiation on genetic structures, which evidenced morphologically by formation of micronucleus and by changing of their amount.
29. G. ORMOTSADZE, E. TIKARADZE, R. KVERENCHKHILADZE, G. SHARASHENIDZE, T. SANIKIDZE
ASSESSMENT OF SPATIAL HETEROGENEITY OF CANCER MORBIDITY IN THE SACHKHERE REGION OF GEORGIA
Iv. Beritashvili Center of Experimental Biomedicine, Tbilisi State Medical University, Sachkhere District Hospital, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 101-103
In order to assess the spatial heterogeneity of the cancer morbidity in the Sachkher region, a comparative analysis was made of the incidence of morbidity at the level of the administrative-territorial division of the district. Data was provided by the administration of the Sachkhere District Hospital. Standardized incidence rates for each individual location were compared. A significant spatial heterogeneity of the oncological morbidity in the territory of the region has been revealed, the identification of the causes of which is the subject of further research.
30. M. SHERVASHIDZE, K. BARABADZE, A.TSABUTASHVILI
TROPONIN I AND NO LEVEL IN CHILDREN WITH CARDIO-RESPIRATORY PATOLOGY
D.Tatishvili Medical Centre; Iv. Javakhishvili Tbilisi State University;
Batumi Shota Rustaveli State University, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 104-106
Cardiac troponin I – is relatively specific and sensitive biomarker of cardiac injury.
Cardiac injury can be defined as the disruption of normal cardiac myocyte membrane integrity resulting in the loss into the extracellular space of intracellular constituents including detectable levels of a variety of biologically active cytosolic and structural proteins such as troponin. Injury is usually considered irreversible (cell death). When a sufficient number of myocytes have died (myocyte necrosis) or lost function, acute clinical disease is apparent.
84 patients were observed. They were divided into two groups – Group 1: children with cardio-respiratory pathology and Group 2: control group with generally healthy children. In the study NO level was usually increased and it was higher than in control group. The study allowed to use investigated markers as the diagnostic criteria of cardiovascular damage to reveal the highrisk groupin children with cardio-respiratory pathology, as they truly represent the candidates for future meaningful damage to cardiovascular system, which will require further monitoring of clinical and laboratory parameters and include prevention activities in their lifestyle.
31. ROGHIEL BAGHERZADEB AKBARI
A BRIEF HISTORY OF MEDICAL PHYSICS IN IRAN
Retired Academic member of Tehran University
Health Physicist, Radiation Protection and Medical Physicist, Tehran, Iran
J. Experimental and Clinical Medicine, 2017, 3, pp. 106-111
In my view, one can say, that, the activity of Medical Physics in Iran, was started to improve, with the establishment of the Tehran University Nuclear Centre (TUNC), in 1958-1959.
By the Financial and Training assistance of the IAEA to the TUNC, and Training and Research Courses, of CENTO, at Tehran University, hundreds of personnel were specialized in different branches of the applications of radioisotopes, such as: Medicine, Science, Agriculture, Industries, and so on… For the first time, the film badge service, and Radiation protection control, according to the ICRP recommendations and regulations were applied to radiation users and sites, all over the country.
At present, we have Medical Physic departments in most hospitals, and we have hundreds of Medical Physicists in our “Iranian Association of Medical Physics” (IAMP), which is active since 1991.
32. N.PRUIDZE, R.KHETSURIANI, A.SHUKAKIDZE, M.KHAREBAVA, L.ALADASHVILI, T.SANIKIDZE
INFLUENCE OF AGE ON RED BLOOD CELLS’ TOLERANCE
J. Experimental and Clinical Medicine, 2017, 3, pp. 111-113
The purpose of the study was determination of the viability (tolerance) of red blood cells in different age groups volonters stored at the different temperature conditions (room temperature, +50C and -170C). As rhe result of the study it was found that the aging volunteers’red blood cells are much more resistant (tolerant) compared to the yang volunteer‘s red blood cells, which are suffered by hemolysis that is manifested by reducing of their number.
33. N.GARUCHAVA, M.KUPARADZE, I.AVALIANI, M.SVANIDZE
THE ROLE OF COPPER IN SHA PING THE ENDEMIC GOITER
J. Experimental and Clinical Medicine, 2017, 3, pp. 114-119
Except iodine deficiency in the etiology of endemic goiter play an important role some other microelements, vich called goitrogens, or strumogenes. One of important microelements is copper. In opinion some authors deficiency of copper in environment has a role in etiology of endemic goiter, in other scientists opinion the main cause of endemic goiter is copper toxicity. Such different opinions allow to draw conclusions that It is nessesary in-depth investigation environmental objects for study of full spectrs of etiological factors of endemic goiter in each region.
34. T.KOBIDZE, S.GVIDANI, TS.SUMBADZE, N.METREVELI, S.MARKARIAN
INFLUENCE OF PHENOL VAPOR INTOXICATION ON CYCLIC NUCLEOTIDES AND PROSTAGLANDINS RATIOS
A.Natishvili Institute of Morphology, I. Javakhishvili Tbilisi State University; Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 120-123
In our experiments we studied the dynamics and the mechanism of change in cyclic nucleotides and some groups of prostaglandin’s concentration under the intoxication by phenol vapor. The experimental data indicate that after the inhalation by phenol vapor activation of cyclic nucleotides is directly proportional to the hormones secretion second messengers of which they are. In particular, the high concentration of c-AMF in lethal group is caused by elevated level of PgA and PgE, so as the increase of c-GMF is a result of elevated concentration of PgF2α. Accordingly, in group of survived animals - the organism passed on unsparing regiment and secretion of prostaglandins is carried out in little amounts, conditioning low levels of cyclic nucleotide’s concentration.
35. L.GUBELADZE, D.GOGIASHVILI, S.RIGVAVA, M.NATIDZE, T.KOKASHVILI,
COMPARATIVE BIOLOGICAL CHARACTERIZATION OF PHAGES SPECIFIC TO B.ANTHRACIS, ISOLATED FROM ENVIRONMENTAL SOURCES IN GEORGIA. COMMUNICATION 1. B. ANTHRACIS –SPECIFIC PHAGES ISOLATED
IN GEORGIA IN 2008-2009
G.Eliava Institute of Bacteriophages, Microbiology and Virusology, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2017, 3, pp. 123-129
Five bacteriophages active to B.anthracis - BaGD, BaKt1, Ba Kt2, BaKu1 and BaKu2 have been isolated in 2008-09 from environmental sources in Georgia. By virion morphology all 5 phages belong to Syphoviridae family, representing specific submorphotypes of gamma phage family and show diverse serologic characteristics. The studied phages demonstrated species-specificity and broad lytic spectrum within the species, that indicates their potential for identification of B.anthracis and differentiation from closely related species, also for subtyping of B.anthracis populations.
Acknowledgment. The presented work was in part supported by the grant STCU P486.