J.EXPERIMENTAL & CLINICAL MEDICINE
2019, ¹ 4
1. VEPKHVADZE N., ZURASHVILI B., KHORBALADZE M., KILADZE N.,
KUGOTI I., KOCHORADZE T.
DYNAMICS OF INFECTIOUS AND PARASITIC DISEASES IN GEORGIA
FROM THE VIEW OF CHANGES IN ECOLOGICAL FACTORS UNDER GLOBAL WARMING
TSMU, Departments of Hygiene and Medical Ecology and Health Promotion, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-9-12.
The impact of environmental changes on the spread of infectious and parasitic diseases in Georgia under global warming has been studied. For this purpose, statistical data on morbidity and incidence of infectious and parasitic diseases of the National Center for Disease Control and Public Health (2002-2017) has worked out.
Dynamics of infectious and parasitic diseases in 2008-2017 is characterized by a high increase and in a decade, their frequency has almost doubled. The reason presumably is the increase in precipitation and humidity due to global warming, which contributes to the activation of the biological cycle of different microorganisms in the form of hybrid varieties. And this is manifested in increasing number of diseases, including infectious and parasitic.
In order to improve the situation, it is necessary to inform all groups of the population about the global changes in the environment, the health risks caused by these changes and relevant preventive measures.
2. N.VEPKHVADZE, N.TSKHOVREBADZE, I.TSKHOVREBADZE, T.KOCHORADZE, I.KUGOTI
CANCER RATE AND PREVENTION IN GEORGIA
Tbilisi State Medical University, Departments of Hygiene and Medical Ecology and
Health Promotion, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-12-15.
Given research focuses on data of onco-epidemiological situation in Georgia in 2013-2017, on the basis of which was determined change of morbidity pattern.
The data were taken from NCDC. The research found, once again, that Georgia belongs to the countries with comparable high rate of oncological morbidity and mortality. The latest statistic shows that, respiratory system cancer and breast cancer are the leading types and their rate of incidence is still increasing.
To improve onco-epidemiological situation complex approach is important, which implies increased awareness of population and health care services professionals, maintaining a healthy lifestyle, avoiding exposure to known cancer-causing substances, early identification of the disease etc.
3. I.CHKHIKVISHVILI, N.GOGIA, V.ESAIASHVILI, D.CHKHIKVISHVILI
ANTIOXIDANT ACTIVITY AND POLYPHENOLIC COMPOUNDS IN
DIFFERENT FRACTIONS OF CORNMEAL
TSSU, V.Bakhutashvili Institute of Medical Biotechnology, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-15-20.
Biologically active compounds present in the membranes of the grains are able to neutralize oxidative stress and reduce the risk factor for many chronic diseases. We found that the fractions of corn formed during the grinding of grains differ from each other in terms of the activity of antioxidants and the amount of polyphenols. It is known that the smaller the fraction size, the greater the amount of extractive substances goes into solution. Despite this, more polyphenolic compounds and antioxidant activity are present in larger fractions.
According to our conclusion, the reason is the greater amount of useful substances in the large fraction of corn, which is present in it from the shell of grains. The coarse fraction is distinguished by its good health qualities, which we recommend to use in the form of hominy (Gomi), Georgian dishes characteristic of the regions of Mengrelia.
4. N.CHOMAKHASHVIL, K.PRANCHUKI, G.ORJONIKIDZE, L.KATAMADZE, Z.CHOMAKHASHVILI
ERGONOMICS IN DENTISTRY
D.Aghmashenebeli Georgian University, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-20-28.
The authors discuss literary data on ergonomics in detail, which includes the doctor’s health operating field lighting, vibration, microclimate, noise and other factors, and ultimately concluded that the ergonomics principles in dentistry is of particular importance, since there is no other medical field where the external factors and the working conditions of doctors and support staff have an impact on health. In this regard, studying and analyzing the conditions in which Georgian dentists are practicing in the industrial cities of Georgia and practical recommendations developed on the basis of this research, which can improve them, is of great practical importance at this socio-economic stage of our country’s development. Moreover, the studied literature does not show the interest of both Georgian practitioners in the field of dentists and the ergonomics of scientists, as we have not found any valuable work done by them in the research process.
5. SH. ZARNADZE, I. ZARNADZE
ROLE AND IMPACT OF ECOTOURISM ON NUTRITIONAL BEHAVIOR AND HEALTH STATUS
Tbilisi State Medical University, Department of Nutrition and Aging Medicine, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-28-30.
The link between food and health is a delicate balance between diet and health. Experts explain that food chain analysis, aimed at identifying existing vulnerabilities and assessing, producing and consuming environmental impacts, is a good practice, with individual and collective lifestyles having a positive impact on the environment and resources. Individual food intake, for the purpose of developing diets, is sustainable for both the individual and the ecosystem. The choices we make about the foods we eat are crucial to the well-being and ecosystem in which we move and have a significant impact on our quality of life today and in the near future.
6. E.KVINIKADZE, T.SHENGELIA, G.SULAKVELIDZE, G. KVINIKADZE
PRP-THERAPY, AN ECOLOGICAL METHOD FOR THE TREATMENT OF OSTEOARTHRITIS
Cardiology Hospital of Tbilisi, Department of Human Ecology, Tbilisi, Georgia; Mechnikov University Orthopedic Clinic, St.-Petersburg, Russia
J. Experimental and Clinical Medicine, 2019, 4, pp-30-33.
The results of the literature review and our own experience confirm the efficacy of PRP therapy in patients with spondyloarthritis, gonarthrosis, coxarthritis. Removes pain in the knee joints during stage 1 and stage 2 gonorrhea. I grade 3 gonorrhea significantly reduces pain and enables patients to regain their ability to move and work. Platelet-rich plasma has been shown to stimulate tissue self-regeneration. The best results are achieved in the first and second stages Remission lasts for 1 year. In the third stage, surgical treatment may be delayed. The fourth stage of arthrosis is an indication of endoprosthesis.
7. 1M.BULEISHVILI, 1,3,4M.KANTARIA, 1K.KAKABADZE, 3N.OTARISHVILI,
1N.PAVLIASHVILI, 1T.SANIKIDZE
SOME ASPECTS OF PATHOGENESIS OF ESSENCIAL HYPERTENSION
1Tbilisi State Medical University; 2David Aghmashenebeli University of Georgia; 3Acad. N.Kipshidze Central University Clinic; 4University “Geomedi”; Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-33-37.
Arterial hypertension is very actual problem in developed industrial countries. It is a common cause of heart failure, cerebral stroke, and myocardial infarcts. Hypertension usually reveals in with aging.
Many pathophysiological factors are involved in the hypertension pathogenesis of hypertension: activation of sympathetic nervous system, hyperproduction of sodium-dependent hormones and vasoconstriction, alterations in renin-angiotensin-aldosterone secretion, reliase of vasodilators (prostatycline, nitric oxide (NO) and natriuretic peptides), violation of kallikrein-kinin system expression, disorders of blood vessels resistant lesions, diabetes, insulin resistance, obesity, activation of vascular growth factors, changes in the adrenergic receptor, disorders in cellular ion transport mechanisms.
8. 1T.KOBIDZE, 2I.AFANDIYEV, 3O.GERZMAVA, 4M.KERESELIDZE
The Comparative Structure of Acute Poisonings in Georgia
and Azerbaijan
1Association of Clinical Toxicologists of Georgia; 2Azerbaijan Medical University, Baku;
3Grigol Robakidze University, Tbilisi, Georgia; 4National Center for Disease Control and
Public Health, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-37-45.
Objective. According to WHO, acute poisoning is one of the important public health global problems. At the same time, each geographic region is characterized by a unique epidemiological situation on acute poisoning. The aim of this study was to investigate and compare the main toxic-epidemiological parameters of the two largest cities of the South Caucasus - Baku and Tbilisi, and on the basis of the obtained data to develop a program on chemical safety and prevention of acute poisoning among population of the region.
Methods. Data on all acute poisoned patients undergoing in-patient treatment in the hospitals of Baku and Tbilisi in 2009-2016 were placed in the standard forms and subjected to a comparative analysis. Diagnoses of toxicological patients were unified in accordance with ICD-10 (T36-T65). The total number of patients in this study was 13,292 in Baku and 14,229 in Tbilisi.
Results. The results of the study showed that in the both cities among toxicological hospitalizations dominated by cases of toxic effects of substances chiefly nonmedicinal as to source (62.13% in Tbilisi and 53.75% in Baku). However, with a detailed analysis of individual nosological units, we found significant and fundamental differences in the toxic-epidemiological profile of non-medicinal chemical poisoning in two capitals.
For example, acute alcohol poisoning in Tbilisi was accounted for 24.26% of all intoxications, or 39,865 cases per 100,000 population. At the same time, alcohol intoxications in Baku were significantly less frequent, amounting to 4,454 hospitalizations per 100,000 population or 5.73% of all poisoning cases.
Corrosive substances poisoning in Baku amounted 10.77% of all intoxication, while in Tbilisi it was significantly less -3.86%.In Baku, the hospitalizations rate of acetic acid poisoning was 5.724 cases per 100.000 population, while in Tbilisi it was only 0.023 cases per 100.000 inhabitants.
Toxic effects of carbon monoxide in Baku occupied 24.36% and in Tbilisi - 4.53% of all poisoning cases, which was 18.951 and 7.449 hospitalizations per 100.000 population, respectively.
According to pesticide poisoning, hospitalization rates in Baku was 2,710 and in Tbilisi 6,906 cases per 100,000 population.
Hospitalization of patients with envenomation in Tbilisi amounted to 5,901; and in Baku - 2,622 cases per 100,000 residents, respectively.
In general, the hospitalization rate of intoxication with substances chiefly nonmedicinal as to source use in Tbilisi was 102,088 cases per 100,000 population, and in Baku - 41,817 cases per 100,000 residents respectively.
Conclusion. This prospective toxic-epidemiological study revealed a significant incidence of acute intoxication in the two largest cities in the South Caucasus. However, there are considerable differences in the comparative profile and frequency of hospitalizations in patients with acute poisoning in Baku and Tbilisi over the period 2009-2016. The observed cases of mass and unusual intoxication during the study period make it necessary to create the unified network for the monitoring toxic-epidemiological situation and rapid information exchange on emerging toxicological risks in the South Caucasus region.
9. G.LILUASHVILI, I.ZARNADZE, SH.ZARNADZE, L.LOMTADZE, D.KITOVANI,
L.BARAMIDZE, D.TABIDZE, M.KAJRISHVILI, Z.SIKHARULIDZE
MILITARY HEALTH, MILITARY SERVICE AND ECOLOGICAL SAFETY
Tbilisi State Medical University; Department of Public Health Management,
Policy and Economics, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-45-47.
Ecological security has a universal definition as it applies to the whole of our planet, and especially to states and regions, in certain types of economic, military, or other actions. Ensuring environmental security during the daily operations of troops is a key part of security and if the requirements are not met then they can be harmed instead of protecting people. For the past two decades, Western militaries have been experiencing an increase in domestic environmental regulation. But, as with all major entities, the institutional inertia of adopting environmental standards is a significant barrier to change, even when environmental sustainability has the benefit of success.
10. I.KORINTELI1, H.PAGAVA2, K.PAGAVA1
PECULIARITIES OF BACTERIOPHAGES USE IN CLINICAL PRACTICE
1Child and Adolescent Medicine Department; 2Department of Epidemiology and Biostatistics,
Tbilisi State Medical University, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-47-51.
Infectious diseases are one of the most common causes of morbidity worldwide.Despite the scientific and technological advances of the 21st century, the mortality rate of infections remains high.Inappropriate use of antibiotics in recent years has particularly increased the number of antibiotic-resistant strains. Bacteriophage is a virus, which has an ability to destroy a bacterial cell, including antibiotic-resistant strains. Bacteriophage is considered as an alternative treatment for respiratory and gastrointestinal infections. Therefore, it will be very informative to identify the features of bacteriophage use in clinical practice.
The aim was to study bacteriophage use in clinical practice in Georgia by various physicians. A questionnaire was used to assess the bacteriophage use. Overall 200 acting physicians were interviewed. 71.2% of respondents use phage in clinical practice. Most frequently are being used pyobacteriophage (43.1%) and intestiphage (32.3%) Most of them treat adults. However, as expected, phages are used more extensively in pediatrics. The phages are mainly used for treatment of respiratory and intestinal infections. Commonly doctors prescribe a phage whithout antibiotic which is a positive trend. 38.2% of physicians assessed the efficiency of the phage as 5 out of 5 (4.7% assessed it as 1 out of 5). It has been shown that in order to improve phagotherapy it is important to increase phage availability, reduce prices, develop national guidelines and provide more information about bacteriophages.
11. N.KURDIANI, A.BAKURIDZE, N.TSAGAREISHVILI, N.KSOVRELI, G.MIKAIA
BIOPHARMACEUTICAL ASPECTS OF RECIPE AND TECHNOLOGY OF STEVIA TABLETS
Tbilisi State Medical University Department of Pharmaceutical Technology, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-51-55.
The purpose of this research is to determine stevia tabletscomposition and develop technologies for manufacturing. The influence of excipients on the mass and technological processes of effervescent stevia tablets was determined on the basis of biopharmaceutical studies. It was experimentally proved optimal technology for the effervescent stevia tablets by wet granulation method.
12. T.MAMINAISHVILI, N.KOMAKHIDZE, I.CHKHIKVISHVILI, NANA V.KIPIANI, M.ENUKIDZE, M.MACHAVARIANI, T.SANIKIDZE
ANTIINFLAMMATORY EFFECT OF GEORGIAN CROPS EXTRACT ON ORAL CAVITY
Tbilisi State Medical University; Bakhutashvili Institute of Medical Biotechnology
David Aghmashenebeli University of Georgia, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-55-60.
The purpose of the study was investigation of the effectiveness of the extracts from Georgian crops for the treatment of oral cavity inflammation in the patients with leverage system (to correct the deformation of the jaw-teeth system).
The patient’s oral cervical condition has been studied after 6-8 months after installing the leverage systemby by Schiller Pisarayev, Papillo-Margone-Alvolar Index PMA and oral hygienic index before and after 10 days using of the examined extract.
Based on the analysis of the obtained results, we can conclude that the excavation made from the Georgia’s legumes extract was characterized by far more powerful anti-inflammatory effects compared to standard deviations. This allows us to recommend this extract to treat inflammatory processes of oral cavity tissues.
13. M.PETRIASHVILI, L.ZHORZHOLIANI
THE PRE- AND PERINATAL PREDICTORS OF ATOPIC DERMATITIS IN EARLY CHILDHOOD
I.Javakhishvili Tbilisi State University, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-60-67.
The aim of the research was to identify the pre- and perinatal risk factors for developing the atopic dermatitis in early childhood and study their predictive value.
In the process of retrospective study there were investigated 68 patients from 0 - 2 years of age suffering from atopic dermatitis. As many as 55 children, who have not developed the allergic pathology, were included in the control group.
There were outlined the following factors having the high predictive value: the low earned income of a family (OR – 3.17), the poor living conditions (OR – 4.94), the high frequency of respiratory diseases (OR – 6.87), sinusitis (OR – 9.54) and bronchitis (OR – 6.87), in mothers; the occurrences of food allergy (OR – 7.35), atopic dermatitis (OR – 6.00) and drug allergy (OR-7.22) in mothers; as regards the pregnancy complications – vomiting (OR – 2.32) and the antibiotic treatment having been administered during pregnancy (OR – 3.29).
The knowledge of pre- and perinatal risk factors assumes the great importance for a decrease in the negative impact on the fetal organism and, accordingly, from the perspective of preventing the atopic dermatitis in early childhood.
14. KK.KAKABADZE, I.MEGRELADZE, T.SANIKIDZE, NINA V.KIPIANI, N.KHVICHIA,
N.SIKHARULIDZE, L.GUMBERIDZE, I.KVACHAKIDZE, N.MITAGVARIA
MORPHOLOGICAL CHANGES IN THE TARGET ORGANS OF HYPERTENSION IN AN EXPERIMENTAL MODEL OF HYPERTENSION IN RATS
Tbilisi State Medical University; I.Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-67-71.
The purpose of the study was to determine morphological changes in the target organs of arterial hypertension, in an experimental model of hypertension in rats.
The study was performed in 21 white experimental male rats, weighing 200-220 grams.
For inducing arterial hypertension in rats, L-NAME was intraperitoneally administered daily at 40 mg/kg for four weeks. The morphological changes in the heart, kidney and brain in rats were studied of L-NAME administration over four weeks period and after three weeks.
Based on analysis of the obtained results have shown that in an experimental model of hypertension, developed after a long (four weeks) administration of NO-synthase inhibitor, blood pressure increased from 88,57±19,86/63,92±16,95 mmHg to 186,07±14,38/106,38±18,05 mmHg (p<0,05). After three weeks, blood pressure returned to baseline. The results of the experiment show, that arterial hypertension, developed in NO deficiency is reversible, but it causes of the left ventricular hypertrophy, overflow of blood vessels and local hemorrhages, sclerotic changes in the blood vessels walls of the right and left kidney.
15. D.CHITASHVILI, E.KORINTELI, N.BERIANIDZE
The goals of sports professional orientation and means of its implementation
Ilia State University, the Georgian State Teaching University of Physical
Education and Sports, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-71-74.
The proper choice of sports professional orientation at the initial stage of physical exercises and its implementation in sports activities requires taking into account many complex issues. The research was conducted in the school of general physical training. The study of motor and functional capacities and their interrelation in 6-10 years old children is presented in this work. Our research gives us the possibility to offer some recommendations to children and their parents for future professional orientation of sports.
16. N.PAVLIASHVILI, M.BULEISHVILI, T.SHARASHENIDZE, N.OTARISHVILI, M.MACHAVARIANI, M.ENUKIDZE, T.SANIKIDZE
SOME MECHANISMS OF ADRENERGIC REGULATION OF BLOOD T LYMPHOCYTE’S FUNCTION
1Tbilisi State Medical University; V.Bakhutashvili Institute of Medical Biotechnology;
3Acad. N.Kipshidze Central University Clinic; 4University “Geomedi”; Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-74-78.
Numerous neurotransmitters and neuropeptide receptors, including β-adrenoceptors, have been seen on the membrane of blood T lymphocytes. Many studies confirmed the important role of T lymphocyte beta-adrenal receptors disorders in the pathogenesis of various diseases.The aim of the study was to identify some of the mechanisms of adrenergic regulation of blood T lymphocyte function.
Research has been carried out on human leukemia transformed mature T cells (Jurkat cells) (DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen (Germany)). We determined the viability of Jurkat cells incubated with and without phytohemagglutinin A (PHA), and non-selective β-adrenoceptor agonist, isoproterenol, and antagonist, propranolol.
Phytohemagglutinin A (PHA) increased the viability of Jurkat cell by 20%. The β-adrenoceptors agonist, isoproterenol, did not affect the viability of intact Jurkat cells, whereas. In the case of stimulation of the Jurkat cells with mitogen (PHA) increased their viability by 12%. The β-adrenoceptors antagonist propranolol reduced the viability of both, intact and mitogen (PHA)-stimulated Jurkat cells by 20% and 40%, respectively. In the paper, the mechanisms of action of the β-adrenoceptor antagonist and antagonist on the Jurkat cells’ membrane β-adrenoreceptors are discusses. In view of the foregoing, it is necessary to take into account any possible potential disorders affecting the immune system during the use of β-adrenoceptor modulators in the treatment of various diseases.
17. K.KHAZARADZE, N. JAPARIDZE, V.SURGULADZE
HEALTH EFFECTS OF CANNABIS (MARIJUANA)
Georgian State University of Physical Education and Sport; Tbilisi State Medical University;
Caucasus University; Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-78-80.
The paper analyzes the attitude of young people (sportsmen) towards Cannabis in Georgia.In the work there is a great place to note that consumption of Cannabis is harmful, and in many cases it is devastating for active athletes,as for former sportsmen. Our survey had showed that consumption of Cannabis is one of the means to overcome the depression and to feel happy. This is not true, and vice versa leads to dependence and personal degradation.
18. E.MIRVELASHVILI, E.KIKACHEISHVILI
ETIOLOGICAL STRUQTURE OF BACTERIAL PROSTATITIS (THE ANALYSIS OF 85 CASES IN 2018)
Tbilisi State Medical University, Department Public Health, Health management, economical and policy, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-80-82.
The bacteriological and mycological investigations of prostate gland juice were carried out in the pacients with chronic prostatitis. As a result of the investigations it has been revealed that TRV was grown up in 92,6%, C.albicans – in 46,1%, S.aureus- in 58,7%, S.epidermidis- in 19,5% and E.fecalis – in 8,6%.
The results of our investigations have showed that on the same level as antibioticotherapy, antitrichomonas andanticandida drugs should be used for the treatment of prostatitis in our region.
19. N.KVIZHINADZE, T.CHUMBURIDZE
DEVELOPMENT OF PHARMACEUTICAL CARE PERSPECTIVES IN GEORGIA
Tbilisi State Medical University, Department of Social and Clinical Pharmacy, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-82-84.
Aspects of pharmaceutical care are best developed in Georgia at the pharmacy level, but there is very little public awareness of what kind of assistance a pharmacist can provide. Taking care of the health of each individual patient is a key task of modern pharmacy, which has led to the development of a separate direction – pharmaceutical care. The development of this area of pharmacy has made drug treatment safer and more effective, increasing patients’ awareness of both their own treatment and ways to prevent certain diseases.
20. N. KVIZHINADZE,. M. TSIMAKURIDZE
DEVELOPMENT OF HEALTH CARE POLITICS SYSTEM IN GEORGIA
Tbilisi State Medical University, Department of Social and Clinical Pharmacy
J. Experimental and Clinical Medicine, 2019, 4, pp-84-86.
Significant socio-economical changes in Georgia over the last 10 years have had an impact on overall health care, and in particular on pharmaceuticals, which has undergone a total transformation as a result of reforms. New rules, regulations, state control systems, and new patient compensation mechanisms are being introduced. Currently, the pharmaceutical sector, as an important link in the healthcare system, is entering a new phase of its development. This development is viewed on the basis of common principles, not only in view of the transitional period in our country’s economy, but also in view of the global changes in the health care system that have been reformed as a matter of priority.
21. N. KVIZHINADZE
GENERAL DRUGS AND CHANGING ASPECTS IN THE PHARMACEUTICAL ACTIVITY
Tbilisi State Medical University, Department of Social and Clinical Pharmacy, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-86-87.
OVERVIEW. The money paid for medical care and treatment by the population in Georgia is significantly higher than the average family’s financial capacity, which places a heavy burden on the population and especially on the poor. An analysis of the 2012 Utilization and Expenditure Survey revealed that more than 40% of the population’s spending on non-food products comes from healthcare (non-household spending is total household expenditure excluding food expenditure).
Particularly emphasized by this study is the fact that much of the cost of healthcare is determined by the cost of medicines.There has been a significant increase in the prices of medicines in the pharmaceutical market for several years now, given the fact that the country lacks a mechanism and tool to regularly identify key and important features of the pharmaceutical market (both price, geographic and financial availability, etc.).
The rising costs of health care and the insecurity of the population on the agenda highlights the need for public and public debate on drug price hikes, on the one hand, and the creation of mechanisms and legislative environments that promote equal access to medicines for all strata of the population. Providing.
This study is a still unexplored field that has the potential to provide policy makers with recommendations that will guide them in the right direction for specific interventions. In particular, there is no legislative framework in Georgia that regulates the practice of prescribing medicines (except for insurance doctors).
This research serves the main purpose of reducing the cost of treatment for the Georgian population and equal access to medicines for all segments of the population. The latter is uniquely important for the country, as the analysis of health services utilization and spending research shows that high health care spending is one of the factors contributing to poverty. However, an in-depth analysis of health research shows that one of the factors contributing to these catastrophic costs is the presence of a patient with a chronic illness in the family. The cost of treating a chronic illness is a medical expense.Increasing physical access and demand for generic medicines should become one of the top priorities of state policy.
As we have noted, the issue in Georgia has not been studied so far, which further illustrates the relevance of the current research.
22. D.KOBESHAVIDZE, M.GIORGOBIANI, G.NIZHARADZE, L.KHARABADZE
THE CASE OF SUCCESSFUL PERINATAL MONITORING OF GASTROSHISIS
Ltd “Clinic Imedi”, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-87-90.
Identification and radical treatment of rare birth defect – gastroschisis, was presented.
Fortunate outcome of this clinical case was achieved due to following factors: a) Precise antenatal identification of this birth defect by ultrasound and planning of the term and type of labour; b) Absence of concomitant birth defects and injures (intestinal atresia; megacolon; ,,short gut’’); c) Prompt, precise and thorough steps of departments of critical medicine and surgery (resuscitation measures, preparing for operation, high quality operative tecnicue).
The direct interrelation of successful management of similar cases with minimal duration of preoperative period confirms the reality, that obstetrician and neonatal departments must be situated within one medical area. ,,Imedi Clinic’’ demonstrates the successful sample of such coexistence and cooperation.
23. K.MANJGALADZE, G.TEVDORASHVILI, T.ALIBEGASHVILI, M.KHORAVA, G.BURKADZE
DISTRIBUTION OF NK CELLS IN MICROENVIRONMENT DURING THE PROGRESSION OF CERVICAL INTRAEPITHELIAL NEOPLASIA
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2019, 4, pp-90-95.
Microenvironment plays central role in the development of cervical precancerous and cancerous lesions. Cervical intraepithelial neoplasia (CIN) represents a group of precancerous lesions, divided into three degrees. We investigated the distribution of NK cells different grades of CIN. We analysed NK cell marker CD56. In addition, we investigated the proliferation marker Ki67 and apoptotic marker BCL2. The results of our study indicated that grade I CIN which subsequently progressed into grade II CIN was characterised with low NK cell infiltration, high proliferation index and low apoptotic index. Similar results were seen in cases of CINII which were later progressed into CINIII or in carcinoma. Therefore, we would like to recommend the analysis of microenvironment alterations and particularly NK cells in CIN lesions, in order to assess their progression potential.
24. V.MUNJISHVILI1, E.BARABADZE1, T.MUZASHVILI1, M.GACHECHILADZE2, G.BURKADZE1
IMMUNOHISTOCHEMICAL PHENOTYPE OF OVARIAN MUCINOUS BORDERLINE TUMORS
1Tbilisi State Medical University, Georgia; 2Palacky University Olomouc, Czech Republic
J. Experimental and Clinical Medicine, 2019, 4, pp-95.97.
The aim of our study was to investigateimmunohistochemicalphenotype of ovarian mucinous borderline tumors, compared to mucinous cystadenomas and low and high grade mucinous carcinomas.Altogether,80 formalin fixed and paraffin embedded tissue specimens, distributed in four groups, including mucinous cystadenoma (group I), mucinous BOTs (group II), Low (group III) and high (group IV) grade mucinous carcinomas,were investigated by standard immunohistochemistry, using antibodies against CK7 CK20, WT1, Vimentin, CDX2, CEA, ER, cyclin D1, BCL2, E-cadherin,calretinin, ÑA125, Ki67, P53.
Study results showed, that ovarian mucinous BOTs are characterised with highly variable immunohistochemical phenotype and the use of multiple immunohistochemical markers are recommended for the differential diagnosis from low grade mucinous carcinomas and benign cystadenomas.